A5079990322- Ion Transport and Channel Regulation
- Immune Cell Function and Interaction
- Vitamin D Research Studies
- Natural Antidiabetic Agents Studies
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Metabolism, Diabetes, and Cancer
- Sleep and Wakefulness Research
- Hormonal Regulation and Hypertension
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects of Natural Compounds
- Wound Healing and Treatments
- Immune cells in cancer
- Phytochemistry and Bioactivity Studies
- Adenosine and Purinergic Signaling
- Mechanisms of cancer metastasis
- Antioxidant Activity and Oxidative Stress
- FOXO transcription factor regulation
- Renin-Angiotensin System Studies
- Morinda citrifolia extract uses
- Sodium Intake and Health
- Bioactive natural compounds
- Cancer-related cognitive impairment studies
Jiangnan University
2017-2024
University of Tübingen
2015-2017
Shaanxi Normal University
2012-2016
Oxidized low-density lipoprotein (ox-LDL) accumulation is one of the critical determinants in endothelial dysfunction many cardiovascular diseases such as atherosclerosis. C1q/TNF-related protein 9 (CTRP9) identified to be an adipocytokine with cardioprotective properties. However, potential roles CTRP9 function remain largely elusive. In present study, effects on proliferation, apoptosis, migration, angiogenesis, nitric oxide (NO) production and oxidative stress human umbilical vein cells...
Regulatory T cells (Tregs) are essential for maintaining an effective immune tolerance and a homeostatic balance of various other cells. To manipulate the response during infections autoimmune disorders, it is to know which genes or key molecules involved in development Tregs. Transcription factor Foxp3 required Tregs governs most suppressive functions these Inhibited PI3K/AKT/mTOR signalling critical stability. Previous studies have suggested that DJ-1 PARK7 protein positive regulator...
Background/Aims: Regulatory T cell (Treg) is required for the maintenance of tolerance to various tissue antigens and protect host from autoimmune disorders. However, Treg may, indirectly, support cancer progression bacterial infections. Therefore, a balance function pivotal adequate immune responses. Acid sphingomyelinase (ASM) rate limiting enzyme involved in production ceramide by breaking down sphingomyelin. Previous studies T-cells have suggested that ASM CD28 signalling, lymphocyte...
Abstract Sympathetic overdrive, activation of renin angiotensin systems (RAS), and oxidative stress are vitally involved in the pathogenesis hypertension cardiovascular remodeling. We recently identified that vaccarin protected endothelial cell function from or high glucose. In this study, we aimed to investigate whether attenuated Two‐kidney one‐clip (2K1C) model rats were used, low dose (10 mg/kg), (30 captopril mg/kg) intraperitoneally administrated. Herein, showed 2K1C exhibited higher...
Cardiovascular complications are a major leading cause of mortality in patients suffering from type 2 diabetes mellitus (T2DM). Vascular endothelial dysfunction is core pathophysiological event the early stage T2DM and eventually leads to cardiovascular disease. Vaccarin (VAC), an active flavonoid glycoside extracted vaccariae semen, exhibits extensive biological activities including vascular cell protection effects. However, little known about whether VAC involved regulation under high...
Background /Aims: Accumulating evidence indicates that endothelial inflammation is one of the critical determinants in pathogenesis atherosclerotic cardiovascular disease. Our previous studies had demonstrated Vaccariae prevented high glucose or oxidative stress-triggered dysfunction vitro. Very little known about potential effects hypaphorine from seed on inflammatory response cells. Methods: In present study, we evaluated anti-inflammatory (VH) lipopolysaccharide (LPS)-challenged EA.hy926...
The K(+),H(+) ionophore and antibiotic nigericin has been shown to trigger apoptosis is thus considered for the treatment of malignancy. Cellular mechanisms involved include induction oxidative stress, which known activate erythrocytic Ca(2+)-permeable unselective cation channels leading Ca(2+) entry, increase in cytosolic activity ([Ca(2+)]i) subsequent stimulation eryptosis, suicidal erythrocyte death characterized by cell shrinkage membrane scrambling with phosphatidylserine translocation...
Background/Aims: Dendritic cells (DCs), antigen-presenting critically important for primary immune response and establishment of immunological memory, are activated by bacterial lipopolysaccharides (LPS) resulting in stimulation Na+/H+ exchanger, ROS formation migration. The effects dependent on phosphoinositide 3 (PI3) kinase paralleled Akt phosphorylation. present study explored the contribution isoform Akt1. Methods: Cytosolic pH (pHi)...
DJ‐1/Park7 is a redox‐sensitive chaperone protein counteracting oxidation and presumably contributing to the control of oxidative stress responses thus inflammation. DJ‐1 gene deletion exacerbates progression Parkinson's disease by augmenting stress. Formation reactive oxygen species (ROS) paralleled activation Na + /H exchanger 1 (NHE1). ROS formation in CD4 T cells plays decisive role regulating inflammatory responses. In present study, we explored whether expressed cells, affects...
Activation of T cell receptors (TCRs) in CD4+ cells leads to a cascade signalling reactions including increase intracellular calcium (Ca2+) levels with subsequent Ca2+ dependent stimulation gene expression, proliferation, motility and cytokine release. The cytosolic results from release activation store-operated entry (SOCE). Previous studies suggested miRNAs are required for the development functions cells. An enzyme called Dicer is during process manufacturing mature precursor miRNAs. In...
Lung cancer always ranks first in the number of deaths every year, accounting for 18.4% total 2018. Metastasis is main cause death lung patients. The identification bioactive components traditional Chinese medicine very important development novel reagents against non-small cell (NSCLC). Rosthorin A has originated from Rabdosia rosthornii (Diels) Hara which excerpts ‘Chinese materia medica’, and known to have ‘clear heat phlegm’ properties folk. Little about biological functions mechanisms...
Abstract Many clinical studies have reported that patients diagnosed with cancer will suffer from sleep disturbance during their process, especially among lung patients, and this effect not easily subside. 1,25‐dihydroxy‐vitamin‐D 3 [1,25(OH) 2 D ], the activated form of vitamin D, can participate in neuronal differentiation prevent damage to nervous system. However, little is known about potential therapeutic effects cancer‐related psychiatric symptoms. In light this, we hypothesized a low...
Pyropolyporus fomentarius (L. ex Fr.) Teng is a unique woody mushroom due to its medicinal value with numerous pharmacological activities. This study presented the potential antitumor and immunomodulatory properties of ethanol extract P. fomentarius. The results showed that inhibited viability murine leukemia L1210 cells in dose-dependent manner IC50 69.35 μg/ml. Flow cytometry analysis demonstrated induced apoptosis cells. Additionally, decline mitochondrial membrane was observed as well...