A5101459229- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Mosquito-borne diseases and control
- Intracerebral and Subarachnoid Hemorrhage Research
- Nausea and vomiting management
- Anesthesia and Pain Management
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Brain Injury Research
- Cancer Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Gut microbiota and health
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metabolism and Genetic Disorders
- Neurological diseases and metabolism
- Galectins and Cancer Biology
- Blood Coagulation and Thrombosis Mechanisms
- Spinal Cord Injury Research
Guangdong Pharmaceutical University
2025
Affiliated Hospital of North Sichuan Medical College
2024
Jiangsu Province Hospital
2015-2024
Nanjing Medical University
2015-2024
People’s University
2022
XinHua Hospital
2021
Wuxi No.2 People's Hospital
2016-2021
Lions Gate Hospital
2019
First Hospital of Jilin University
2011
Jilin University
2011
Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the underlying mechanisms remain poorly understood. Dysfunctional mitochondria, main source reactive oxygen species, are impacted in inflammation activation. This study aimed to examine effect melatonin on via elimination damaged mitochondria after controlled cortical impact, an vivo model traumatic brain injury (TBI). Here, we demonstrated that inhibition mitophagy, selective degradation by autophagy, markedly...
Mitochondrial energy production is essential for normal brain function. Traumatic injury (TBI) increases demands, results in the activation of mitochondrial respiration, associated with enhanced generation reactive oxygen species. This chain events triggers neuronal apoptosis via oxidation a mitochondria-specific phospholipid, cardiolipin (CL). One pathway through which cells can avoid elimination damaged mitochondria by mitophagy. Previously, we showed that externalization CL to surface...
Abstract Primary subarachnoid hemorrhage (SAH) is a type of acute stroke, accounting for approximately 10% cases, with high disability and mortality rate. Early brain injury (EBI) critical factor in determining SAH mortality; however, there are no effective treatment interventions EBI. Based on our results, the transmission cyclic GMP-AMP (cGAMP) from neurons to microglia key molecular event that triggers I interferon response, amplifies neuroinflammation, leads neuronal apoptosis. Abnormal...
Gastrointestinal dysfunction is one of several physiologic complications in patients with traumatic brain injury (TBI). TBI can result increased intestinal permeability resulting from apoptosis epithelial cells, which contain a large number mitochondria for persisting barrier function. Autophagy damaged (mitophagy) controls the quality and regulates cellular homeostasis. However, exact mechanism mitophagy that underlies pathological changes induced by unknown. Here, we report decreases cell...
Gut dysbiosis is associated with chronic kidney disease (CKD), and serum free immunoglobulin light chains (FLCs) are biomarkers for CKD. This study aims to assess the CKD gut microbiome determine its impact on FLC levels.To control confounders, 100 patients sex- age-matched healthy controls (HCs) were recruited. The was assessed by sequencing 16S rRNA gene V3-V4 hypervariable regions. Phylogenetic Investigation of Communities Reconstruction Unobserved States applied infer functional...
CBX7, a member of the Polycomb-group proteins, plays significant role in normal and cancerous tissues has been defined as tumor suppressor thyroid, breast pancreatic cancers. However, its function glioma remains undefined. CBX7 expression is decreased glioma, especially higher grade cases, according to data CGGA, GSE16001 TCGA databases. Further experimental evidence shown that exogenous overexpression induced apoptosis inhibited cell proliferation, colony formation migration cells. In this...
Thyroid hormone (TH) plays a crucial role in neurodevelopment, but its function and specific mechanisms remain unclear after traumatic brain injury (TBI). Here we found that treatment with triiodothyronine (T3) ameliorated the progression of neurological deficits mice subjected to TBI. The data showed T3 reduced neural death promoted elimination damaged mitochondria via mitophagy. However, did not prevent TBI-induced cell phosphatase tensin homolog (PTEN)-induced putative kinase 1 (Pink1)...
Recent studies have shown that dexmedetomidine can be safely used in peripheral nerve blocks and spinal anesthesia. Epidural administration of produces analgesia sedation, prolongs motor sensory block time, extends postoperative analgesia, reduces the need for rescue analgesia. This investigation seeks to identify median effective concentration (EC
Traumatic brain injury (TBI), which is characterized by acute neurological dysfunction, also one of the most widely recognized environmental risk factors for various and psychiatric disorders. However, role TBI in perturbation mechanisms underlying these disorders remain unknown. We evaluated transcriptional changes cells frontal cortex after exploiting single-cell RNA sequencing (scRNA-Seq). adopted gene expression omnibus scRNA-Seq to identify mediation secretogranin II (SCG2) TBI-induced...
Patients often suffer moderate or even severe pain after total hip arthroplasty; such seriously affects early postoperative recovery. This study aimed to investigate the analgesic efficacy of ultrasound-guided transmuscular quadratus lumborum block combined with fascia iliaca compartment for elderly patients undergoing arthroplasty.Fifty-four scheduled arthroplasty were included in this randomized controlled study. The randomly assigned receive only (group Q) QF) ultrasound guidance....
Abstract Background Although the neurotransmitter dopamine (DA) plays a crucial pathophysiologic role after traumatic brain injury (TBI), its function and specific underlying mechanisms of action remain unclear. Methods Adult male mice underwent controlled cortical impact (CCI). We administered DA intraperitoneally to for 14 consecutive days, starting 8 h before CCI. On day 3 injury, lesion volume water content were measured. days 7–13, behavioral tests performed. Results Herein we report...
Potential predictive biomarker(s) to respond chemotherapy in gastric cancer are unclear. Excision repair cross-complementing 1 (ERCC1), a DNA enzyme, is associated with clinical outcomes cancer. Here, we investigated the expression of ERCC1 platinum-based after surgery, and association between parameters was analyzed. Our data showed that high levels were positively resistance but not lymph node metastasis pathological stage. In addition, patients probably had
Expert groups have recommended incorporation of a geriatric assessment into clinical practice for older patients starting oncologic therapy. However, that is not standard primarily because resource limitations. In the present study, we evaluated effect on treatment decisions by oncologists in community oncology setting brief tool estimates risk toxicity.This prospective longitudinal study 5 practices British Columbia involved 70 years age and new cytotoxic chemotherapy regimen. Clinical...