A5005157556- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Genomics and Chromatin Dynamics
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Biochemical effects in animals
- Salmonella and Campylobacter epidemiology
- RNA Interference and Gene Delivery
- Trace Elements in Health
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Multiple Myeloma Research and Treatments
- Renal and related cancers
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- Nerve injury and regeneration
- Blood properties and coagulation
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
Albert Einstein College of Medicine
2012-2023
Montefiore Medical Center
2023
Yeshiva University
2014
Rutgers, The State University of New Jersey
2011
The tumor suppressor p53 is often inactivated via its interaction with endogenous inhibitors mouse double minute 4 homolog (MDM4 or MDMX) 2 (MDM2), which are frequently overexpressed in patients acute myeloid leukemia (AML) and other cancers. Pharmacological disruption of both these interactions has long been sought after as an attractive strategy to fully restore p53-dependent activity cancers wild-type p53. Selective targeting this pathway thus far limited MDM2-only small-molecule...
MicroRNAs (miRNAs) play important roles during development and also in adult organisms by regulating the expression of multiple target genes. Here, we studied function miR-133b zebrafish spinal cord regeneration show upregulation regenerating neurons brainstem after transection cord. has been shown to promote tissue other tissue, but its ability do so nervous system yet be tested. Inhibition antisense morpholino (MO) application resulted impaired locomotor recovery reduced axons from nucleus...
The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that already had low levels and further inhibited using either RNA interference or, to our knowledge, first-in-class small-molecule inhibitors of developed specifically allosterically interfere PU.1-chromatin binding through interaction the DNA minor groove flanks PU.1-binding motifs. These small molecules heterocyclic diamidine family disrupted target gene promoters led...
The surface molecule interleukin-1 receptor accessory protein (IL1RAP) is consistently overexpressed across multiple genetic subtypes of acute myeloid leukemia (AML) and other malignancies, including at the stem cell level, emerging as a novel therapeutic target. However, cell-intrinsic functions IL1RAP in AML cells are largely unknown. Here, we show that targeting via RNA interference, deletion, or antibodies inhibits pathogenesis vitro vivo, without perturbing healthy hematopoietic...
Eltrombopag stimulates multilineage hematopoiesis through intracellular iron chelation.
Despite the identification of several oncogenic driver mutations leading to constitutive JAK–STAT activation, cellular and molecular biology myeloproliferative neoplasms (MPN) remains incompletely understood. Recent discoveries have identified underlying disease-modifying aberrations contributing disease initiation progression. Here, we report that deletion Nol3 (Nucleolar protein 3) in mice leads an MPN resembling primary myelofibrosis (PMF). Nol3−/− harbor expanded Thy1+LSK stem cell...
Abstract Despite the established use of poly-chemotherapy, relapse continues to be most common cause death in AML and MDS cure rates remain below 20%. AML/MDS arise following accumulation stepwise genetic epigenetic changes hematopoietic stem progenitor cells (HSPC). Utilizing a novel strategy parallel transcriptional analysis sorted HSPC populations distinct subtypes AML, we compared gene expression with identical compartments from age-matched healthy controls identified Interleukin 1...
Abstract Previously, we described the CIITA-BX648577 gene fusion (Steidl C. et al., Nature 2011) was highly expressed in Hodgkin's Lymphoma cell line KM-H2. The Class II Transactivator (CIITA) has been to function regulation of immune responses and its deregulation may serve as a mechanism through which tumor cells evade immunosurveillance. In contrast, expression gene/protein encoded by novel locus BX648577/FLJ27352/C15orf65 is unknown. present study, report endogenous describe biological...