A5100346502- Drug Solubulity and Delivery Systems
- Lung Cancer Treatments and Mutations
- Radioactive element chemistry and processing
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Drug Delivery Systems
- Lymphoma Diagnosis and Treatment
- Covalent Organic Framework Applications
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Blood properties and coagulation
- Retinal and Optic Conditions
- Drug Transport and Resistance Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Metabolism and Diseases
- Lung Cancer Diagnosis and Treatment
- Pharmacy and Medical Practices
- Surfactants and Colloidal Systems
- Cancer Treatment and Pharmacology
- Ocular Diseases and Behçet’s Syndrome
- Cardiac Imaging and Diagnostics
- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
- Pharmacological Effects of Natural Compounds
- Methemoglobinemia and Tumor Lysis Syndrome
- Flavonoids in Medical Research
Wannan Medical College
2024-2025
First Affiliated Hospital of Kunming Medical University
2015-2024
Kunming Medical University
2015-2024
Zhejiang University
2024
Soochow University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
China Agricultural University
2024
Second Affiliated Hospital of Soochow University
2024
Regeneron (United States)
2024
Liver fibrosis is a progression of chronic liver disease, which lacks effective therapies in the world. Attractively, more and evidences show that natural products are safe prevention treatment hepatic fibrosis. Artesunate, water-soluble hemisuccinate derivative artemisinin, exerts various pharmacological activities such as anti-inflammatory, anti-tumor immunomodulating abilities. However, effects artesunate on little-known. Here our study was performed to investigate effect carbon...
Aging is associated with an increased incidence and prevalence of renal glomerular diseases. Sirtuin (Sirt) 6, a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, has been shown to protect against multiple age-associated phenotypes; however it unknown whether Sirt6 direct pathophysiologic role in the kidney. In present study, we demonstrate that expressed kidney aging Sirt6-deficient mice exhibit hypertrophy enlargement. deletion induces podocyte injury, including...
Aim This study aimed to investigate the expression of CHI3L1 in aggressive lymphomas and assess its potential as a diagnostic prognostic biomarker. Methodology investigates protein peripheral blood patients with lymphoma healthy controls using enzyme-linked immunosorbent assay (ELISA). The significance was assessed through Cox regression Kaplan-Meier survival analyses. differences between control samples were analyzed lymphoma-related gene datasets GSE25638 GSE56315, well their combined...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hereditary disease that predisposes red blood cells to oxidative damage. G6PD particularly prevalent in historically malaria-endemic areas. Use of primaquine for malaria treatment may result severe hemolysis deficient patients. In this study, we systematically evaluated the prevalence Kachin (Jingpo) ethnic group along China-Myanmar border and determined underlying genotypes. We surveyed 1770 adult individuals (671 males 1099...
Puerarin, extracted from Radix puerariae, was reported to ameliorate airway inflammation, lung injury and fibrosis induced by paraquat (PQ) in mice. However, effects of puerariae extracts (RPEs) on or signalling pathways PQ-induced have not been well studied. Therefore, the goals our study were investigate whether are antifibrotic a model mice propose possible mechanisms action RPE effects.We used long-term exposure evaluate antioxidant-containing RPE. We examined miR-21 follistatin-like 1...
The associative structures of four β-cyclodextrins (βCD) derivatives with triblock copolymers polyethylene oxide (PEO)-polypropylene (PPO)-polyethylene (PEO) (Pluronics) were investigated by small-angle neutron scattering (SANS), wide-angle X-ray (WAXS) and Fourier transform infrared spectroscopy (FTIR). As shown in a previous study (J. Joseph, C. A. Dreiss, T. Cosgrove, J. S. Pedersen, Langmuir, 2007, 23, 460–466), the addition increasing amounts heptakis(2,6-di-O-methyl)-βCD (hep2,6-βCD)...
Post–heating operation is crucial to produce ambient yogurt, which also a direct cause of sensory defects, especially graininess. Consumers' perception graininess varies based on individual sensitivities. Accurate evaluation prerequisite for improving the quality yogurts. The purpose this study was propose method discriminate consumers' sensitivity grainy post–heating (55 °C–85 °C, 25 s) fermented milk, and further determine volume proportion threshold required different intensities by...
Primary liver cancer has consistently exhibited a high prevalence and fatality rate, necessitating the investigation of associated diagnostic markers inhibition mechanisms to effectively mitigate its impact. The significance apolipoprotein M (ApoM) in impeding progression neoplastic ailments is progressively gaining recognition. However, comprehensive understanding underlying mechanism advancement remains be elucidated. Recent evidence indicates potential association between ApoM...
β-amyloid peptide (Aβ) is one of the main protein components senile plaques contributing to Alzheimer's disease and it can induce neuronal apoptosis. In this study, was found that icariin, a flavonoid extracted from Chinese Herba-Epimedii, inhibited Aβ42-induced neurotoxicity in dose-dependent manner. The peak dose icariin 160 μg/ml. addition, mRNA expressions cocaine amphetamine-regulated transcript (CART) were increased Aβ42-treated neurons presence 80 μg/ml icariin. Moreover, CART–RNA...
Xuebijing injection (XBJ) has long been used to treat infectious diseases in China. The therapeutic effect of XBJ is probably associated with anti-inflammatory effects. However, the precise mechanisms responsible for effects remain unknown. present study was conducted order evaluate protective a rat model D-galactosamine (D-Gal)- and lipopolysaccharide (LPS)‑induced acute liver injury. In study, rats were injected D-Gal LPS intraperitoneally induce Two hours prior administration, treatment...
A two-step dual-wavelength phase imaging method with total variation (TV) regularization in digital holographic microscopy (DHM) is presented. The rough height map first denoised TV regularization, and then it used as a guiding for accurate unwrapping. By combining the principle of interferometry problem unwrapping converted into minimization that can be efficiently solved Split Bregman algorithm. proposed algorithm allows synthetic wavelength arbitrarily large to single wavelength, while...
Background and Objective The objective of this study was to investigate the possible roles clusters differentiation 147 ( CD 147) in bone resorption mineralization through markers sialoprotein, osteocalcin, osteopontin alkaline phosphatase ALP ), trabecular structure alveolar number osteoclasts. We also investigated effects on inflammation collagen breakdown. Material Methods Twenty‐eight male Wistar rats were randomly divided into four groups seven animals each: healthy group, periodontitis...
Airway remodeling in asthma contributes to airway hyperreactivity, loss of lung function and persistent symptoms. Current therapies do not adequately treat the structural changes associated with asthma. Statin drugs have improved respiratory health their therapeutic potential has been tested clinical trials. However, mechanism action statins this context remained elusive. The present study hypothesized that atorvastatin treatment ovalbumin-exposed mice attenuates early features via a...
<b><i>Objectives:</i></b> This study's aim was to evaluate the protective effects of salvianolate on contrast-induced nephropathy after primary percutaneous coronary intervention (PPCI) compared with normal saline (NS) hydration. <b><i>Methods:</i></b> We enrolled patients acute myocardial infarction who underwent PPCI in 3 centers Shanghai. The were randomly assigned group or NS group. incidence CIN, changes renal function parameters, and...