A5101770355- Pregnancy and preeclampsia studies
- Thyroid Disorders and Treatments
- Soybean genetics and cultivation
- Reproductive System and Pregnancy
- Growth Hormone and Insulin-like Growth Factors
- Antibiotic Resistance in Bacteria
- Pregnancy-related medical research
- Congenital Heart Disease Studies
- Genetic Mapping and Diversity in Plants and Animals
- Sepsis Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular Conditions and Treatments
- Fuel Cells and Related Materials
- Wireless Power Transfer Systems
- Metabolism and Genetic Disorders
- Endometrial and Cervical Cancer Treatments
- Infectious Encephalopathies and Encephalitis
- Pregnancy and Medication Impact
- Lipid metabolism and disorders
- Bariatric Surgery and Outcomes
- Paraquat toxicity studies and treatments
- Cancer Risks and Factors
- Bone and Joint Diseases
- Ethnobotanical and Medicinal Plants Studies
Tongde Hospital of Zhejiang Province
2024-2025
Soochow University
2009-2024
First Affiliated Hospital of Kunming Medical University
2015-2024
Kunming Medical University
2015-2024
Hospital of Hebei Province
2023
Chengde Medical University
2022-2023
Zhengzhou University
2020-2022
Henan Provincial People's Hospital
2022
Henan University
2022
Dongyang People's Hospital
2017
Rationale: Carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections are a severe complication resulting from granulocyte deficiency following chemotherapy for hematologic malignancies and have high mortality rate. However, reports of disseminated organ secondary to rare. Patient concerns diagnoses: We report 2 cases patients with acute lymphoblastic leukemia who both developed CRKP during the stage chemotherapy, 1 case bacterial liver abscess septic arthritis. Interventions...
Background: Graves' disease (GD) is an autoimmune thyroid disorder. Our previous study has demonstrated a significant decrease in flavone levels among children with GD compared to the control group. Puerarin, well-known flavonoid anti-inflammatory and antioxidant properties. We wanted investigate its potential impact on pathogenesis, aiming determine whether increasing puerarin intake could prevent or delay onset of GD. Methods: Adenovirus TSHR-289 subunit was used establish mice model, were...
Rationale: Immune thrombocytopenia (ITP) is an autoimmune-mediated disorder caused by antibody-mediated platelet destruction and impaired production megakaryocytes. Treating refractory ITP remains a significant challenge. Patient Concerns Diagnoses: We report 2 patients with ITP. Interventions Outcomes: Two received low-dose decitabine combined recombinant human thrombopoietin or eltrombopag. Platelet counts in both increased to within the normal range. Lessons: Low-dose eltrombopag may...
Puerarin, extracted from Radix puerariae, was reported to ameliorate airway inflammation, lung injury and fibrosis induced by paraquat (PQ) in mice. However, effects of puerariae extracts (RPEs) on or signalling pathways PQ-induced have not been well studied. Therefore, the goals our study were investigate whether are antifibrotic a model mice propose possible mechanisms action RPE effects.We used long-term exposure evaluate antioxidant-containing RPE. We examined miR-21 follistatin-like 1...
Abstract Background Soybean is a globally important legume crop that provides primary source of high-quality vegetable protein and oil. Seed content (SPC) valuable quality trait controlled by multiple genes in soybean. Results In this study, we performed quantitative loci (QTL) mapping, QTL-seq, RNA sequencing (RNA-seq) to reveal the controlling soybean using high variety Nanxiadou 25. A total 50 QTL for SPC distributed on 14 chromosomes except 4, 12, 14, 17, 18, 19 were identified mapping...
Abstract Background This study aimed to investigate the effects of LINC00240/miR-155/Nrf2 axis on trophoblast function and macrophage polarization in pathogenesis preeclampsia. Methods Bindings between LINC00240, miR-155 Nrf2 were validated by dual luciferase reporter assay or RNA-immunoprecipitation. Cell proliferation, migration, invasion, pyroptosis detected CCK-8, clone formation, wound healing, Transwell system, flow cytometry, respectively. Macrophage was tested cytometry. The...
Background Complex interconnections are evident among gut microbiota, circulating metabolites, inflammatory cytokines, and the pathogenesis of abdominal aortic aneurysms (AAA), with causal dynamics yet to be comprehensively elucidated. The primary objective this study was elucidate potential relationships involving microbiota-mediated plasma AAA.
Heng-Gu-Gu-Shang-Yu-He-Ji, also known as OsteoKing, is used a herbal Traditional Chinese Medicine for the treatment of bone disease, including femoral head necrosis and osteoarthritis. However, whether OsteoKing has anti-osteoporotic properties remained to be elucidated. The purpose present study was therefore investigate effects on ovariectomy-induced osteoporosis in rabbits. Female New Zealand white rabbits were randomly divided into an ovariectomized (OVX) group sham-surgery group. OVX...
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a highly aggressive subtype of T-ALL. No standard chemotherapy regimen exists for patients with recurrent/refractory (R/R) ETP-ALL; in these patients, the primary goal salvage therapy to achieve remission as foundation consolidation and intensification treatments. This study reports cases two R/R ETP-ALL who underwent venetoclax combined CAG achieved complete bone marrow. Flow cytometry results were negative minimal residual...
Abstract Objectives Graves’ disease (GD) is an autoimmune involving intimate response of both T cells and B cells. Immunophenotyping peripheral blood lymphocyte subsets in GD children with different clinical characteristics can provide further information the pathogenesis GD. Methods We studied 141 repeatedly divided patients into two groups accordance (abnormal or normal alanine aminotransferase (ALT) levels, presence absence orbitopathy (GO), hematuria. Then we compared measurements...
Osteoporosis (OP) treatment has always been challenging for elderly menopausal females. An animal model with a closer genetic association to human OP is essential research. Given its close primates, the tree shrew suitable candidate meeting requirements such an model. In present study, induced by ovariectomy (OVX), was established. Evaluation multiple analysis methods, including blood biochemical indicators, uterus coefficients, micro‑computed tomography analysis, histochemical and scanning...
Objective Graves’ disease (GD) related hyperthyroidism (HT) has profound effects on metabolic activity and metabolism of macromolecules affecting energy homeostasis. In this study, we aimed to get a comprehensive understanding the changes their clinical relevance in GD children. Methods We investigated serum substances from 30 newly diagnosed children age- gender-matched healthy controls. explored metabolomics using ultra-high-performance liquid chromatography–quadrupole time-of-flight mass...
Tree shrews are most closely related to the primates and so possess a number of advantages in experimental studies; they have been used as an animal model bacterial virus infection, cancer, endocrine system disease, certain nervous diseases. Their olfactory ensheathing cells (OECs) able release several cytokines promote neuronal survival, regeneration remyelination. The present study western blot analysis identify antibody specificity protein extracts from whole tree shrew brains p75 nerve...
<title>Abstract</title> Sepsis-induced cardiomyopathy (SIC) is a kind of cardiac dysfunction caused by severe sepsis, which increases the risk heart failure and death. The molecular mechanism its pathogenesis still unclear. It reported that oxidative stress one main pathophysiological manifestations SIC, suggesting genes may be involved in myocardial injury SIC. Therefore, we discussed relationship between gene order to provide reference for clinical diagnosis or treatment Through...
Metagenomic next-generation sequencing (mNGS) is a new high-throughput method that may have great importance in early diagnosis and clinical management of sepsis. This study aimed to detect the difference between mNGS comprehensive routine microbiological test (CMT), explore diagnostic efficacy septic patients. retrospectively analyzed 150 sepsis patients who were admitted intensive care units 4 hospitals Southwest China from October 1, 2018, 2021, underwent both blood CMT. The demographic...
Background: Traumatic brain injury (TBI) is a major cause of disability worldwide, without definitive and effective intervention. Dexmedetomidine (DEX) has neuroprotective effect against TBI; however, the detailed mechanism underlying this remains unclear. Methods: Ten male Sprague Dawley rats were used to establish TBI model. The randomly divided into two groups: group (TBI, control group) DEX treatment (DEX). next day, neurological function evaluated by modified severity score (mNSS)....
This study aimed to investigate the roles of lysine (K)-specific demethylase 5C (KDM5C)-bone morphogenetic protein-7 (BMP-7) signaling pathway in pathogenesis severe preeclampsia (sPE). A total 180 pregnant patients were enrolled and classified into three groups: an early-onset sPE group (EOsPE) (n = 60), a late-onset (LOsPE) control (normal pregnancy; n 60). The messenger RNA (mRNA) protein expression levels bone receptor II (BMPRII), BMP-7, KDM5C detected placenta samples from two groups,...
The objective of this study was to evaluate the effect maturing fetal lung on clinical efficacy acetaminophen in treatment premature infants with patent ductus arteriosus (PDA). A total 441 admitted our hospital from May 2020 2021 were recruited, including 152 receiving maturation (13 cases PDA closure drug use and 2 failed) 289 without (17 8 failed). Finally, a 30 enrolled trial. All divided into groups B according whether adopted before delivery. In group A, 13 received maturation, 17 did...
Compared with the early symptoms of non-pregnancy, pregnancy cervical cancer is often confused threatened abortion, so it difficult to diagnose and delay time treatment. At present, compared cancer, there no clear standard treatment for in pregnancy. diagnosis plan mainly made according pathological examination, staging, fetal development (whether abnormality on ultrasound whether chromosome karyotype normal or not) pregnant women their family members' wishes. A case complicated who was...