A5088459093- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
- Macrophage Migration Inhibitory Factor
- Phagocytosis and Immune Regulation
- Radiopharmaceutical Chemistry and Applications
- Magnolia and Illicium research
- Cell Adhesion Molecules Research
- Phytochemical compounds biological activities
- Plant Toxicity and Pharmacological Properties
- Synthesis and Biological Evaluation
- Phytochemistry and Biological Activities
- Peptidase Inhibition and Analysis
- Botanical Research and Chemistry
- Flood Risk Assessment and Management
- Bioactive Compounds and Antitumor Agents
- Immune cells in cancer
- Microbial Natural Products and Biosynthesis
- Landslides and related hazards
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Epigenetics and DNA Methylation
- Hydrology and Watershed Management Studies
Fudan University
2020-2024
Hohai University
2021
East China University of Science and Technology
2015-2016
Second Military Medical University
2016
The recently approved KRAS
Although tyrosine kinase inhibitor therapy and immunotherapy have significantly improved lung cancer management, many patients do not benefit or become resistant to treatment, highlighting the need for novel treatments. We found elevated CD73 expression be prevalent in non-small cell (NSCLC) including those harboring RAS- RTK (EGFR, EML4-ALK) oncogenes. is enriched closely with transcriptome signature of epithelial-mesenchymal transition immune-tolerant tumor microenvironment, which are...
Two new quinone enantiomers (−) and (+)-merrilliaquinone (<bold>1a</bold>, <bold>1b</bold>) were isolated from <italic>Illicium merrillianum</italic>, <bold>1b</bold> exhibited a selective cytotoxicity between human hepatoma cell lines normal hepatic cells, while <bold>1a</bold> didn't have such activity.
We constructed a small library of indole terpenoid mimics using hybridizing strategy to link various and α,β-unsaturated enone building blocks together. Prepared compounds were evaluated for the cytotoxicity against panel cancer cell lines. An indolyl ketone called JP18 was identified as cycle regulator, underlying mechanism investigated.
Abstract Review: 46 refs.
Abstract Merrilliaquinone, a new racemic quinone has been isolated from Illicium merrillianum, chiral separated, and spectroscopic analyzed.
<p>Supplementary Figures and Tables</p>
<p>Supplementary Figures and Tables</p>
<div>Abstract<p>Although tyrosine kinase inhibitor therapy and immunotherapy have significantly improved lung cancer management, many patients do not benefit or become resistant to treatment, highlighting the need for novel treatments. We found elevated CD73 expression be prevalent in non–small cell (NSCLC) including those harboring RAS- RTK (EGFR, EML4-ALK) oncogenes. is enriched closely with transcriptome signature of epithelial–mesenchymal transition immune-tolerant tumor...
<div>Abstract<p>Although tyrosine kinase inhibitor therapy and immunotherapy have significantly improved lung cancer management, many patients do not benefit or become resistant to treatment, highlighting the need for novel treatments. We found elevated CD73 expression be prevalent in non–small cell (NSCLC) including those harboring RAS- RTK (EGFR, EML4-ALK) oncogenes. is enriched closely with transcriptome signature of epithelial–mesenchymal transition immune-tolerant tumor...