A5022284915- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Medicinal Plants and Neuroprotection
- Workplace Health and Well-being
- Employment and Welfare Studies
- Telomeres, Telomerase, and Senescence
- Inflammatory Biomarkers in Disease Prognosis
- Emotional Labor in Professions
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Regulation of Appetite and Obesity
- Functional Brain Connectivity Studies
Capital Medical University
2022-2024
Ministry of Education of the People's Republic of China
2024
Xuan Wu Hospital of the Capital Medical University
2024
Chinese Academy of Sciences
2024
Peking University
2024
Capital University
2024
Fujian Medical University
2023
Fujian Provincial People's Hospital
2023
Fujian Provincial Hospital
2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2022-2023
Despite significant advances in neuroscience, the mechanisms of AD are not fully understood. Single-cell RNA sequencing (scRNA-seq) techniques provide potential solutions to analyze cellular composition complex brain tissue and explore molecular biological AD.We investigated heterogeneity via utilization bioinformatic analysis scRNA-seq patients healthy controls from Gene Expression Omnibus (GEO) database. The "GOplot" package was applied possible processes oligodendrocytes, astrocytes,...
In China, many patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. Several studies have shown that triple therapy [transarterial chemoembolization (TACE) combined tyrosine kinase inhibitors (TKIs) and immune checkpoint (ICIs)] is beneficial for patient survival. this study, we aimed to evaluate the efficacy of (TACE + TKIs ICIs) unresectable HCC (uHCC) conversion rate surgical resection (SR). The primary endpoints were objective response (ORR) disease control...
BACKGROUND: The correlation between the preoperative albuminalkaline phosphatase ratio (AAPR) and prognosis of hepatocellular carcinoma (HCC) patients after radical resection is still not comprehensive. OBJECTIVE: This study aims to observe AAPR HCC resection. METHODS: We constructed a retrospective cohort included 656 who underwent were grouped determining an optimum cut-off value. used Cox proportional regression model assess RESULTS: optimal value for assessing was 0.52 which acquired by...
Abstract Background It is challenging to predict which patients who meet criteria for subcor‐ tical ischemic vascular disease (SIVD) will ultimately progress subcortical cognitive impairment (SVCI). Method We collected clinical information, neuropsychological assessments, T1 imag‐ ing, diffusion tensor imaging, and resting‐state functional magnetic resonance imaging from 83 with SVCI 53 age‐matched SIVD without cogni‐ tive impairment. built an unsupervised machine learning model isolate...
Mutations in the embryonic ectoderm development (EED) cause Weaver syndrome, but whether and how EED affects brain remains elusive. Here, we generated a mouse model which Eed was deleted forebrain to investigate role of EED. We found that deletion decreased number upper-layer neurons not deeper-layer starting at E16.5. Transcriptomic genomic occupancy analyses revealed epigenetic states group cortical neurogenesis-related genes were altered knockout forebrains, followed by decrease H3K27me3...
Shift work nurses suffered great stress and emotion dysregulation during the COVID-19 pandemic. Interpersonal regulation has emerged as a promising therapeutic approach, often facilitated through confiding. It been suggested that medical staff benefit from confiding, with act of reflecting on social support gained confiding being associated higher well-being. Consequently, we hypothesized thinking about derived work-related hassles could enhance well-being in shift nurses. This study aimed...
ABSTRACT Aims The nucleus basalis of Meynert (NBM) is a major source cholinergic innervation in the central nervous system. We aimed to investigate characteristics structural and functional alterations NBM its projections patients with mild cognitive impairment (MCI) effects computerized training (CCT). Methods Forty‐five MCI 45 cognitively unimpaired controls (CUCs) were recruited. volume, mean diffusivity (MD) white matter (WM) projections, connectivity (FC) measured T1‐weighted imaging,...
Abstract Background Blood biomarkers provide a non‐invasive and accessible means of detection for Alzheimer's disease (AD). Specifically, associated with early‐onset AD (EOAD) illuminate the underlying mechanisms valuable guidance potential therapies. We aim to present blood biomarker evidence in individuals both EOAD late‐onset (LOAD), as well age‐matched healthy controls. Methods A total 95 participants were enrolled study. assessed levels 18 distinct biomarkers, concurrently examined...
Abstract Blood-brain barrier (BBB) impairment, which causes leakage of harmful peripheral substances into the brain, is an early indicator Alzheimer’s disease (AD). Microglia are known to regulate BBB integrity, but underlying mechanisms this process remain unclear. We here analyzed permeability and structural integrity in mice. Loss TREM2 function was found impair BBB; TREM2-deficient microglia showed CCL2 upregulation via activation NFκB pathway. The CCL2-CCR2 axis reduced expression...
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia worldwide. Dysregulation various metabolism pathways may mediate development AD pathology cognitive dysfunction. Variants triggering receptor expressed on myeloid cells‐2 (TREM2) are known to increase risk developing AD. TREM2 plays role in by maintaining cellular energy biosynthesis, but precise mechanism through which it accomplishes this unknown. Method In present...
Abstract Background It is challenging to distinguish which subcortical ischemic vascular disease (SIVD) patients will present with cognitive impairment. A blood‐based biomarker SIVD impairment would be superior neuropsychological measures and neuroimaging in terms of cost, time, feasibility for repeated measures. Metabolomics profiling studies could help identify biomarkers Method 100 without impairment,70 impairment, 30 DLB AD were recruited from three Chinese research hospitals. 34...