A5100777211- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Traumatic Brain Injury Research
- Cancer-related Molecular Pathways
- Trauma and Emergency Care Studies
- Cancer-related molecular mechanisms research
- Obstructive Sleep Apnea Research
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Neuroscience of respiration and sleep
- Trauma Management and Diagnosis
- Inflammasome and immune disorders
- Intracranial Aneurysms: Treatment and Complications
- Vascular Anomalies and Treatments
- Dietary Effects on Health
- Radiomics and Machine Learning in Medical Imaging
- Lipoproteins and Cardiovascular Health
- Caveolin-1 and cellular processes
- Computational Drug Discovery Methods
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Research and Splicing
Second Military Medical University
2013-2024
Shanghai Changzheng Hospital
2024
Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the underlying mechanisms remain poorly understood. Dysfunctional mitochondria, main source reactive oxygen species, are impacted in inflammation activation. This study aimed to examine effect melatonin on via elimination damaged mitochondria after controlled cortical impact, an vivo model traumatic brain injury (TBI). Here, we demonstrated that inhibition mitophagy, selective degradation by autophagy, markedly...
Abstract The median survival time of lower grade glioma (LGG) tumors spans a wide range 2–10 years and is highly dependent on the molecular characteristics tumor location. Currently, there no prognostic predictor for these based autophagy‐related (ATG) genes. A risk score model most significant seven ATG genes was established LGG. These genes, including GRID2, FOXO1, MYC, PTK6, IKBKE, BIRC5, TP73, have been screened as potentially therapeutic targets. Kaplan–Meier curve analyses validated...
It is widely accepted that traumatic brain injury (TBI) increases the risk of developing long-term dementia, although some controversies surrounding this topic exist. Annually, approximately 69 million individuals suffer from TBI all around world. Such a large population patients could lead to future surge in number dementia patients. Due potentially severe consequences TBI, various research projects on post-TBI have emerged worldwide. Therefore, it essential comprehend current status and...
Background Despite advances in neuro-oncology, treatments of glioma and tools for predicting the outcome patients remain limited. The objective this research is to construct a prognostic model using Homologous Recombination Deficiency (HRD) score validate its predictive capability glioma. Methods We consolidated datasets from TCGA, various cancer types pan-cancer HRD analysis, two additional RNAseq GEO CGGA databases. scores, mutation data, other genomic indices were calculated. Using...
Objective To evaluate the animal model of traumatic skull base artery injury (TSBAI) established by high-pressure intraarterial injection method. Methods Fifty New Zealand rabbits were submitted to carotid (experiment group, n=20), tension-free (sham n=20) and simple exposure (control n=10), according random number table. Animal survival was observed. Diameters measured using CT angiography (CTA). Pathological changes involved monitored under microscope. Results There three...