A5063542096- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Advanced battery technologies research
- Ferroptosis and cancer prognosis
- Hedgehog Signaling Pathway Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrocatalysts for Energy Conversion
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Trace Elements in Health
- TGF-β signaling in diseases
- Curcumin's Biomedical Applications
- Metabolomics and Mass Spectrometry Studies
- Advanced Battery Materials and Technologies
- Neonatal and fetal brain pathology
- Cancer, Lipids, and Metabolism
- Supercapacitor Materials and Fabrication
- Cell Adhesion Molecules Research
- Stress Responses and Cortisol
- Heat shock proteins research
- Glioma Diagnosis and Treatment
Nanjing Medical University
2019-2024
Jiangsu Province Hospital
2019-2024
Changzhou University
2024
Prokineticin-2 (Prok2) is an important secreted protein likely involved in the pathogenesis of several acute and chronic neurological diseases through currently unidentified regulatory mechanisms. The initial mechanical injury neurons by traumatic brain triggers multiple secondary responses including various cell death programs. One these ferroptosis, which associated with dysregulation iron thiols culminates fatal lipid peroxidation. Here, we explore role Prok2 neuronal ferroptosis vitro...
Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by the iron-dependent lipid reactive oxygen species (ROS) accumulation, but its mechanism in gliomas remains elusive. Acyl-coenzyme A (CoA) synthetase long-chain family member 4 (Acsl4), pivotal enzyme regulation biosynthesis, benefits initiation ferroptosis, role needs further clarification. Erastin, classic inducer has recently been found to regulate peroxidation regulating Acsl4 other than glutathione...
Abstract Background The microglia-mediated inflammatory response is a vital mechanism of secondary damage following traumatic brain injury (TBI), but the underlying microglial activation unclear. Methods Controlled cortical impact (CCI) was induced in adult male C57BL/6J mice, and glutamate used to construct classical vitro model primary microglia. Microglial determined by western blot immunostaining. factors were measured enzyme-linked immunosorbent assay. oxidative stress marker...
Abstract Glioblastoma (GBM) is the most universal type of primary brain malignant tumour, and prognosis patients with GBM poor. S100A11 plays an essential role in tumour. However, molecular mechanism are not clear. Here, we found that was up‐regulated tissues higher expression indicated poor patients. Overexpression promoted cell growth, epithelial‐mesenchymal transition (EMT), migration, invasion generation glioma stem cells (GSCs), whereas its knockdown inhibited these activities. More...
Glioblastoma (GBM) is one of the most aggressive and lethal cancer types in humans. The standard treatment approach surgery followed by chemoradiation. However, molecular mechanisms innate tumor radioresistance remain poorly understood.We tested expression Smoothened (Smo) primary recurrent GBM tissues cells. Then, we determined radiation effectiveness against Lastly, functional role Smo was further confirmed vitro vivo experiments.We reported that significantly upregulated cell lines...
Abstract Microglial cells are key component of central nervous system (CNS) and mediate the immune response brain under physiological or pathological conditions. It tends to activate into a pro‐inflammatory M1 phenotype after traumatic injury (TBI) promote secondary damage. Recently, necroptosis was found microglial activation neuroinflammation TBI. However, mechanism specific interventions TBI remain poorly investigated. Here, we reported that overexpress charged multivesicular body protein...
Traumatic brain injury (TBI), which is characterized by acute neurological dysfunction, also one of the most widely recognized environmental risk factors for various and psychiatric disorders. However, role TBI in perturbation mechanisms underlying these disorders remain unknown. We evaluated transcriptional changes cells frontal cortex after exploiting single-cell RNA sequencing (scRNA-Seq). adopted gene expression omnibus scRNA-Seq to identify mediation secretogranin II (SCG2) TBI-induced...
Aqueous zinc batteries are considered as one of the most promising energy storage systems for large-scale and wearable electronics, owing to their low cost intrinsic safety. However, cathode materials that can reversibly host Zn<sup>2+</sup> still less. Here, we demonstrate two N-containing organic compounds, hexamethoxy hexaazatrinaphthylene (HMHATN) (HATN), used cathodes exhibit excellent reversible capability with fast kinetics high capacity 542 963 mA h...
Aqueous zinc batteries are considered as one of the most promising energy storage systems for large-scale and wearable electronics, owing to their low cost intrinsic safety. However, cathode materials that can reversibly host Zn 2+ still less. Here, we demonstrate two N-containing organic compounds, hexamethoxy hexaazatrinaphthylene (HMHATN) (HATN), used cathodes exhibit excellent reversible capability with fast kinetics high capacity 542 963 mA h g -1 , respectively. The Zn//HMHATN Zn//HATN...
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