A5052437674- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Geotechnical Engineering and Soil Stabilization
- Pancreatic function and diabetes
- Plant Pathogens and Fungal Diseases
- Medical Research and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Geotechnical Engineering and Underground Structures
- Web Data Mining and Analysis
- Cancer Immunotherapy and Biomarkers
- Mycorrhizal Fungi and Plant Interactions
- Mass Spectrometry Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Geotechnical Engineering and Analysis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renin-Angiotensin System Studies
- Peptidase Inhibition and Analysis
- Graph Theory and Algorithms
- Particle physics theoretical and experimental studies
- China's Ethnic Minorities and Relations
- Myxozoan Parasites in Aquatic Species
Chengdu Medical College
2018-2025
Fudan University
2020-2024
Hebei University of Science and Technology
2023-2024
China Agricultural University
2024
Beijing Jiaotong University
2023
Northwestern University
2023
Guangzhou Vocational College of Science and Technology
2021
Guangzhou Sport University
2021
Bangkokthonburi University
2021
Thonburi University
2021
Rosmarinic acid (α-o-caffeoyl-3,4-dihydroxyphenyllactic acid, RA) is a major active constituent of Rosmarinus officinalis Linn. (rosemary) having significant anti-inflammatory, anti-apoptotic, and antioxidant effects. However, the cardioprotection RA still not understood. The present study was designed, for first time, to investigate on myocardial infarction (MI)-induced cardiac fibrosis clarify possible mechanisms. MI induced in adult rats by left anterior descending coronary artery...
Interactions between plants and their endophytes alter metabolic functions ability to cope with abiotic stresses. In this study, high-throughput sequencing was used analyze the species diversity of in Cyperus esculentus var. sativus (CES) tubers under different heavy metal stress conditions. The results indicated that number observed endophytic increased (p < 0.05), leading changes composition. response tuber concentrations varied, certain bacteria fungi, such as Pseudomonas,...
Indoleamine 2,3-dioxygenase (IDO) is involved in tumor immune escape and resistance to chemotherapy, clinically correlated with progression. IDO inhibitors show marginal efficacy as single agents; therefore, combinations of these other therapies hold promise for cancer therapy. The aim this study was investigate the synergistic antitumor effects inhibitor NLG919 combination different regimens paclitaxel a murine B16-F10 melanoma model. increased cytotoxic activity toward cells presence...
Significance The mechanism of functional changes induced by alternative splicing GHRHR is largely unknown. Here, we demonstrate that GHRH-elicited signal bias toward β-arrestin recruitment constitutively mediated SV1. cryogenic electron microscopy structures SV1 and molecular dynamics simulations reveal the different functionalities between at near-atomic level (i.e., N termini differentiate downstream signaling pathways, G s versus β-arrestins). Our findings provide valuable insights into...
The glucagon-like peptide-1 receptor (GLP-1R) is a well-established drug target for the treatment of type II diabetes. development small-molecule positive allosteric modulators (PAMs) GLP-1R promising therapeutic strategy. Here, we report discovery and characterization PAMs with distinct chemotypes, binding to cryptic pocket formed by cytoplasmic half TM3, TM5, TM6. Molecular dynamic simulations mutagenesis studies indicate that PAM enlarges orthosteric facilitate GLP-1 binding. Further...
Abstract The purpose of this study was to characterize a novel compound, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl) ethyl] phenyl 3-nitrophenyl ether, designated LPM580153. We used several well-validated animal models depression assess the antidepressant-like activity LPM580153, followed by neurotransmitter uptake assay and corticosterone-induced cell injury model explore its mechanism action. In mice, LPM580153 reduced immobility time in tail suspension test, rats subjected chronic...
Based on the engineering practice of first prefabricated subway station (Shuangfeng Station) in Changchun, China, applicability structures (PSSSs) liquefiable sites seismically defended areas is investigated. In this paper, finite difference software FLAC3D 5.0 used to carry out seismic response analysis PSSS ground, and calculation results are compared with those same type cast-in-place condition. The show that trend foundation excess pore pressure ratio (EPPR) condition similar For...
Mahvash disease, a rare autosomal recessive metabolic disorder characterized by biallelic loss-of-function mutations in the glucagon receptor gene (
Glucagon is a peptide hormone secreted by islet α cells. It plays crucial roles in glucose homeostasis and metabolism activating its cognate glucagon receptor (GCGR). A naturally occurring deleterious mutation V368M the human GCGR leads to reduced ligand binding down-regulation of signaling. To examine association between this metabolic disorders, knock-in mouse model bearing homozygous V369M substitution (equivalent V368M) was made using CRISPR-Cas9 technology. These GcgrV369M+/+ mice...
We previously demonstrated that receptor for activated C kinase 1 (RACK1) inhibited phosphorylated extracellular signal-regulated (p-ERK) during morphine reward in mice. In the present study, we examined role of Src regulating inhibition p-ERK brain following RACK1 over-expression reward.Mice were subcutaneously injected with on days 2, 4, 6, and 8 after pre-test (day 1), saline was delivered day. After mice showed place preference, plasmid administered by intraventricular injection 20...
Objective: The objective of this article is to study the role dopamine (DA) D1 receptor in midbrain periaqueductal grey (PAG) on learning and memory morphine-addicted rats.Methods: DA agonist SKF81297 antagonist SCH SCH23390 were administrated into PAG, respectively, behavioral changes morphine addicted rats detected by water maze. Western blot immunohistochemistry used detect glutamate decarboxylase 67 (GAD67) tyrosine kinase B (TrkB) PAG.Results: shortened latency platform increased number...
Adenoviral vectors are superior to plasmid in their gene transport efficiency. The A subunit of the diphtheria toxin (DTA) is a popular suicide cancer therapy. However, DTA seldom used adenoviral therapy due its great toxicity. toxicity so that even single molecule enough kill one cell. To avoid this highly toxic effect on normal cells, should be controlled by tumor-specific promoters. survivin promoter widely promoter. But genes driven show low level basal expression non-cancer cells. may...
Abstract Thioredoxin‐interacting protein (TXNIP) overexpression is implicated in the pathogenesis of type 2 diabetes. Previous studies have shown that a small molecule compound (W2476) was able to improve β‐cell dysfunction and exert therapeutic effects diabetic mice via repression TXNIP signaling pathway. The impact W2476 on transcription thus investigated using chromatin immunoprecipitation method. It found promotes competitive binding forkhead box O1 factor (FOXO1) carbohydrate response...
In the present study, complete mitochondrial genome of Trichosporon inkin was sequenced and assembled. The T. contained 22 protein-coding genes (PCG), 2 ribosomal RNA (rRNA) genes, 24 transfer (tRNA) genes. total size is 39,466 bp, with GC content 27.56%. Phylogenetic analysis based on combined gene dataset indicated that exhibited a close relationship asahii.
To represent the textual knowledge more expressively, a kind of semantic-based graph structure is proposed for this issue and thereafter applied to clustering problems. Such representation consists nodes directed edges, which stand feature terms derived from texts semantic relationships between them, respectively. Moreover, weight assigned each edge so that strength relationship two can be measured. For weighted structure, novel similarity algorithm developed by extracting maximum common...
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