A5034745688- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Autophagy in Disease and Therapy
- Quantum Computing Algorithms and Architecture
- Cloud Computing and Resource Management
- Signaling Pathways in Disease
- Hedgehog Signaling Pathway Studies
- Circular RNAs in diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Quantum Information and Cryptography
- Advancements in Semiconductor Devices and Circuit Design
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Sleep and Wakefulness Research
- Curcumin's Biomedical Applications
- Cell Adhesion Molecules Research
- Medicinal Plant Pharmacodynamics Research
- Hippo pathway signaling and YAP/TAZ
- GDF15 and Related Biomarkers
- Ferroptosis and cancer prognosis
- Trace Elements in Health
Nanjing Medical University
2019-2024
Jiangsu Province Hospital
2019-2024
Kyushu University
2023
Anhui University of Traditional Chinese Medicine
2021
Shandong Provincial QianFoShan Hospital
2017
Shandong University
2017
Wuhan University
2013
Renmin Hospital of Wuhan University
2013
Prokineticin-2 (Prok2) is an important secreted protein likely involved in the pathogenesis of several acute and chronic neurological diseases through currently unidentified regulatory mechanisms. The initial mechanical injury neurons by traumatic brain triggers multiple secondary responses including various cell death programs. One these ferroptosis, which associated with dysregulation iron thiols culminates fatal lipid peroxidation. Here, we explore role Prok2 neuronal ferroptosis vitro...
Abstract Background The microglia-mediated inflammatory response is a vital mechanism of secondary damage following traumatic brain injury (TBI), but the underlying microglial activation unclear. Methods Controlled cortical impact (CCI) was induced in adult male C57BL/6J mice, and glutamate used to construct classical vitro model primary microglia. Microglial determined by western blot immunostaining. factors were measured enzyme-linked immunosorbent assay. oxidative stress marker...
The oncogene Aurora kinase A (AURKA) has been implicated in various tumor, yet its role meningioma remains unexplored. Recent studies have suggested a potential link between AURKA and ferroptosis, although the underlying mechanisms are unclear. This study presented evidence of upregulation high grade ability to enhance malignant characteristics. We identified as suppressor erastin-induced ferroptosis meningioma. Mechanistically, directly interacted with phosphorylated kelch-like...
Regulation of the oxidative stress response is crucial for management and prognosis traumatic brain injury (TBI). The copper chaperone Antioxidant 1 (Atox1) plays a role in regulating intracellular ion balance impacting antioxidant capacity mitochondria, as well state cells. However, it remains unknown whether Atox1 involved modulating following TBI. Here, we investigated regulatory on neurons both vivo vitro, elucidated underlying mechanism through culturing hippocampal HT-22 cells with...
Abstract Glioblastoma (GBM) is the most universal type of primary brain malignant tumour, and prognosis patients with GBM poor. S100A11 plays an essential role in tumour. However, molecular mechanism are not clear. Here, we found that was up‐regulated tissues higher expression indicated poor patients. Overexpression promoted cell growth, epithelial‐mesenchymal transition (EMT), migration, invasion generation glioma stem cells (GSCs), whereas its knockdown inhibited these activities. More...
Glioblastoma (GBM) is one of the most aggressive and lethal cancer types in humans. The standard treatment approach surgery followed by chemoradiation. However, molecular mechanisms innate tumor radioresistance remain poorly understood.We tested expression Smoothened (Smo) primary recurrent GBM tissues cells. Then, we determined radiation effectiveness against Lastly, functional role Smo was further confirmed vitro vivo experiments.We reported that significantly upregulated cell lines...
Abstract Tumour invasion is closely related to the prognosis and recurrence of glioblastoma multiforme partially attributes epithelial‐mesenchymal transition. Long intergenic non‐coding RNA 00511 (LINC00511) plays a pivotal role in tumour; however, LINC00511 GBM, especially epigenetic molecular regulation mechanism EMT, still unclear. Here, we found that was up‐regulated GBM tissues relatively high expression predicted poorer prognosis. Moreover, ectopic enhanced cells proliferation,...
Abstract Microglial cells are key component of central nervous system (CNS) and mediate the immune response brain under physiological or pathological conditions. It tends to activate into a pro‐inflammatory M1 phenotype after traumatic injury (TBI) promote secondary damage. Recently, necroptosis was found microglial activation neuroinflammation TBI. However, mechanism specific interventions TBI remain poorly investigated. Here, we reported that overexpress charged multivesicular body protein...
Quantum computing has emerged as a promising domain for the machine learning (ML) area, offering significant computational advantages over classical counterparts. With growing interest in quantum (QML), ensuring correctness and robustness of software platforms to develop such QML programs is critical. A necessary step reliability understand bugs they typically suffer from. To address this need, paper presents first comprehensive study frameworks. We inspect 391 real-world collected from 22...
Firstly, hydrotalcite (HT) was synthesized by the urea method. Then, sodium methyl allyl sulfonate (SMAS) used as intercalation agent to prepare intercalated HT (SMAS–HT). Finally, a novel poly(acrylic-co-acrylamide)/HT nanocomposite superabsorbent prepared inverse suspension polymerization, using N,N′-methylenebisacrylamide (NMBA) cross-linking and potassium persulfate (KPS) an initiator. The morphology of superabsorbents characterized FT-IR, XRD, SEM TEM. influences amount SMAS–HT on water...
DNN models across many domains continue to grow in size, resulting high resource requirements for effective training, and unpalatable (and often unaffordable) costs organizations research labs scales. This paper aims significantly reduce training with use of preemptible instances, i.e., those that can be obtained at a much cheaper price while idle, but may preempted whenever requested by priority users. Doing so, however, requires new forms resiliency efficiency cope the possibility frequent...
Static analysis is the process of analyzing software code without executing software. It can help find bugs and potential problems in that may only appear at runtime. Although many static tools have been developed for classical software, due to nature quantum programs, these existing are unsuitable programs. This paper presents QChecker, a tool supports finding programs Qiskit. QChecker consists two main modules: module extracting program information based on abstract syntax tree (AST),...
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