A5101995015- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Extracellular vesicles in disease
- Connexins and lens biology
- Mesenchymal stem cell research
- Neurological Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- S100 Proteins and Annexins
- Tissue Engineering and Regenerative Medicine
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pluripotent Stem Cells Research
- Angiogenesis and VEGF in Cancer
- Sulfur Compounds in Biology
- Cardiac Fibrosis and Remodeling
- Pharmacological Effects of Medicinal Plants
- Mitochondrial Function and Pathology
- Congenital heart defects research
- Obstructive Sleep Apnea Research
- Renal and related cancers
- Neuroscience of respiration and sleep
Soochow University
2015-2025
First Affiliated Hospital of Soochow University
2015-2025
Nanchang University
2008-2021
First Affiliated Hospital of Nanchang University
2011-2021
Morehouse School of Medicine
2019
Shanghai Sixth People's Hospital
2012
Astrocytes are more resistant to ischemia and hypoxia in the acute phase of brain injury after traumatic (TBI). Previous study showed that gap junction alpha 1 (GJA1) phosphorylation can increase survival damaged astrocytes. The GJA1-20 k expression neurons co-culture with astrocytes was positively correlated exosomes uptake. This aims explore effect exogenous carried by astrocyte-derived on apoptosis mitochondrial function TBI. were co-cultured neuron with/without damage from air pressure....
Induced vascular progenitor cells (iVPCs) were created as an ideal cell type for regenerative medicine and have been reported to positively promote collateral blood flow improve cardiac function in a rat model of myocardial ischemia. Exosomes emerged novel biomedicine that mimics the donor cells. We investigated angiogenic activity exosomes from iPVCs (iVPC-Exo) cell-free therapeutic approach iVPCs aortic endothelial (RAECs) isolated using combination ultrafiltration size-exclusion...
Angiogenesis takes place after brain ischaemia, and stroke-induced angiogenesis in ischaemic may be associated with improved neurological recovery. Bone MSCs (marrow stromal cells) transplantation can promote this vital zones, but the mechanisms by which promoting are unclear. The Notch signalling pathway play an important role embryonic blood vessels development tumour angiogenesis, whether it is also involved cerebral ischaemia uncertain. We therefore investigated stroke. Rats were...
Traumatic brain injury (TBI) is a devastating actuality in clinics worldwide. It estimated that approximately 10 million people among the world suffer from TBI each year, and considerable number of patients will be temporarily or permanently disabled even die due to this disease. Astrocytes play very important role repair tissue after TBI, including formation neuroprotective barrier, inhibition edema, normal nerve cell apoptosis. However, detailed mechanism underlying protective effect still...
The gap junction is important in the propagation of dilation/constriction signals along vessels for coordinated behavior control vascular tone. authors hypothesized that junctions might play a role cerebral vasospasm following subarachnoid hemorrhage (SAH). aims present study were to investigate and observe potential therapeutic efficacy blockers vitro vivo.For investigation, effect heptanol on oxyhemoglobin (HbO(2))-induced contraction isolated rabbit basilar arteries (BAs) was observed by...