A5032552452- Lung Cancer Diagnosis and Treatment
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Lung Cancer Treatments and Mutations
- Pain Mechanisms and Treatments
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Spondyloarthritis Studies and Treatments
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Advanced Materials and Mechanics
- Barrier Structure and Function Studies
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dengue and Mosquito Control Research
- Anesthesia and Sedative Agents
- Pharmacological Effects of Natural Compounds
- Hedgehog Signaling Pathway Studies
- Hydrogen's biological and therapeutic effects
Jiangnan University
2022-2025
Tianjin Medical University
2025
Tianjin Medical University Eye Hospital
2025
Zhoushan Hospital
2015-2024
First Affiliated Hospital of Zhengzhou University
2015-2024
Shenyang Pharmaceutical University
2024
Jiangsu Cancer Hospital
2019-2024
Nanjing Medical University
2019-2024
First Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
Diabetic wounds are blocked in the inflammatory stage, growth factors degraded, and blood vessels difficult to regenerate, leading continuous necrosis nonhealing of wound. Hydrogen sulfide (H2S) plays an important role pathophysiological process wound healing has a long history treating skin diseases. Although salt solution is preferred donor exogenous H2S, its rapid release rate, excess production, difficulty accurately controlling dose limit use. Herein, we developed H2S sustained-release...
Sonic Hedgehog (Shh) plays an essential role in vertebrate organogenesis as well the development of some cancers, including breast cancer. The aim present study was to characterize more precisely its carcinogenesis and elucidate regulation mechanisms. expression Shh investigated 97 carcinomas 22 paired non‐tumorous tissues (distant from primary tumor) by immunohistochemistry four cell lines Western blotting. We also analyzed methylation status gene with methylation‐specific PCR assessed...
Recently, paclitaxel (PTX) was reported to increase intracellular lipid reactive oxygen species (ROS) levels, triggering cancer cell ferroptosis. Based on this, some efforts had been made improve PTX treatment for non-small-cell lung (NSCLC). Our previous studies demonstrated that triptolide (TPL) could the antitumor effect of PTX. Nevertheless, poor solubility and side effects often limit application chemotherapy drugs. In this paper, we constructed a novel nanodrug delivery system (NDDS)...
The objectives of this study were to determine the effect tumor necrosis factor alpha (TNF-alpha) on intestinal epithelial cell permeability and expression tight junction proteins. Caco-2 cells plated onto Transwell microporous filters treated with TNF-alpha (10 or 100 ng/mL) for 0, 4, 8, 16, 24 h. transepithelial electrical resistance mucosal-to-serosal flux rates established paracellular marker Lucifer yellow measured in filter-grown monolayers cells. localization protein occludin detected...
Biologically inspired structural color hydrogels with magnetic- and photothermal-controlled self-healable abilities were fabricated by integrating magnetic-responsive photonic crystals into gelatin hydrogels. The ability of the hydrogel systems was derived from magnetic response light-absorbing nanoparticles. When deteriorate or get damaged, nanoparticles could absorb heat under near-infrared irradiation external fields, which stimulates phase transformation in to fill heal In addition,...
In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(μ2-H2O)]·(Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4'-carboxylphenyl)-phthalic acid, Bpe 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection. Single-crystal X-ray diffraction analysis shows that CoII-MOF has two-dimensional (2D) bilayer structure composed Co2 units Dcpp4- ligands. There are two kinds in structure: one serves bidentate ligand...
Diabetic nephropathy (DN) is recognized as one of the primary causes chronic kidney disease and end-stage renal disease. Vaccarin (VAC) confers favorable effects on cardiovascular metabolic diseases, including type 2 diabetes mellitus (T2DM). Nonetheless, potential role mechanism VAC in etiology DN have yet to be completely elucidated. In this study, a classical mouse model T2DM experimentally induced via high-fat diet (HFD)/streptozocin (STZ) regimen. Renal histological changes are assessed...
Aberrant proliferation and inflammation of fibroblast-like synoviocytes (FLSs) significantly contribute to the pathogenesis rheumatoid arthritis (RA). Deficiency hydrogen sulfide (H2S) is a driving force for development RA, short half-life H2S-releasing donor sodium hydrosulfide (NaHS) limits its clinical application in RA therapy. Designing targeted delivery system with slow-release properties FLSs could offer novel strategies treating RA. Herein, we designed strategy achieve slow release...
The relatively higher temperature of the tumor site and responsive shape transition pNIPAM hydrogel make controllable drug release possible for oncotherapy.
Abstract Seven in absentia homolog1 (SIAH1) was reported as a tumor suppressor and played an important role regulating cell apoptosis. However, its effects on the breast carcinogenesis remain unclear. In this study, our aims were to examine relationship between SIAH1 Bcl‐2‐interacting mediator of death (Bim) explore carcinogenesis. Immunohistochemical analysis 231 cases tissues showed that expression Bim significantly decreased Moreover, correlated with Bim. Both higher well moderately...
Seven in absentia homolog 1 (SIAH1), a homologue of Drosophila seven (Sina), has emerged as tumor suppressor and plays an important role regulating cell apoptosis. To investigate the possible mechanism SIAH1 breast cancer cells, we up-regulated expression using pcDNA3-myc-SIAH1 knocked down siRNA. We found that overexpression induced apoptosis by up-regulating level Bim through activation JNK signaling pathway, suppression increased invasion via ERK pathway cells. All these results indicate...
This article presented a novel tumor-microenvironment-responsive particles delivery system with metformin-loaded chitosan inverse opal core and manganese dioxide shell for inhibiting PD-1/PD-L1 signaling pathway promoting tumor immunotherapy.