A5101572837- Aortic aneurysm repair treatments
- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Esophageal and GI Pathology
- Wound Healing and Treatments
- Foreign Body Medical Cases
- Tracheal and airway disorders
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- CRISPR and Genetic Engineering
- Diet, Metabolism, and Disease
- Plant Molecular Biology Research
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Signaling Pathways in Disease
- Glutathione Transferases and Polymorphisms
- Sirtuins and Resveratrol in Medicine
Wuxi Fourth People's Hospital
2023-2025
Jiangnan University
2017-2025
Zunyi Medical University
2024
Peking University
2023-2024
First Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Center for Life Sciences
2023-2024
Ningbo University
2021-2024
Peking University People's Hospital
2024
Southern Medical University
2023-2024
Nanjing Medical University
2016-2024
Contrast-induced acute kidney injury (CI-AKI) is the third leading cause of hospital-acquired injury. Cellular senescence associated with CI-AKI. P16
Purpose To explore the potential role and unclear molecular mechanisms of vaccarin in wound healing. Methods Rats' skin excision model to study effects on healing vivo . Hematoxylin eosin staining was performed evaluate Histopathologic characteristics. Immunohistochemistry employed assess accelerating angiogenesis. Western blot used relative protein expressed levels. Results Vaccarin could significantly promote endothelial cells fibroblasts proliferation site. studies showed that nodal...
Some immune system cells express type A and/or B γ-aminobutyric acid receptors (GABAA-Rs GABAB-Rs). Treatment with GABA, which activates both GABAA-Rs and GABAB-Rs), a GABAA-R-specific agonist inhibits disease progression in mouse models of 1 diabetes (T1D), multiple sclerosis, rheumatoid arthritis, COVID-19. Little is known about the clinical potential specifically modulating GABAB-Rs. Here, we tested lesogaberan, peripherally restricted GABAB-R agonist, as an interventive therapy diabetic...
ABT-199, a specific inhibitor of the Bcl-2 protein, is widely used in clinical trials for hematological tumors and rarely applied to research solid tumors. In this study, we Bax/Bak double knockout (KO) knockdown (KD) cells as model found that ABT-199 initiated autophagic cell death independent Bax Bak. Beclin-1-dependent autophagy, which led death. Furthermore, inactivated Akt released Beclin-1 from 14-3-3 protein through change phosphorylation state ABT-199-treated cells. Moreover, JNK...
Lily is one of the most important cut flowers in world, with a rich floral fragrance. To further explore fragrance emission mechanisms lily cultivars, headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) and organic solvent extraction-gas (OSE-GC-MS) were used to unveil volatile compounds (VOCs) endogenous extracts seven cultivars. Furthermore, real-time quantitative PCR (qRT-PCR) was determine expression levels two key genes (TPS BSMT) related...
A year-round molecular epidemiological survey (2017 to 2018) was conducted on three hemoplasmas and two Bartonella species with zoonotic potential in client-owned cats Beijing Shanghai. Among 668 specimens, the overall hemoplasma-positive rate 4.9% (3.4% for Candidatus Mycoplasma haemominutum, 0.9% haemofelis 1.2% turicensis). The Bartonella-positive 8.5% (4.8% B. henselae 4.3% clarridgeiae). Age, breed, ectoparasiticide use stray history, but not city, season gender, were significantly...
Abstract In varicose veins, vascular smooth muscle cells (VSMCs) often show abnormal proliferative and migratory rates phenotypic transition. This study aimed to investigate whether microRNA (miR)‐202 its potential target, peroxisome proliferator–activated receptor‐γ coactivator‐1α (PGC‐1α), were involved in VSMC miR‐202 expression was analyzed veins VSMCs conditioned with platelet‐derived growth factor. The effect of on cell proliferation migration assessed. Furthermore, contractile marker...
The incidence of acute myocardial infarction (AMI) is increasing yearly. With the use thrombolysis or percutaneous coronary intervention (PCI), mortality rate has been significantly reduced. However, reperfusion can cause additional injury. There still a lack effective drugs to treat I/R injury, and it urgent find new therapeutic drugs.In this study, network pharmacology was used predict potential targets biological processes involved in Muscone-mediated treatment infarction. To model...
ABSTRACT Nasopharyngeal carcinoma (NPC) is a malignant tumor with high metastatic features originating from the nasopharynx. However, underlying mechanism of Suppressor variegation 3–9 homolog 2 (SUV39H2) in NPC remains poorly understood. RT‐qPCR was carried out to examine SUV39H2 and SIRT1 expression tissues cells. Kaplan–Meier method utilized evaluate association between level overall survival. The function cell viability, metastasis, apoptosis tested through CCK‐8, transwell, flow...
Interferon-gamma-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy synergistic effects.To elucidate mechanisms IP-10 gene agent, we intramuscularly injected pBLAST-IP-10 expression plasmid gemcitabine into tumor-bearing mice.The proliferation endothelial cells was effectively inhibited by in vitro. Treatment twice week for 4 weeks mg/kg (once week) resulted sustained high level serum,...
Biodegradable polymer materials are attractive in various biomedical applications. Herein, we report a block aliphatic copolymer, polycaprolactone-block-polyglycolide (PCL-b-PGA, denoted as PCLGA), and explored the composition effect on thermal degradation behaviors. Three copolymers with different PCL/PGA weight ratios were obtained by two-step ring opening polymerization. The chemical structures compositions of studied NMR FT-IR. behaviors investigated DSC TGA. vitro phosphate buffer...