A5044020688- Connective Tissue Growth Factor Research
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA modifications and cancer
- Thyroid Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Kruppel-like factors research
- Erythrocyte Function and Pathophysiology
- Systemic Sclerosis and Related Diseases
- Chronic Myeloid Leukemia Treatments
- RNA Research and Splicing
- TGF-β signaling in diseases
- Periodontal Regeneration and Treatments
- Microtubule and mitosis dynamics
- Platelet Disorders and Treatments
- Vitamin D Research Studies
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Eosinophilic Disorders and Syndromes
Albert Einstein College of Medicine
2014-2024
Presbyterian Hospital
2024
NewYork–Presbyterian Hospital
2024
Cornell University
2024
Weill Cornell Medicine
2024
New York Hospital Queens
2024
John Jay College of Criminal Justice
2012-2015
City University of New York
2014-2015
Yeshiva University
2014-2015
Connective Tissue Growth Factor ( CCN2/CTGF ) and Nephroblastoma Overexpressed CCN3/NOV execute key functions within the hematopoietic compartment. Both are abundant in bone marrow stroma, which is a niche for hematopoiesis supports function. Roles 1,25‐dihydroxyvitamin D 3 (calcitriol) all‐trans retinoic acid have also been elucidated. Interestingly, some of annotated roles these vitamins overlap with established CCN2 CCN3. Yet, no factor has identified that unifies observations. In this...
Despite the identification of several oncogenic driver mutations leading to constitutive JAK–STAT activation, cellular and molecular biology myeloproliferative neoplasms (MPN) remains incompletely understood. Recent discoveries have identified underlying disease-modifying aberrations contributing disease initiation progression. Here, we report that deletion Nol3 (Nucleolar protein 3) in mice leads an MPN resembling primary myelofibrosis (PMF). Nol3−/− harbor expanded Thy1+LSK stem cell...
Cell surfaces display a wide array of molecules that confer identity. While flow cytometry and cluster differentiation (CD) markers have revolutionized cell characterization purification, functionally heterogeneous cellular subtypes remain unresolvable by the CD marker system alone. Using hematopoietic lineages as paradigm, we leverage extraordinary molecular diversity heparan sulfate (HS) glycans to establish “glycotypes” utilizing panel anti-HS single-chain variable fragment antibodies...
CCN2, also known as CTGF, the connective tissue growth factor, has recently been found to be in high abundance platelets and released upon activation, an effect inhibited by aspirin, suggesting additional role blood clotting and/or wound healing. It demonstrated that another member of CCN family, Nephroblastoma overexpressed gene (NOV, CCN3) functions hematopoietic potential, cell formation, helps maintain a competent immune system. Taken together, these two family members represent...
Connective Tissue Growth Factor (CTGF), an extracellular protein with key roles in wound healing and tissue homeostasis, has recently been shown to be abundance thrombocytes. Paradoxically, megakaryocytes, the platelet precursors bone marrow, contain no detectable levels of CTGF, source CTGF platelets is yet determined. It proposed that cells vicinity megakaryocyte secrete upon cellular signaling, at which point it then internalized by fragmenting entering vasculature. In this study, we...