A5058621057- Genetic and Kidney Cyst Diseases
- Calcium signaling and nucleotide metabolism
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Neurotransmitter Receptor Influence on Behavior
- Escherichia coli research studies
- Neuroscience and Neuropharmacology Research
- Antibiotic Resistance in Bacteria
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Receptor Mechanisms and Signaling
- Salmonella and Campylobacter epidemiology
- Pharmacogenetics and Drug Metabolism
- Ion Transport and Channel Regulation
Tsinghua University
2013-2018
Center for Life Sciences
2018
University of Pittsburgh
2013-2015
A complex implicated in kidney health Autosomal dominant polycystic disease (ADPKD) is a common genetic that can lead to failure. Mutations the proteins PKD1 and PKD2 are linked disease, but function of these remains unclear, both physiology disease. has been sensing chemical mechanical force stimuli, proposed be calcium ion channel. Su et al. show transmembrane regions form PKD1-PKD2 assembled 1:3 ratio. Their high-resolution cryo–electron microscopy structure confirms adopts transient...
Quantitative analysis of known drug–target interactions emerged in recent years as a useful approach for drug repurposing and assessing side effects. In the present study, we method that uses probabilistic matrix factorization (PMF) this purpose, which is particularly analyzing large interaction networks. DrugBank drugs clustered based on PMF latent variables show phenotypic similarity even absence 3D shape similarity. Benchmarking computations outperforms those recently introduced provided...
Human dopamine (DA) transporter (hDAT) regulates dopaminergic signaling in the central nervous system by maintaining synaptic concentration of DA at physiological levels, upon reuptake into presynaptic terminals. translocation involves co-transport two sodium ions and channeling a chloride ion, it is achieved via alternating access between outward-facing (OF) inward-facing states DAT. hDAT target for addictive drugs, such as cocaine, amphetamine (AMPH), therapeutic antidepressants. Our...
Abstract PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels), is involved in sour sensation and other pH-dependent processes. PKD2L1 believed to be a nonselective cation channel that can regulated by voltage, protons, calcium. Despite its considerable importance, molecular mechanisms underlying regulations are largely unknown. Here, we determine atomic structure at 3.38 Å resolution cryo-electron microscopy, whereby side chains of nearly all residues assigned. Unlike...
NleC is one of the virulence factors that injected into infected host cells by enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC EHEC) via a needle-like protein complex called type III secretion system (T3SS). The cytosolic specifically cleaves p65 subunit NF-κB in p65–p50 heterodimeric just after Cys38 site its N-terminal domain. degradation remainder C-terminal domain proteasome disrupts NF-κB signalling pathway, thus dampening inflammatory response. Here, crystal structure...