A5056102524- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- CAR-T cell therapy research
- Retinoids in leukemia and cellular processes
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Multiple Myeloma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Synthesis and biological activity
- Cancer-related Molecular Pathways
- Periodontal Regeneration and Treatments
- FOXO transcription factor regulation
- Eosinophilic Disorders and Syndromes
- PI3K/AKT/mTOR signaling in cancer
- Blood properties and coagulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Lymphatic System and Diseases
- PARP inhibition in cancer therapy
- Parvovirus B19 Infection Studies
- Liver physiology and pathology
Montefiore Medical Center
2018-2024
The University of Texas MD Anderson Cancer Center
2023
Albert Einstein College of Medicine
2021-2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
First Affiliated Hospital of Soochow University
2018-2021
Soochow University
2018-2021
Tianjin Medical University
2010-2019
Second Hospital of Tianjin Medical University
2010-2019
First Affiliated Hospital of Zhengzhou University
2017-2018
The distance metastases of papillary thyroid carcinoma (PTC) were a major threaten for PTC patients, thus, to study the potential mechanism treatment was essential. Previous studies have shown that PTCSC3 (Thyroid Carcinoma Susceptibility Candidate 3), miR-574-5p and Wnt/β-catenin involved in PTC, but pathogenic among them still unclear. Real-time PCR Western blot used detect genes expression. Luciferase reporter assay combination suppressor cancer cell invasion (SCAI), as well ratio...
Transcription factors and cofactors play critical roles in cell growth differentiation. Alterations of their activities either through genetic mutations or by viral oncoproteins often result aberrant tumorigenesis. The transcriptional cofactor p300 has recently been shown to be complexed with transcription YY1 CREB. Adenovirus E1A target these complexes via physical interactions p300, resulting alterations mediated factors. Here we show that is also for repression the cJun JunB, two members...
Multimodal Large Language Models (MLLMs) have shown significant advancements, providing a promising future for embodied agents. Existing benchmarks evaluating MLLMs primarily utilize static images or videos, limiting assessments to non-interactive scenarios. Meanwhile, existing AI are task-specific and not diverse enough, which do adequately evaluate the capabilities of MLLMs. To address this, we propose EmbodiedEval, comprehensive interactive evaluation benchmark with tasks. EmbodiedEval...
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and chemoresistance main obstacle for effective treatments HCC. Accumulating studies indicated that long non-coding RNAs (lncRNAs) contribute to human carcinoma. However, functional role HANR in autophagy-mediated HCC unknown.The expressions HANR, miR-29b ATG9A tissues cell lines were detected by real-time quantitative PCR (RT-qPCR). The expression autophagy-related protein LC3-I LC3-II was evaluated Western...
Objectives: Long non-coding RNA (lncRNA) associated with microvascular invasion in hepatocellular carcinoma (MVIH) has been recently reported to act as a predictor for the poor recurrence-free survival of (HCC) after hepatectomy. However, biological role MVIH tumorigenesis HCC is still unclear. Methods: In study here, expression levels were detected by real-time polymerase chain reaction (PCR) tumor tissue patients and cells, including SMMC7721 HepG2 cells. Cell viability apoptosis...
Abstract The long noncoding RNA HANR has been shown to be involved in the progression of hepatocellular carcinoma (HCC). However, underlying mechanism HCC‐associated (HANR)–regulated HCC metastasis and lymphangiogenesis not elucidated. RT‐qPCR Western blot methods were utilized detect gene expressions. Interaction with miR‐296 was predicted by a bioinformatic program validated dual‐luciferase reporter assay. For functional experiment, transwell invasion assay examine abilities HepG2 Huh‐7...
Hepatocyte nuclear factor-1beta plays an important role in the development and progression of liver cancer. In recent years, expression HNF-1β has been reported to be associated with risk for a variety cancers. The purpose this study is investigate whether promotes malignancy HCC its mechanism. We retrospectively investigated 90 patients hepatocellular carcinoma found that high indicated poor prognosis. overexpressed cancer cell lines progenitor markers stemness were upregulated. invasion...
The present study focused on exploring the inhibitory mechanism of microRNA (miR)-23a in endometrial cancer. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used to investigate miR-23a expression tissues and cancer cells. A colony formation assay using crystal violet staining performed compare cell proliferation, while wound-healing Transwell assays were migration invasion. Subsequently, bioinformatics a luciferase reporter gene effect sine oculis homeobox homolog...
Adoptive immunotherapy using CD19-targeted Chimeric antigen receptor T cells (CAR-T) has revolutionized the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Data is limited on propensity infections and lymphohematopoietic reconstitution after Day 30 (D30) following CAR-T cell therapy. In this study, we evaluated prevalence nature infectious complications in an expanded cohort DLBCL patients treated with CD19 therapy its association dynamics leukocyte subpopulation...
Constitutive activation of signal transducers and activators transcription (STAT) 3 has been observed in many solid tumors including head neck squamous cell carcinoma. Expression STAT3 laryngeal carcinoma have not fully understood. The study aims to investigate the expression carcinoma, relationship between activated its downstream target gene CyclinD1 related clinicopathological factors STAT3.Prospective.Sixty-four samples 12 control mucosa obtained from total laryngectomy cases were...
p53 together with its downstream product p21 plays an important role in tumorigenesis development. MDM2 and MDM4 are two regulators. We studied the expression of p53, p21, MDM2, a total 120 cases myeloid neoplasms including MDS, AML or MDS/MPN, control, using single double immunohistochemical stains. found TP53 mutations had worse outcome patients AML/MDS, detected by immunohistochemistry similar prognostic value. was strongly related to mutation status, loss almost all mutated cases. were...
Airway remodeling in asthma contributes to airway hyperreactivity, loss of lung function and persistent symptoms. Current therapies do not adequately treat the structural changes associated with asthma. Statin drugs have improved respiratory health their therapeutic potential has been tested clinical trials. However, mechanism action statins this context remained elusive. The present study hypothesized that atorvastatin treatment ovalbumin-exposed mice attenuates early features via a...
The purpose of this study was to determine whether contrast-enhanced sonography can be used differentiate histopathologic grades hepatocellular carcinoma.This included 54 patients with carcinomas. All underwent fundamental and sonographic examinations. Auto-tracking contrast quantification software the arrival time, time peak, peak intensity, wash-out enhancement slope, clearance slope lesions. lesions were confirmed by surgery. carcinoma divided into 2 groups according World Health...
Engineering of a vascularized bone construct is highly challenging task which needs to take into account the impact different components on regeneration process. Bone repair influencing factors in such constructs range from material properties and scaffold design, interaction cell types contributing formation remodeling or neovascularization, respectively. In this context, early endothelial progenitor cells (EPC), mononuclear isolated peripheral blood, express marker CD31 but also series...
Sorafenib (SOR) resistance is still a significant challenge for the effective treatment of hepatocellular carcinoma (HCC). The mechanism sorafenib remains unclear. Several microRNAs (miRNAs) have been identified as playing role in impairing sensitivity tumor cells to treatment. We examined behind miR-92b mediating HCC cells. detected that expression was significantly upregulated SOR-resistant HepG2/SOR compared parental HepG2/WT After transfection with inhibitor, proliferation remarkably...
Anaplastic myeloma (AM) is an extremely rare and aggressive histological variant of myeloma. It characterized by extramedullary presentation in the young has a poor prognosis. can be diagnostic challenge when not suspected even more immunophenotype unexpected. We present anaplastic with cardiovascular involvement. Though patient did have typical clinical features myeloma, except lytic lesion femur, cardiac biopsy showed sheets cells, some multinucleation. There were also areas plasmacytoid...
To investigate the effects of pirfenidone on CCl4-induced liver fibrosis in mice.After 8-week feeding, 40 healthy male SPF ICR mice were randomly divided into 4 groups:liver group (CCL4 group), low doses Pirfenidone (PFD-L high (PFD-H group) and control group. The CCL4 group, injected intraperitoneally with 0.4 ml 10% solution dissolved soybean oil. Then PFD-L PFD-H groups treated 120 mg 240 PFD via gastric gavage, respectively. Control was same volume saline. Alanine aminotransferase(ALT),...
To observe the effect of AdipoRon for treatment type 2 diabetes (T2DM)in mice and its on liver.Forty male C57/BL6 (SPF) were randomly divided to normal control (NC) group experimental group. establish T2DM model, in fed with high fat glucose, combined intraperitoneal injection streptozotocin (STZ) small doses, further subdivided into model (DM) group, low (DM+L) (DM+H) (n=10). Serum indexes, such as levels alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP) detected...
SOS is a rare complication of stem cell transplantation and has significant morbidity mortality. We present three cases highlight underlying risk factors for its development, such as impaired clearance alkylating agents (especially melphalan) in patients with renal failure prolonged infection. Although, melphalan cyclophosphamide cause less commonly than busulfan, physicians must use caution when administering these drugs to comorbidities that may increase the likelihood development SOS....