A5004089318- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Dyeing and Modifying Textile Fibers
- Dementia and Cognitive Impairment Research
- Cerebrospinal fluid and hydrocephalus
- Skin Protection and Aging
- Nanoparticles: synthesis and applications
- Advanced Glycation End Products research
- Clostridium difficile and Clostridium perfringens research
- Phytochemistry and Bioactivity Studies
- melanin and skin pigmentation
- Hydrogels: synthesis, properties, applications
- Genetics, Aging, and Longevity in Model Organisms
- Pluripotent Stem Cells Research
- Effects and risks of endocrine disrupting chemicals
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Neuroscience of respiration and sleep
- Saffron Plant Research Studies
- Fetal and Pediatric Neurological Disorders
- Collagen: Extraction and Characterization
- Gold and Silver Nanoparticles Synthesis and Applications
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2022-2025
Beike Biotechnology (China)
2025
Xiamen University
2011
Despite significant advances in neuroscience, the mechanisms of AD are not fully understood. Single-cell RNA sequencing (scRNA-seq) techniques provide potential solutions to analyze cellular composition complex brain tissue and explore molecular biological AD.We investigated heterogeneity via utilization bioinformatic analysis scRNA-seq patients healthy controls from Gene Expression Omnibus (GEO) database. The "GOplot" package was applied possible processes oligodendrocytes, astrocytes,...
The eye is closely connected to the brain, providing a unique window detect pathological changes in brain. In this study, we discovered β-amyloid (Aβ) deposits along ocular glymphatic system patients with Alzheimer’s disease (AD) and 5×FAD transgenic mouse model. Interestingly, Aβ from brain can flow into eyes optic nerve through cerebrospinal fluid (CSF), causing retinal degeneration. mainly observed sheath, neural axon, perivascular space, which might represent critical steps of...
Background Increasing evidence supports the role of microRNAs (miRNAs) in major depressive disorder (MDD), but pathophysiological mechanism remains elusive. Aims To explore microRNA-451a (miR-451a) pathology and behaviours depression. Methods Abnormal miRNAs such as miR-451a reported previously serum patients with MDD were screened then confirmed a mouse model depression induced by chronic restraint stress (CRS). Eight-week-old male C57BL/6 mice had overexpression medial prefrontal cortex...
Amphiphilic polysaccharides can be used as wall materials and applied to encapsulate hydrophobic active chemicals; moreover, there is significant demand for novel medical high-molecular-weight with various functions. In order prepare amphiphilic schizophyllan (SPG), octenyl succinic anhydride (OSA) was chosen synthesize OSA-modified (OSSPG) using an esterified reaction. The modification of OSSPG demonstrated through FT-IR thermal analysis. Moreover, it found that has a better capacity...
Background: Alzheimer's disease (AD) patients are often accompanied by depressive symptoms, but its underlying mechanism remains unclear.The present study aimed to explore the potential role of microRNAs in comorbidity AD and depression.Methods: The miRNAs associated with depression were screened from databases literature then confirmed cerebrospinal fluid (CSF) different ages transgenic APP/PS1 mice.AAV9-miR-451a-GFP was injected into medial prefrontal cortex (mPFC) mice at seven months,...
Elastin is a crucial component of the extracellular matrix that plays significant role in maintaining skin elasticity and firmness. Within dermis, elastin works collaboration with collagen to form supportive structures contribute overall health appearance skin. As individuals age, rate synthesis gradually declines, resulting degradation elastic fibers, which subsequently leads laxity formation wrinkles. Furthermore, environmental factors, particularly ultraviolet radiation, can exacerbate...
Early diagnosis and accurate prognosis of cognitive decline in Alzheimer's disease (AD) is important to timely assignment optimal treatment modes. We aimed develop a deep learning model predict conversion guide re-assignment decisions more intensive therapies where needed. Longitudinal data including five variable sets, i.e. demographics, medical history, neuropsychological outcomes, laboratory neuroimaging results, from the Disease Neuroimaging Initiative (ADNI) cohort were analyzed. first...
ABSTRACT Background A growing body of evidence suggests a link between the gut microbiota and Alzheimer's disease (AD), although underlying mechanisms remain elusive. This study aimed to investigate impact fecal transplantation (FMT) on cognitive function in mouse model AD. Methods Four‐month‐old 5 × FAD (familial disease) mice underwent antibiotic treatment deplete their native microbiota. Subsequently, they received FMT either weekly or every other day. After 8 weeks, β‐amyloid (Aβ) load...
Schizophyllum commune ( S. ) fermented supernatant with added Radix Puerariae (SC-RP) showed significant antioxidant activity in our previous work. However, the possible lifespan and healthspan extending capacity of Caenorhabditis elegans C. underlying mechanism were not illuminated. In this study, effect SC-RP on improving stress resistance examined. Additionally, molecular mechanisms explored. Treated at 10 μg/mL, increased by 24.89% P < 0.01). Also, prolonged nematode, including...
Abstract Animal behavioral tests are often conducted during the day. However, rodents nocturnal animals and primarily active at night. The aim of this study was to determine whether there diurnal changes in cognitive anxiety‐like performance mice following chronic sleep restriction (SR). We also investigated phenotypic difference is related variation glymphatic clearance metabolic wastes. Mice received 9‐day SR by use modified rotating rod method, followed open field, elevated plus maze,...
The polyphenols extraction of Phyllanthus emblica is primarily carried out using organic solvents, and assisted by physical fields such as ultrasound microwave for extraction. High voltage pulsed electric field technology (PEF) a non-thermal processing that has high efficiency minimal damage to thermosensitive substances. PEF been applied plant in many studies, however, the from still not reported; This study explores optimal process PEF, investigates its relaxation anti-wrinkle based on...
Genome-wide association studies identified variants around the BIN1 (bridging integrator 1) gene locus as prominent risk factors for late-onset Alzheimer disease. In present study, we decreased expression of in mouse hippocampal neurons to investigate its neuronal function. Bin1 knockdown via RNAi reduced dendritic arbor size primary cultured well mature Cornu Ammonis 1 excitatory neurons. The AAV-mediated also generated a significant regional volume loss injection sites at organ level,...
Abstract Mitochondrial dysfunction is a well‐established hallmark of Alzheimer's disease (AD). Despite recent documentation transcellular mitochondrial transfer, its role in the pathogenesis AD remains unclear. In this study, we report an impairment quality within astrocytes and neurons adult 5 × FAD mice. Following treatment with mitochondria isolated from aged induced by exposure to amyloid protein or extended cultivation, cultured exhibited excessive generation reactive oxygen species...
A design scheme of remote model predictive control system is presented in this paper. Combined with the asynchronous messaging framework Errai, a network application for control, which based on GWT architecture, developed and implemented by using RIA technique. The field MPC product extended function expanded effectively system, can assist monitoring production process, provide approach multi-line communication, emergency response, data mining consulting service. Therefore it guarantee...
Preparation of green ionic liquid using natural alkaloids and organic acids for efficient transdermal delivery GHK-Cu.
Cognitive decline is the most dominant and patient-oriented symptom during development of Alzheimer's disease (AD) mild cognitive impairment (MCI). This study was designed to test feasibility hybrid convolutional neural networks long-short-term memory (CNN-LSTM) modeling driven early decision-tailoring with predicted long-term conversion in AD MCI. Characteristics patients or MCI covering demographic features, clinical time-dependent neuropsychological-related features were fused into...
A PEF-DES technique was used to extract flavonoids from Kapok with a TG-KF yield of 14.36 ± 0.35%; in vitro and vivo data show that has good stability, safety antioxidative activity, suggesting potential as natural anti-aging material health cosmetics.