A5045906060- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Nanofabrication and Lithography Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Advancements in Photolithography Techniques
- Periodontal Regeneration and Treatments
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Advanced Surface Polishing Techniques
- Pelvic and Acetabular Injuries
- Autophagy in Disease and Therapy
- Radiopharmaceutical Chemistry and Applications
- Hippo pathway signaling and YAP/TAZ
- Total Knee Arthroplasty Outcomes
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Bone fractures and treatments
- Force Microscopy Techniques and Applications
Nanjing Medical University
2013-2024
Jiangsu Province Hospital
2011-2024
Peking University
2023
Peking University Third Hospital
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2022
Chongqing Medical University
2021-2022
Sichuan University
2022
West China Hospital of Sichuan University
2022
Wuhan National Laboratory for Optoelectronics
2012-2014
Huazhong University of Science and Technology
2012-2014
Mitochondrial energy production is essential for normal brain function. Traumatic injury (TBI) increases demands, results in the activation of mitochondrial respiration, associated with enhanced generation reactive oxygen species. This chain events triggers neuronal apoptosis via oxidation a mitochondria-specific phospholipid, cardiolipin (CL). One pathway through which cells can avoid elimination damaged mitochondria by mitophagy. Previously, we showed that externalization CL to surface...
Abstract Background Osteoarthritis (OA) is a common degenerative disease involving articular cartilage, in which ferroptosis of chondrocytes plays an important role. Baicalin (BAI) exerts regulatory effects wide range orthopedic diseases including OA, but its effect on (CHs) still unclear. The purpose this study was to determine the BAI human OA (OACs), and explore possible mechanism. Methods CHs were treated with IL-1β (10 ng/mL) simulate inflammation vitro. Immunofluorescence, quantitative...
A fiber optic current sensor based on a polarization-rotated reflected interferometer has been constructed. special spun highly birefringent is designed and achieved for the by heating spinning commercial linearly fiber. In contrast with conventional fibers, integrates function of quarter wave plate. Particularly, fabricating working principle head using are expounded. The achieves an accuracy 0.5% good linearity shown in temperature dependence (a drift 0.008%/ <formula formulatype="inline"...
Osteoarthritis (OA) is an age-related joint disease that characterised by the degeneration of articular chondrocytes. Ginsenosides, most important pharmacological ingredients ginseng, have been proven to provide effective therapy for neurodegenerative diseases and can inhibit cell apoptosis. We investigated whether ginsenoside Rb1 modulate inflammation apoptosis in human chondrocytes.Chondrocytes were isolated from OA patients undergoing total knee replacement surgery. Apoptosis was assessed...
Recently, three-dimensional (3D) bioprinting technology is becoming an appealing approach for osteochondral repair. However, it challenging to develop a bilayered scaffold with anisotropic structural properties mimic native tissue. Herein, we developed bioink consisting of decellularized extracellular matrix and silk fibroin print the scaffold. The mimics natural tissue by controlling composition, mechanical properties, growth factor release in each layer vitro results show that scaffolds...
Osteosarcoma (OS) is the most prevalent primary bone malignancy affecting adolescents, yet emergence of chemoradiotherapeutic resistance has limited efforts to cure affected patients date. Pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPa-PDT) a recently developed, minimally invasive treatment for OS that similarly constrained by such therapeutic resistance. This study sought explore mechanistic basis RhoA-activated YAP1 (YAP)-mediated in OS.The relationship between YAP...
Repair of articular cartilage defects using bilayered scaffolds is problematic because tissue-engineered prone to overgrowth toward subchondral bone, resulting in structural abnormalities and bone. A "twice freeze-drying" technique was used construct a dense isolation layer between the bone layers an integrated scaffold prevent from excessive downgrowth. Briefly, beta-tricalcium phosphate for scaffold, high-concentration chitosan/gelatin solution layer, low-concentration layer. As controls,...
Abstract Osteosarcoma (OS) is the primary malignant bone tumor with a peak incidence in children and adolescents. However, little molecular mechanism of pathogenesis has been known it urgent to develop new therapeutical strategies improve outcomes for patients. CDDO‐NFM (N‐formylmorpholine substituent CDDO) newly synthesized triterpenoid, which derivative oleanolic acid. In this study, we explored whether possesses potential antitumor effect revealed its mechanism. We found that efficiently...
In the present study, effects and mechanisms of mesenchymal stem cells (MSCs) on interleukin (IL)-1β‑stimulated rat chondrocytes, as well cartilage from a model osteoarthritis (OA) induced by anterior cruciate ligament transection medial meniscectomy were investigated. Confluent chondrocytes treated with IL-1β (10 ng/ml), then cultured indirectly or without MSCs at ratio 2:1. Total RNA protein collected various time-points, western blot reverse transcription-quantitative polymerase chain...
Objective To explore the clinical efficacy of intramedullary reduction techniques for irreducible intertrochanteric femoral fractures with negative medial cortical support. Methods A retrospective analysis was conducted on 69 patients support treated in Department Orthopedics at Jiangsu Province Hospital (The First Affiliated Nanjing Medical University) from July 2019 to December 2021. Patients were divided into Group and B. (experimental group) consisted 36 cases an average age 76.2 ± 5.9...
The aim of the present study is to investigate clinical value Ilizarov transverse tibial bone transport and microcirculation reconstruction in treatment chronic ischemic diseases lower limbs. A total 90 patients with limbs were selected randomly divided into two groups: observation group (n=45) control (n=45). Those treated reconstruction, percutaneous balloon angioplasty (PTBA), respectively. Changes diameter, blood flow limb arteries paretic side, wound healing time, disappearance time...
The application of multilayered monolithic scaffolds to repair osteochondral defects has become a hot research topic due the advantage simulating native physiological structure. However, it was difficult promote proliferation and migration different kinds cells in corresponding layers under same culture condition. Besides, methods utilized previous researches construct tissue-engineered were time-consuming, laborious, complicated, costly ensure quality integration construction. Inspired by...
The potential empty spaces between cylindrical plugs remaining after autologous osteochondral mosaicplasty rely on fibrous repair, which may constrain the quality and integrity of repair. Thus, should be repaired, how to fill is still a problem. In present study, standardized full-thickness defect (diameter, 6 mm) was created in weight-bearing area each medial femoral condyle both knees 18 miniature pigs. 36 were randomly assigned four groups with nine group. defects initially repaired by...
Soft mold imprinting has been widely used to improve quality and uniformity in large area nano-imprint processes because of its flexibility. However, the aspect ratio soft is limited physical properties. In this paper, a multi-mask layers transfer process was demonstrated realize high imprint process. process, thin hard mask as an intermediate for layer fabrication. Based on this, 60 nm line width gratings mask, whose higher than 4, fabricated; we also realized uniform photonic crystal (PC)...
Photodynamic therapy (PDT), which is a new method for treating tumors, has been used in the treatment of cancer. In-depth research shown that PDT cannot completely kill tumor cells, indicating cells are resistant to PDT. Glucose regulatory protein 78 (GRP78), key regulator endoplasmic reticulum stress, confirmed be related resistance and recurrence, but there relatively few studies on further mechanism GRP78 Our experiment aimed observe role HOS human osteosarcoma treated with...
The osteoarthritis caused by trauma or inflammation is associated with severe patient morbidity and economic burden. Accumulating studies are focusing on the repair of articular cartilage defects constructing tissue-engineered cartilage. Recent evidence suggests that optimizing source quality seed cells one key points tissue engineering. In this study, we demonstrated Kindlin-2 its activated PI3K/AKT signaling played an essential role in promoting extracellular matrix (ECM) secretion...
Osteochondral defects involving cartilage and subchondral bone are difficult to repair. Recently, scientists have attempted develop composite scaffolds for repair of osteochondral injuries. However, the available do not fully recapitulate functions cartilage, bone, cancellous bone. In this study, we developed a bioactive multiphase scaffold by decellularizing an intact graft The porosity mechanical properties were optimized using laser drilling collagen digestion. promoted recellularization...