A5101757837- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- PARP inhibition in cancer therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Folate and B Vitamins Research
- Connexins and lens biology
- EEG and Brain-Computer Interfaces
- Hormonal Regulation and Hypertension
- Immune cells in cancer
- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- Microtubule and mitosis dynamics
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Glutathione Transferases and Polymorphisms
- Wnt/β-catenin signaling in development and cancer
- Medicinal Plants and Neuroprotection
- Phagocytosis and Immune Regulation
- Telomeres, Telomerase, and Senescence
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2015-2024
Suzhou University of Science and Technology
2022
Nanjing Maternity and Child Health Care Hospital
2021
Shandong First Medical University
2020
Shandong Provincial Hospital
2020
China Medical University
2018
Tianjin Medical University Cancer Institute and Hospital
2015
Wenzhou Medical University
2014
Abstract Background Acquired chemoresistance is a major challenge in the clinical treatment of glioblastoma (GBM). Circular RNAs have been verified to play role tumor chemoresistance. However, underlying mechanisms remain unclear. The aim this study was elucidate potential and molecular mechanism circular (circ)RNA ADP-ribosylation factor GTPase activating proteins with Src homology 3 domain, ankyrin repeat Pleckstrin domain 1 (circASAP1) temozolomide (TMZ) resistance GBM. Methods We...
Programmed cell death is an important biological process that plays indispensable role in traumatic brain injury (TBI). Inhibition of necroptosis, a type programmed death, pivotal neuroprotection and preventing associated inflammatory responses. Our results showed necroptosis occurred human tissues after TBI. Necroptosis was also induced by controlled cortical impact (CCI) rat model TBI accompanied high translocation high-mobility group box-1 (HMGB1) to the cytoplasm. HMGB1 then passed...
See Happold and Weller (doi:10.1093/awv301) for a scientific commentary on this article. Resistance to temozolomide poses major clinical challenge in glioblastoma multiforme treatment, the mechanisms underlying development of resistance remain poorly understood. Enhanced DNA repair mutagenesis can allow tumour cells survive, contributing recurrence. Here, using recurrent temozolomide-refractory specimens, temozolomide-resistant cells, resistant-xenograft models, we report that loss miR-29c...
Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to damaged and alter an individual's susceptibility cancer. We studied whether polymorphisms are associated with increased risk glioma development. genotyped 10 potentially functional single nucleotide (SNPs) 7 pathway (XRCC3, BRCA2, RAG1, XRCC5, LIG4, XRCC4 ATM) case–control study including 384 patients cancer-free controls Chinese Han population. Genotypes were determined using OpenArray...
Abstract The acquisition of drug resistance is a persistent clinical problem limiting the successful treatment human cancers, including glioblastoma (GBM). However, molecular mechanisms by which initially chemoresponsive tumors develop therapeutic remain poorly understood. In this study, we report that Pol κ, an error-prone polymerase participates in translesion DNA synthesis, was significantly upregulated GBM cell lines and tumor tissues following temozolomide treatment. Overexpression κ...
Astrocytes are more resistant to ischemia and hypoxia in the acute phase of brain injury after traumatic (TBI). Previous study showed that gap junction alpha 1 (GJA1) phosphorylation can increase survival damaged astrocytes. The GJA1-20 k expression neurons co-culture with astrocytes was positively correlated exosomes uptake. This aims explore effect exogenous carried by astrocyte-derived on apoptosis mitochondrial function TBI. were co-cultured neuron with/without damage from air pressure....
Polarized macrophages can be broadly classified into classically activated (M1) and alternatively (M2) in response to the microenvironment signals. Interferon regulatory factor 1 (IRF1) has been demonstrated play a critical role macrophage polarization. However, mechanisms underlying regulation of IRF1 expression polarization still remain unclear. In this study, was significantly increased interferon-γ (IFN-γ) lipopolysaccharide (LPS)-treated RAW264.7 cells. Moreover, miR-130b-3p decreased...
Vascular inflammation and endothelial dysfunction secondary to unchecked activation of endothelium are key mechanisms underlying sepsis organ failure. However, the intrinsic processes that mitigate excessive cell remain incompletely understood. To determine central role adenosine A2a receptor (A2aR) on macrophages in modulating lipopolysaccharide (LPS)-induced vascular dysfunction, we constructed macrophage A2aR-conditional knockout (Mac-A2aR KO) mice, stimulated mice with LPS. A2aR agonist,...
This comprehensive study evaluates the performance of OpenAI's o1-preview large language model across a diverse array complex reasoning tasks, spanning multiple domains, including computer science, mathematics, natural sciences, medicine, linguistics, and social sciences. Through rigorous testing, demonstrated remarkable capabilities, often achieving human-level or superior in areas ranging from coding challenges to scientific processing creative problem-solving. Key findings include: -83.3%...
The oxidative stress mechanism is of particular interest in the pathogenesis glioma, given high rate oxygen metabolism brain. Potential links between polymorphisms antioxidant genes and glioma risk are currently unknown. We therefore investigated association risk. examined 16 single nucleotide (SNPs) 9 (GPX1, CAT, PON1, NQO1, SOD2/MnSOD, SOD3, NOS1*2*3) 384 control cases a Chinese hospital-based case–control study. Genotypes were determined using OpenArray platform, which employs chip-based...
Traumatic brain injury (TBI) is a devastating actuality in clinics worldwide. It estimated that approximately 10 million people among the world suffer from TBI each year, and considerable number of patients will be temporarily or permanently disabled even die due to this disease. Astrocytes play very important role repair tissue after TBI, including formation neuroprotective barrier, inhibition edema, normal nerve cell apoptosis. However, detailed mechanism underlying protective effect still...
Abstract Poly ADP‐ribose polymerase inhibitors (PARPi) have shown promising therapeutic efficacy in triple‐negative breast cancer (TNBC) patients. However, resistance ultimately develops, preventing a curative effect from being attained. Extensive investigations indicated the diversity mechanisms underlying PARPi sensitivity of cancer. In this study, we found that DNA damage binding protein 2 (DDB2), damage‐recognition factor, could protect TNBC cells by regulating double‐strand break repair...
Maturation of postnatal β-cells is regulated in a cell-autonomous manner, and metabolically stressed regress to an immature state, ensuring defective β-cell function the onset type 2 diabetes. The molecular mechanisms connecting nutritional transition maturation remain largely unknown. Here, we report mature form miRNA (miR-203)/ZBTB20/MAFA regulatory axis that mediates process. We show level (miR-203) changes during miR-203 inhibits at neonatal stage under high-fat diet conditions. Using...
Genome-wide association studies identified variants around the BIN1 (bridging integrator 1) gene locus as prominent risk factors for late-onset Alzheimer disease. In present study, we decreased expression of in mouse hippocampal neurons to investigate its neuronal function. Bin1 knockdown via RNAi reduced dendritic arbor size primary cultured well mature Cornu Ammonis 1 excitatory neurons. The AAV-mediated also generated a significant regional volume loss injection sites at organ level,...