A5046897637- Muscle Physiology and Disorders
- RNA Research and Splicing
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Fish Ecology and Management Studies
- Genetic diversity and population structure
- Amyotrophic Lateral Sclerosis Research
- Aquatic Invertebrate Ecology and Behavior
- Mesenchymal stem cell research
- Genomics and Chromatin Dynamics
- Neurogenetic and Muscular Disorders Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Congenital Heart Disease Studies
- COVID-19 and healthcare impacts
- Genetics, Bioinformatics, and Biomedical Research
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Vascular anomalies and interventions
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- DNA Repair Mechanisms
- Cellular Mechanics and Interactions
University of Colorado Hospital
2025
University of Colorado Health
2025
University of Colorado Anschutz Medical Campus
2021-2025
University of Colorado Denver
2022-2025
University of Colorado System
2025
University of Colorado Boulder
2016-2022
Indiana University School of Medicine
2020
University of Inland Norway
2019-2020
Albert Einstein College of Medicine
2012-2015
Bucknell University
2014
Skeletal muscle stiffening after injury induces proliferation and activation of stem cells via YAP TAZ signaling.
Burn patients often require frequent moderate sedation for burn wound care procedures. The American Society of Anesthesiology recommends be made nil per os prior to sedation. Here, we aimed assess the risk in with uninterrupted nutrition. A 12-month single-center retrospective analysis on non-intubated/non-tracheostomy receiving was performed. total 97 sedations were completed 24 patients. median three oral premedications and intravenous analgesic/anxiolysis medications patient administered...
Abstract Introduction Friction burn depth is often variable, ranging from superficial to full thickness. The standard of care (SOC) for full-thickness friction burns includes autologous split-thickness skin grafts. However, the SOC deep partial-thickness or indeterminate less clear. Identifying optimal surgical treatment approach these wounds may help improve healing times and decrease wound needs patients. We therefore sought summarize our experience managing partial thickness burns....
The origin of species is a central topic in biology. Ecological speciation might be driver adaptive radiation, providing framework for understanding mechanisms, level, and rate diversification. Arctic charr
RNA-binding proteins (RBPs), essential for skeletal muscle regeneration, cause degeneration and neuromuscular disease when mutated. Why mutations in these ubiquitously expressed RBPs orchestrate complex tissue regeneration direct cell fate decisions remains poorly understood. Single-cell RNA-sequencing of regenerating Mus musculus reveals that RBP expression, including the expression many disease-associated RBPs, is temporally regulated stem cells correlates with specific stages myogenic...
Background Since the outset of coronavirus disease 2019 (COVID-19) pandemic, published tracheostomy guidelines have generally recommended deferral procedure beyond initial weeks intubation given high mortality as well concerns about transmission infection to providers. It is unclear whether in patients with COVID-19 facilitates ventilator weaning, and long-term outcomes are not yet reported literature. Methods This a retrospective study at single-center academic tertiary referral intensive...
We have developed and tested two linked but separable structured inquiry exercises using a set of Drosophila melanogaster GAL4 enhancer trap strains for an upper-level undergraduate laboratory methods course at Bucknell University. In the first, students learn to perform inverse PCR identify genomic location insertion, FlyBase flanking sequences primary literature synthesize current knowledge regarding nearest gene. second, we cross each strain UAS-CD8-GFP reporter strain, whole mount CNS...
ABSTRACT RNA-binding proteins (RBPs) are essential for skeletal muscle regeneration and RBP dysfunction causes degeneration neuromuscular disease. How ubiquitously expressed RBPs orchestrate complex tissue direct cell fate decisions in remains poorly understood. Single RNA-sequencing of regenerating reveals that expression, including numerous disease-associated RBPs, is temporally regulated stem cells correlates to stages myogenic differentiation. By combining machine learning with...
Abstract Background The origin of species is a central topic in biology aiming at understanding mechanisms, level and rate diversification. Ecological speciation an important driver adaptive radiation during post-glacial intra-lacustrine niche diversification fishes. Arctic charr Salvelinus alpinus L. complex the Northern hemisphere freshwater systems display huge morphological life history divergence lakes with one or several morphs present, thus offering unique opportunity to address...
Abstract Evolution of morphological traits is hypothesized to act on an extended time scale, yet studies have suggested that these changes are possible within a few generations. Trophic polymorphism enabled through niche adaptations and ecological opportunity one phenomenon facilitate occurrence rapid adaptive variation, common in many northern freshwater fish species. One such species Arctic charr, which known for its extensive variation morphology the morphs. However, speed at arises...