A5072871975- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Axon Guidance and Neuronal Signaling
- Nerve injury and regeneration
- Cellular Mechanics and Interactions
- Hereditary Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Microbial infections and disease research
- RNA Research and Splicing
- Graph theory and applications
- Cellular transport and secretion
- Invertebrate Immune Response Mechanisms
- Connexins and lens biology
- Developmental Biology and Gene Regulation
- Wnt/β-catenin signaling in development and cancer
- Escherichia coli research studies
- Retinal Development and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Graph Labeling and Dimension Problems
- Microtubule and mitosis dynamics
- Advanced Graph Theory Research
- Hearing, Cochlea, Tinnitus, Genetics
- Barrier Structure and Function Studies
- Skin and Cellular Biology Research
- Microbial bioremediation and biosurfactants
The University of Texas Health Science Center at San Antonio
2014-2025
National Institute of Mental Health and Neurosciences
2025
Government Medical College
2017-2024
Veterinary & Animal Husbandry
2004-2024
University of Kashmir
2021-2023
Government Medical College
2023
Punjabi University
2023
The University of Texas Health Science Center at Tyler
2020
Urology San Antonio
2020
Annamalai University
2019
The mechanistic target of rapamycin (mTOR) signaling pathway plays a major role in key cellular processes including metabolism and differentiation; however, the mTOR microglia its importance Alzheimer9s disease (AD) have remained largely uncharacterized. We report that selective loss <i>Tsc1</i>, negative regulator mTOR, mice both sexes, caused activation upregulation Trem2 with enhanced β-Amyloid (Aβ) clearance, reduced spine loss, improved cognitive function <i>5XFAD</i> AD mouse model....
The evolutionary demand for rapid nerve impulse conduction led to the process of myelination-dependent organization axons into distinct molecular domains. These domains include node Ranvier flanked by highly specialized paranodal where myelin loops and axolemma orchestrate axoglial septate junctions. junctions are formed interactions between a glial isoform neurofascin (Nfasc(NF155)) axonal Caspr Cont. Here we report generation myelinating glia-specific Nfasc(NF155) null mouse mutants. mice...
Surprisingly little is known about the impact of entrapment neuropathy on target innervation and relationship nerve fibre pathology to sensory symptoms signs. Carpal tunnel syndrome most common neuropathy; aim this study was investigate its effect morphology small unmyelinated as well myelinated axons relate such changes somatosensory function clinical symptoms. Thirty patients with a electrophysiological diagnosis carpal [17 females, mean age (standard deviation) 56.4 (15.3)] 26 gender...
The node of Ranvier is a distinct domain myelinated axons that highly enriched in sodium channels and critical for impulse propagation. During development, the channel subtypes expressed at undergo transition from Na<sub>v</sub>1.2 to Na<sub>v</sub>1.6. Specialized junctions form between paranodal glial membranes axon flank nodes are candidates regulate their maturation delineate boundaries. To investigate these roles, we characterized development mice deficient contactin-associated protein...
Septate junctions (SJs) in epithelial and neuronal cells play an important role the formation maintenance of charge size selective barriers. They form basis for ensheathment nerve fibers Drosophila attachment myelin loops to axonal surface vertebrates. The cell-adhesion molecules NRX IV/Caspr/Paranodin (NCP1), contactin Neurofascin-155 (NF-155) are all present at vertebrate axo-glial SJs. Mutational analyses have shown that NCP1 its homolog, Neurexin IV (NRX IV) required In this study, we...
Abstract The Drosophila embryonic peripheral nervous system (PNS) is an excellent model to study the molecular mechanisms governing neural development. To identify genes controlling PNS development, we screened 2000 lethal P-element insertion strains. of mutant embryos was examined using specific marker MAb 22C10, and 92 strains were retained for further analysis. Genetic cytological analysis these shows that 42 mutations affect previously isolated are known be required development:...
Axonal insulation is critical for efficient action potential propagation and normal functioning of the nervous system. In Drosophila , underlying basis nerve ensheathment axonal by glial cells establishment septate junctions (SJs) between cell membranes. However, details cellular molecular mechanisms SJ formation are still obscure. Here, we report characterization in peripheral system (PNS). Targeted expression tau-green fluorescent protein ultrastructural analysis nerves allowed us to...
Pseudomonas cepacia CSV90 is able to utilize 2,4-dichlorophenoxyacetate (2,4-D) and 2-methyl-4-chlorophenoxyacetate as sole sources of carbon energy. Mutants the strain which had lost this ability appeared spontaneously on a nonselective medium. The wild-type harbored 90-kb plasmid, pMAB1, whereas 2,4-D-negative mutants either plasmid or 70-kb pMAB2. pMAB2 was found have undergone deletion 20-kb fragment pMAB1. plasmid-free regained degrade 2,4-D after introduction purified pMAB1 by...
Epithelial tubes are the functional units of many organs, but little is known about how tube sizes established. Using Drosophila tracheal system as a model, we previously showed that mutations in varicose (vari) cause to become elongated without increasing cell number. Here show vari required for accumulation size-control proteins Vermiform and Serpentine lumen. We also an essential septate junction (SJ) gene encoding membrane associated guanylate kinase (MAGUK). In vivo analyses domains...
Axo–glial junctions (AGJs) play a critical role in the organization and maintenance of molecular domains myelinated axons. Neurexin IV/Caspr1/paranodin (NCP1) is an important player formation AGJs because it recruits paranodal complex implicated tethering glial proteins to axonal membrane cytoskeleton. Mice deficient either protein NCP1 or ceramide galactosyltransferase (CGT) display disruptions severe ataxia. In this article, we correlate these two phenotypes show that both CGT mutants...
Adherens and tight junctions play key roles in assembling epithelia maintaining barriers. In cell culture zonula occludens (ZO)–family proteins are important for assembly/maturation of both adherens (AJs). Genetic studies suggest that ZO during normal development, but interpretation mouse fly is limited by genetic redundancy and/or a lack null alleles. We generated alleles the single Drosophila protein Polychaetoid (Pyd). Most embryos lacking Pyd die with striking defects morphogenesis...
Usher syndrome is the leading cause of genetic deaf–blindness. Monoallelic mutations in PDZD7 increase severity type II caused by USH2A and GPR98 , which respectively encode usherin GPR98. PDZ domain-containing 7 protein (PDZD7) a paralog scaffolding proteins harmonin whirlin, are implicated 1 2 syndromes. While have been reported to form hair cell stereocilia ankle-links, localizes upper tip-link density whirlin both tip ankle-link regions. Here, we used mass spectrometry show that...