A5101816789- Magnesium in Health and Disease
- Parathyroid Disorders and Treatments
- Fibroblast Growth Factor Research
- Lung Cancer Research Studies
- Wnt/β-catenin signaling in development and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Ion Channels and Receptors
- Pharmacological Effects of Natural Compounds
- Ubiquitin and proteasome pathways
- Parvovirus B19 Infection Studies
- Blood groups and transfusion
- Virus-based gene therapy research
- Hippo pathway signaling and YAP/TAZ
- Prenatal Screening and Diagnostics
- Medicinal plant effects and applications
- Kruppel-like factors research
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Complement system in diseases
- Prostate Cancer Treatment and Research
- Morinda citrifolia extract uses
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Cancer Treatment and Pharmacology
- Hemoglobinopathies and Related Disorders
Martin Luther University Halle-Wittenberg
2015-2017
University of Tübingen
2009-2016
University Health Network
2012
Ontario Institute for Cancer Research
2012
The fibroblast growth factor (FGF23) plasma level is high in cardiac and renal failure associated with poor clinical prognosis of these disorders. Both diseases are paralleled by hyperaldosteronism. Excessive FGF23 levels hyperaldosteronism further observed Klotho-deficient mice. present study explored a putative aldosterone sensitivity Fgf23 transcription secretion the involvement sensitive serum & glucocorticoid inducible kinase SGK1, SGK1 NFκB store operated Ca2+ entry (SOCE). Serum were...
Recently, we reported that membrane androgen receptors (mARs) are expressed in colon tumors triggering strong apoptotic responses. In the present study, analyzed mAR-induced downstream effectors controlling cell survival and migration of Caco2 cancer cells. We show long-term activation mAR downregulated activity PI-3K Akt induced dephosphorylation/activation proapoptotic Bad (p-Bad). Moreover, treatment APCMin/+ mice, which spontaneously develop intestinal tumors, with mAR-activating...
Significance The PI3 kinase-dependent inactivation of glycogen synthase kinase (GSK) 3 is an important aspect normal insulin signaling. Surprisingly, transgenic mice expressing kinase-resistant GSK3 (gsk3 KI ) have been found not to be insulin-resistant. We show that gsk3 are even protected from the development metabolic syndrome characterized by resistance, obesity, and dyslipidemia, which all could readily induced a high-fat diet in WT mice. affects millions patients associated with high...
Regulatory T cells (Tregs) are essential for maintaining an effective immune tolerance and a homeostatic balance of various other cells. To manipulate the response during infections autoimmune disorders, it is to know which genes or key molecules involved in development Tregs. Transcription factor Foxp3 required Tregs governs most suppressive functions these Inhibited PI3K/AKT/mTOR signalling critical stability. Previous studies have suggested that DJ-1 PARK7 protein positive regulator...
Infection with parvovirus B19 (B19) may induce apoptosis resulting in anemia, acute fulminant liver failure, placental insufficiency and myocarditis. Apoptosis has been attributed to proapoptotic activity of the non-structural viral protein NS1, which is known trigger a signaling cascade eventually leading activation caspases. In several cell types was found be paralleled by profound cytosolic acidification, secondary inhibition Na+/H+ exchanger. The acidification considered support pH...