A5101672371- T-cell and Retrovirus Studies
- Acute Myeloid Leukemia Research
- Vector-Borne Animal Diseases
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Animal Disease Management and Epidemiology
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Cytokine Signaling Pathways and Interactions
- Platelet Disorders and Treatments
- Acute Ischemic Stroke Management
- Immunodeficiency and Autoimmune Disorders
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 and healthcare impacts
- Hepatitis C virus research
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Eosinophilic Disorders and Syndromes
Albert Einstein College of Medicine
2016-2025
Montefiore Medical Center
2016-2025
The Bronx Defenders
2024
University of Vermont
2024
Rainbow Children's Hospital
2021-2022
Yeshiva University
2019
Colchester Hospital
2012-2014
Baylor College of Medicine
2011-2013
The University of Texas Health Science Center at Houston
2013
University of California, Berkeley
2008
Background and Purpose— The safety of thrombolysis for acute stroke in patients with cancer is not well established. Our aim to study the outcomes after cancer. Methods— Patients ischemic who received were identified from 2009 2010 Nationwide Inpatient Sample. cancer-associated strokes noncancer compared based on demographics, comorbidities, outcomes. Results— Of 32 576 treated thrombolysis, had significantly higher comorbidity indices overall, but fewer vascular risk factors than strokes....
Eltrombopag stimulates multilineage hematopoiesis through intracellular iron chelation.
This report highlights a somewhat unique case of U2AF1 mutated myelodysplastic syndrome (MDS) with morphological evidence increased intramedullary erythrophagocytosis, in the absence obvious clinical signs hemolysis. These findings merit investigation larger cohort MDS cases to further delineate spectrum ineffective hematopoiesis and nonimmune hemolysis, including features distinctive S34 Q157 variants.
Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human lymphotropic virus type 1 that predominantly affects Japanese Caribbean populations. Most studies have focused on cohorts. We conducted retrospective analysis of 53 cases ATLL who presented to our institution between 2003-2014. in the population presents more often as acute lymphomatous subtypes, associated with complex cytogenetics, has high rate CNS involvement. The overall response first-line therapies...
Background Globally, 5 million to 10 people are infected with human T‐cell leukemia virus type 1, which causes adult leukemia/lymphoma (ATLL) in 2% 5% of the carriers. ATLL is a rare but extremely aggressive malignancy that can be challenging diagnose. Very little data exist on incidence patterns United States. Methods cases reported National Program Cancer Registries, Surveillance, Epidemiology, and End Results (SEER) program, New York State Registry were used for study. Age‐adjusted rates...
Adult T-cell leukemia/lymphoma (ATLL) remains challenging to treat and has dismal outcome. Allogeneic stem-cell transplantation (allo-SCT) promising results, but data remain scarce. In this single-center retrospective analysis of 100 patients with ATLL from north America (67 acute, 22 lymphomatous), 17 underwent allo-SCT 5 autologous SCT (ASCT), a median follow-up 65 months. Post-transplant 3-years relapse incidence (RI) non-relapse mortality (NRM) were 51% 37%, respectively, 3-year...
Progressive multifocal leukoencephalopathy (PML) is a life-threatening opportunistic infection of immunomodulatory therapies. PML cases reported in PubMed (1995–2017) following stem-cell transplantation (HSCT) or chemoimmunotherapy (CIT) for hematologic malignancies were reviewed. We found 107 cases, 40% HSCT recipients (32 allogeneic, 11 autologous) and indolent lymphomas receiving monoclonal antibodies (mAbs). had longer time to diagnosis (10.8 vs. 4 months, p < .001), higher proportion...
Importance Systematic data on the association between anticancer therapies and thromboembolic events (TEEs) in patients with COVID-19 are lacking. Objective To assess therapy exposure within 3 months prior to TEEs following diagnosis cancer. Design, Setting, Participants This registry-based retrospective cohort study included who were hospitalized had active cancer laboratory-confirmed SARS-CoV-2 infection. Data accrued from March 2020 December 2021 analyzed October 2022. Exposure Treatments...
Primary gastric chorioadenocarcinoma (PGC) is an exceedingly rare neoplasm which often misdiagnosed as adenocarcinoma at presentation. A markedly elevated serum beta human chorionic gonadotrophin (Beta HCG) level a characteristic feature of this tumor. 44 year old white male presented with generalized abdominal pain and fullness, tarry black stools weight loss 3 months duration. Medical work-up including imaging CT scans revealed the presence mass multiple liver metastases. Tumor markers...
3084 Background: The tumor suppressor p53 is mutated in approximately 50% of cancers. In those cancers with wild-type p53, its activity controlled by mouse double minute 2 (MDM2), an E3 ligase that tags for degradation. KT-253 a novel, highly potent heterobifunctional MDM2 degrader upregulates and overcomes the p53-MDM2 feedback loop, resulting >200-fold higher potency compared to inhibitors. preclinical PDX models sensitive WT solid tumors, AML ALL, robustly activates induces apoptosis,...
Abstract Hematopoietic stem cell (HSC) release is positively regulated by the sympathetic nervous system through β3 adrenergic receptor. Preclinical studies have demonstrated that combination of desipramine and G‐CSF resulted in improved HSC mobilization. Here, we present results an open‐label single‐arm pilot study patients with multiple myeloma undergoing autologous transplantation (ASCT) to assess safety efficacy combined G‐SCF induce The primary endpoint was including engraftment...
// Aditi Shastri 1 , Murali Janakiram Ioannis Mantzaris Yiting Yu 2 Jaime S. Londono Amit K. Verma and Stefan Barta 3 Division of Hematologic Malignancies, Department Oncology, Montefiore Medical Center & Albert Einstein College Medicine, Bronx, NY, USA Biostatistics, Fox Chase Cancer Center, Philadelphia, PA, Correspondence to: Shastri, email: ashastri@montefiore.org Keywords: follicular lymphoma, Surveillance, Epidemiology End Results database, prognosis, extranodal disease Received: March...
The MLL3 gene has been shown to be recurrently mutated in many malignancies including families with acute myeloid leukemia. We demonstrate that variant calls made by exome sequencing are false positives due misalignment homologous regions, a region on chr21, and can only validated long-range PCR. Numerous other genes reported COSMIC TCGA databases have pseudogenes cannot also conventional short read-based approaches. Genome-wide identification of pseudogene regions demonstrates frequency...
In the United States adult T cell lymphoma–leukemia (ATLL) carries a dismal prognosis and mainly affects immigrants from human lymphotropic virus 1 endemic areas. Allogeneic hematopoietic stem transplant (alloHSCT) can be effective is recommended as an upfront treatment in National Comprehensive Cancer Network guidelines. We studied barriers to alloHSCT one of largest ATLL populations States. chart donor registry reviews were conducted for 88 patients treated at Montefiore Medical Center...