A5050247940- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Genetic and Kidney Cyst Diseases
- Bacterial Genetics and Biotechnology
- Renal and related cancers
- Gout, Hyperuricemia, Uric Acid
- Muscle Physiology and Disorders
- Immune Cell Function and Interaction
- Genetic Syndromes and Imprinting
- Listeria monocytogenes in Food Safety
- Adipose Tissue and Metabolism
- Biochemical and Molecular Research
- Alcohol Consumption and Health Effects
- Calcium signaling and nucleotide metabolism
- Enzyme Production and Characterization
- Cellular Mechanics and Interactions
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Ion Transport and Channel Regulation
City University of Macau
2025
Tsinghua University
2018-2024
Center for Life Sciences
2018-2024
A complex implicated in kidney health Autosomal dominant polycystic disease (ADPKD) is a common genetic that can lead to failure. Mutations the proteins PKD1 and PKD2 are linked disease, but function of these remains unclear, both physiology disease. has been sensing chemical mechanical force stimuli, proposed be calcium ion channel. Su et al. show transmembrane regions form PKD1-PKD2 assembled 1:3 ratio. Their high-resolution cryo–electron microscopy structure confirms adopts transient...
Abstract Bacteriophage infection, a pivotal process in microbiology, initiates with the phage’s tail recognizing and binding to bacterial cell surface, which then mediates injection of viral DNA. Although comprehensive studies on interaction between bacteriophage lambda its outer membrane receptor, LamB, have provided rich information about system’s biochemical properties, precise molecular mechanism remains undetermined. This study revealed high-resolution cryo-electron microscopy (cryo-EM)...
Abstract Urate, the physiological form of uric acid and a potent antioxidant in serum, plays pivotal role scavenging reactive oxygen species. Yet excessive accumulation urate, known as hyperuricemia, is primary risk factor for development gout. The high-capacity urate transporter GLUT9 represents promising target gout treatment. Here, we present cryo-electron microscopy structures human complex with or its inhibitor apigenin at overall resolutions 3.5 Å 3.3 Å, respectively. In both...
Abstract PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels), is involved in sour sensation and other pH-dependent processes. PKD2L1 believed to be a nonselective cation channel that can regulated by voltage, protons, calcium. Despite its considerable importance, molecular mechanisms underlying regulations are largely unknown. Here, we determine atomic structure at 3.38 Å resolution cryo-electron microscopy, whereby side chains of nearly all residues assigned. Unlike...
F-type phage tail-like bacteriocins (PTLBs) are high-molecular-weight protein complexes exhibiting bactericidal activity and share evolutionary similarities with the tails of non-contractile siphoviruses. In this study, we present atomic structure monocin, a genetically engineered PTLB from Listeria monocytogenes. Our detailed atomic-level analysis, excluding two chaperone proteins, provides crucial insights into molecular architecture PTLBs. The core monocin resembles TP901-1-like tails,...