A5101966011- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Genomics and Phylogenetic Studies
- Probiotics and Fermented Foods
- Advanced Memory and Neural Computing
- Polysaccharides and Plant Cell Walls
- Cancer-related molecular mechanisms research
- Plant Pathogens and Fungal Diseases
- Circular RNAs in diseases
- TGF-β signaling in diseases
- Cancer therapeutics and mechanisms
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Immunotherapy and Immune Responses
- EFL/ESL Teaching and Learning
- Nicotinic Acetylcholine Receptors Study
- Neural Networks Stability and Synchronization
- Cardiac electrophysiology and arrhythmias
- Seaweed-derived Bioactive Compounds
- Lung Cancer Treatments and Mutations
- Peroxisome Proliferator-Activated Receptors
- Epilepsy research and treatment
- Ion Channels and Receptors
National University of Singapore
2021-2025
Guangdong Pharmaceutical University
2024-2025
Shanghai Institute of Applied Physics
2025
Chinese Academy of Sciences
2022-2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Institute of Botany
2022-2024
University of Chinese Academy of Sciences
2022-2024
Shandong University of Traditional Chinese Medicine
2024
Burning Rock Biotech (China)
2024
Sinopec (China)
2024
Abstract GCaMP, one popular type of genetically-encoded Ca 2+ indicator, has been associated with various side-effects. Here we unveil the intrinsic problem prevailing over different versions and applications, showing that GCaMP containing CaM (calmodulin) interferes both gating signaling L-type calcium channels (Ca V 1). acts as an impaired apoCaM /CaM, critical to 1, which disrupts dynamics gene expression. We then design implement GCaMP-X, by incorporating extra apoCaM-binding motif,...
Abstract PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels), is involved in sour sensation and other pH-dependent processes. PKD2L1 believed to be a nonselective cation channel that can regulated by voltage, protons, calcium. Despite its considerable importance, molecular mechanisms underlying regulations are largely unknown. Here, we determine atomic structure at 3.38 Å resolution cryo-electron microscopy, whereby side chains of nearly all residues assigned. Unlike...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive type of interstitial pneumonia with unknown causes, poor prognosis and no effective therapy available. Circular RNAs (circRNAs), which serve as potential therapeutic targets diagnostic biomarkers for certain diseases, represent recent hotspot in the field RNA research. In present study, total 67 significantly dysregulated circRNAs were identified plasma IPF patients by using circRNA microarray. Among these circRNAs, 38...
Abstract Understanding how dietary polysaccharides affect mucin O -glycosylation and gut microbiota could provide various nutrition-based treatments. Here, the -glycan profile of colonic mucosa microbiome were investigated in C57BL/6J mice fed six structurally diverse a mixture fibers. Dietary increased total -glycans, mainly by stimulating neutral glycans. Highly branched arabinogalactan promoted terminally fucosylated core 1 -glycans; whereas linear polysaccharides, including pectin,...
Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain or discomfort. Previous studies have illustrated that the gut microbiota might play critical role in IBS, but conclusions of these studies, based on various methods, were almost impossible to compare, and reproducible microorganism signatures still question. To cope with this problem, previously published 16S rRNA gene sequencing data from 439 fecal samples, including 253 IBS samples 186...
Background Hypoxia is associated with the evasion of triple-negative breast cancer (TNBC) from immune surveillance. increases subpopulation putative TNBC stem-like cells (TNBCSCs) through activating Wnt/β-Catenin signaling. The shedding MHC class I-related chain A (MICA) particularly noteworthy in stem (CSCs), promoting resistance CSCs to natural killer (NK) cell cytotoxicity. To reestablish MICA/NKG2D-mediated immunosurveillance, we proposed design a fusion protein (SHH002-hu1-MICA) which...
Cancer recurrence after surgical resection remains a grand challenge in achieving long-term eradication. Here, we develop biocompatible and implantable immunostimulant microneedle patch designed to suppress local tumor surgery. The patch, fabricated using methacrylate-modified hyaluronic acid, incorporates 2'3'-cGAMP, STING agonist, IL-2, cytokine approved for clinical cancer immunotherapy that expands T cells. enables controlled release of cGAMP induce dendritic cell maturation, antitumor...
Abstract Gleditsia sinensis is an endemic species widely distributed in China with high economic and medicinal value. To explore the genomic evolution phylogenetic relationships of G. , complete mitochondrial (mt) genome was sequenced assembled, which firstly reported . The mt circular 594,121 bp length, including 37 protein-coding genes (PCGs), 19 transfer RNA (tRNA) 3 ribosomal (rRNA) genes. overall base composition 27.4% for A, T, 22.6% G, 22.7% C. comparative analysis PCGs Fabaceae...
ConspectusFunctional and structural studies of ion channels have deepened our understanding their mechanisms important role in regulating neuronal activity treating disease. Manipulation can directly control electrochemical signals the nervous cardiovascular systems for advanced neuromodulation theranostics. tools based on channel control, such as optogenetics, electrical stimulation, chemogenetics, gene editing, basic biomedical research enabled unprecedented treatment strategies....
Head rice yield (HRY) is an essential quality trait, and sensitive to environmental stresses during the grain-filling, harvest, postharvest stages. It therefore important for production global food security select superior HRY traits; however, molecular basis of this trait remains unknown. Using diverse germplasm material, we performed a genome-wide association study grain fissure resistance (GFR), phenotype most associated with HRY, found that granule-bound starch synthase I gene Waxy...
Background: DNA sensors are innate immune receptors that detect intracellular endogenous or exogenous DNA. They critical to trigger response against viral and bacterial infection, involved in inflammatory diseases tumorigenesis. Recent accumulating evidences indicated also crucial for controlling the development of colorectal cancer (CRC). However, a systematic study on expression profile CRC their clinical significance still lacking. Methods: We investigated by taking advantage samples,...