A5100553912- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Inflammatory Biomarkers in Disease Prognosis
- Advanced biosensing and bioanalysis techniques
- Sepsis Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Inflammasome and immune disorders
- Tracheal and airway disorders
- Bone and Joint Diseases
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Heart Failure Treatment and Management
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Advanced Measurement and Metrology Techniques
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
Wuxi No.2 People's Hospital
2019-2025
Jiangnan University
2023-2025
Henan Provincial People's Hospital
2024-2025
Zhengzhou University
2024-2025
Qom University of Medical Science and Health Services
2024
University of Qom
2024
Nanjing Medical University
2013-2023
Wuxi Fourth People's Hospital
2023
Wuxi People's Hospital
2011-2022
Soochow University
2014-2022
Background: Red blood cell distribution width (RDW) is increased in liver disease. Its clinical significance, however, remains largely unknown. The aim of this study was to identify whether RDW a prognostic index for
miRNAs are known to play a crucial role in cardiac development, and the expression of miRNA is altered diseased heart. The aim this study was investigate value plasma microRNA-499 (miR-499) as novel biomarker for early diagnosis acute myocardial infarction (AMI).Enrolled were 227 patients with chest pain on presentation departments emergency cardiology Wuxi Second People's Hospital between October 2011 May 2014. Additional 100 healthy individuals who received physical examination same...
MicroRNA (miRNA) is reported to be present in human plasma and has been increasingly suggested as a biomarker for diseases. Our study aimed investigate the kinetics of cardiac-specific microR-499 (miR-499) acute myocardial infarction (AMI).Circulating concentrations cardiac enriched miR-499 were measured by quantitative PCR 73 patients with coronary syndrome (ACS), including 53 AMI 20 unstable angina (UA). Thirty healthy subjects used controls. Plasma samples group obtained immediately after...
Diabetic nephropathy (DN) is recognized as one of the primary causes chronic kidney disease and end-stage renal disease. Vaccarin (VAC) confers favorable effects on cardiovascular metabolic diseases, including type 2 diabetes mellitus (T2DM). Nonetheless, potential role mechanism VAC in etiology DN have yet to be completely elucidated. In this study, a classical mouse model T2DM experimentally induced via high-fat diet (HFD)/streptozocin (STZ) regimen. Renal histological changes are assessed...
Background Red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) have been reported be associated with outcomes of acute cerebral infarction. However, their prognostic value in patients subarachnoid haemorrhage (SAH) remains largely unknown. The aim this study was investigate the RDW NLR SAH patients. Methods Medical records adult admitted intensive care unit (ICU) were extracted from Multiparameter Intelligent Monitoring Intensive Care II (MIMIC II, version 2.6),...
Background: Growing evidence from studies elsewhere have illustrated that microRNAs (miRNAs) play important roles in Polymyositis and Dermatomyositis (PM/DM). However, little has been reported on their relationship with regenerating islet-derived protein 3-alpha (REG3A) as well associative macrophage migration. Therefore, this study sought to establish the association between miR-146a REG3A investigate functional migration PM/DM pathogenesis. Methods: Peripheral blood mononuclear cells...
Aberrant proliferation and inflammation of fibroblast-like synoviocytes (FLSs) significantly contribute to the pathogenesis rheumatoid arthritis (RA). Deficiency hydrogen sulfide (H2S) is a driving force for development RA, short half-life H2S-releasing donor sodium hydrosulfide (NaHS) limits its clinical application in RA therapy. Designing targeted delivery system with slow-release properties FLSs could offer novel strategies treating RA. Herein, we designed strategy achieve slow release...
Background Previous studies indicated that both red blood cell distribution width ( RDW ) and neutrophil to lymphocyte ratio NLR were useful indices in assessing the disease activity of autoimmune diseases. However, evidence for association between , dermatomyositis DM polymyositis PM is limited. The aim this study investigate / . Methods Medical records 114 patients healthy controls retrospectively reviewed, their myositis assessment visual analogue scale MYOACT on admission extracted....
MicroRNAs are present in human plasma and have been reported to be biomarkers for cardiovascular diseases. The aim of this study was investigate the value circulating microRNA-208b (miR-208b) diagnosis prognosis acute myocardial infarction (AMI).A total 100 AMI patients, 80 unstable angina (UA) healthy controls (HCs) were consecutively included study. Plasma collected from each participant on admission, levels miR-208b measured using reverse transcription-polymerase chain reaction (RT-PCR)....
Background: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome characterized by chronic inflammation, insulin resistance, and islet cell damage. The prevention of T2DM its associated complications an urgent public health issue that affects hundreds millions people globally. Numerous studies suggest disturbances in gut metabolites are important driving forces for the pathogenesis diabetes. However, functions mechanisms action most commensal bacteria remain largely unknown. Methods:...
The treatment of cancer has brought about a paradigm shift with the introduction immune checkpoint blockade (ICB) therapy, which is mostly dependent on inhibiting PD-1/PD-L1 and CTLA-4. However, recent studies have shown limited efficacy this in esophageal squamous cell carcinoma (ESCC). Preliminary found that tifcemalimab (the world's first anti-BTLA blocking monoclonal antibody) combined toripalimab (PD-1) chemotherapy favorable safety several solid cancers. This study aimed to evaluate...
Laparoscopic lateral pelvic lymph node dissection (LPND) is limited by complex neurovascular bundles in the narrow sidewall and various post-operative complications. Indocyanine green (ICG) has been applied to increase number of harvested nodes reduce injury irrelevant vessels patients with rectal cancer. However, few studies on recurrence rate ICG fluorescence imaging-guided laparoscopic LPND were reported. This retrospective study enrolled 50 middle- low cancer who treated LPND. After...
The family of Wnt proteins have been implicated in embryogenesis by regulation cell fate and pattern formation, also human carcinogenesis. Wnt10B was previously shown to be involved breast cancer development. present study assessed the association expression gastric tissue specimens with clinicopathological data from these patients. proliferation migration capacity vitro then investigated. revealed that mRNA protein were upregulated samples associated metastasizing lymph nodes. Knockdown...
Serum YKL-40 has been proved to be a promising biomarker for estimating the disease activity of several autoimmune diseases. However, its utility in polymyositis or dermatomyositis not established. The aim this study was investigate patients with polymyositis/dermatomyositis.Patients definite polymyositis/dermatomyositis who visited Second People's Hospital Wuxi between April 2016 and March 2017 were prospectively enrolled. Eighty-seven healthy individuals set as control. all participants...