A5103076397- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Glycosylation and Glycoproteins Research
- PI3K/AKT/mTOR signaling in cancer
- Alzheimer's disease research and treatments
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- RNA and protein synthesis mechanisms
- Chemical synthesis and alkaloids
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Galectins and Cancer Biology
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Ferroptosis and cancer prognosis
- Phosphorus compounds and reactions
- Organophosphorus compounds synthesis
- Animal Genetics and Reproduction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Chromatin Dynamics
Affiliated Hospital of Nantong University
2022-2024
Nantong University
2022-2024
Soochow University
2016-2021
First Affiliated Hospital of Soochow University
2016-2021
Shanghai Ocean University
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
1992
Pediatrics and Genetics
1986
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a type of long noncoding RNA. It associated with metastasis and favorable prognostic factor for cancer. Recent studies have shown that MALAT1 plays an important role in other malignancies. But, little known about the glioma. In this study, quantitative reverse transcription PCR (qRT-PCR) was used to demonstrate expression lower than normal brain tissues. Stable RNA interference-mediated knockdown human glioma cell lines (U87...
Colon adenocarcinoma (COAD) is a highly lethal gastrointestinal malignancy. The five-year survival rate of metastatic colorectal cancer remains low, at 14 percent. Numerous publications have suggested role for peroxisome proliferator-activated receptors (PPARs) in Recent studies shown that PPARs, as nuclear transcription factors, may serve potential targets the treatment metabolic syndrome tumors and their associated complications. However, molecular mechanism has not been thoroughly...
Abstract Background PI4K2A has been found to have a tumor‐promoting role in various solid tumors and be involved biological procedures. In this article, we aim investigate the prognostic values of provide new insights colon adenocarcinoma (COAD). Methods The Cancer Genome Atlas (TCGA) database, Human Protein online UALCAN database were used analyze expression COAD survival patients. Univariate multifactorial Cox regression analyses assess prognosis on COAD. GSEA was explore PI4K2A‐related...
The physical location of the mouse IFN-α locus (<i>Ifa</i>) on chromosome 4 was defined by in situ hybridization a cloned probe to metaphase spreads which one present as part single metacentric chromosome, all other chromosomes being acrocentric. (This approach greatly facilitates analysis and can be used even when it is difficult obtain good banding.) Using unhanded chromosomes, grains were localized over metacentric, region 0.61 + 0.07 (SD) distance from centromere telomere. In...
Sorafenib (SOR) resistance is still a significant challenge for the effective treatment of hepatocellular carcinoma (HCC). The mechanism sorafenib remains unclear. Several microRNAs (miRNAs) have been identified as playing role in impairing sensitivity tumor cells to treatment. We examined behind miR-92b mediating HCC cells. detected that expression was significantly upregulated SOR-resistant HepG2/SOR compared parental HepG2/WT After transfection with inhibitor, proliferation remarkably...
Long noncoding RNAs (lncRNAs) have vital roles in the progression of colorectal cancer (CRC). Forkhead box P4-antisense RNA 1 (FOXP4-AS1) showed a potential unfavorable prognostic factor for CRC, while its underlying mechanism remains elusive. Thus, goal this research is to determine FOXP4-AS1 CRC occurrence and development. Herein, Dual-luciferase reporter assay was performed assess regulation miR-423-5p nucleus accumbens-associated protein (NACC1) activating transcription 3 (ATF3)...
Purpose: To isolate and identify the chemical components of Paraoncidium reevesii.Methods: Silica gel column chromatography was used to from petroleum ether ethyl acetate fractions acetone extract, structures compounds were derived 1H-nuclear magnetic resonance (1H-NMR), 13C-nuclear (13C-NMR) mass spectrometry (MS) analyses also with aid literature data for authenticated samples.Results: Cholesterol (1), baconipyrone D (2), chimyl alcohol (3), batyl (4), á-monpalmitin (5), stearic acid (6),...
Prealbumin is a serum protein which plays an important role in plasma transport of retinol and thyroxine. The accumulation variant prealbumin associated with hereditary disorder, familial amyloidotic polyneuropathy (FAP). In situ hybridization mouse gene cDNA probe was carried out fibroblasts. Analysis 114 R-banded metaphases showed that 13% the total grains were located on chromosome 4 46% this region C6-D1. Linkage syntenic group analysis (Ttr) between two groups 4, corresponded to present...
Gastric cancer (GC) is a globally common characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for diagnosis therapy. Long non-coding RNAs (lncRNAs) their downstream regulators are regarded to be implicated progression multiple types malignancies. Studies have shown that lncRNA small nucleolar RNA host gene 4 (SNHG4) serves as tumor promoter various malignancies, while its function has yet characterized. Therefore,...
Colorectal cancer is one of malignant tumors. microRNA plays an important role in various diseases. In this study, we evaluated miR-223's effect on the proliferation colon cells. Protein and RNA expression levels patients with clinical colorectal were determined by western blot real-time quantitative PCR respectively. addition, mechanism miR-223 action was explored combining transfection methods cell lines. Colon tissues showed significantly elevated compared adjacent tissues. Meanwhile,...
To explore expression changes and clinical significance of EBI3 in gastric cancer.