Michelly Abreu
A5044748329- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- COVID-19 and healthcare impacts
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- Animal Disease Management and Epidemiology
- Vaccine Coverage and Hesitancy
- Vector-Borne Animal Diseases
- Biosimilars and Bioanalytical Methods
- COVID-19 Clinical Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Mining and Resource Management
- Graphene and Nanomaterials Applications
- Chronic Myeloid Leukemia Treatments
- Brain Tumor Detection and Classification
- Cutaneous lymphoproliferative disorders research
- Virus-based gene therapy research
- Natural Resources and Economic Development
- Nanowire Synthesis and Applications
- Clusterin in disease pathology
- Energy, Environment, Economic Growth
The University of Texas MD Anderson Cancer Center
2023-2024
Montefiore Medical Center
2020-2023
Albert Einstein College of Medicine
2020-2023
Michelin (United States)
2023
Brazilian Institute of Environment and Renewable Natural Resources
2022
The Bronx Defenders
2020
Hospital de Santa Maria
2016
Abstract Axicabtagene ciloleucel (Axi-cel) is a CD-19 Chimeric Antigen Receptor T cell therapy approved for the treatment of relapsed/refractory diffuse large B lymphoma. We treated ten patients with DLBCL post-FDA approval in an inner-city tertiary center Bronx. Eight (80%) had received ≥ 3 lines therapy, six prior radiation, and seven recurrent disease after autologous hematopoietic stem transplant (AHCT). Our cohort included one patient HIV, two hepatitis B, CNS involvement Axi-cel led to...
In this paper we analyze the role of governance quality on environmental policy in Brazil regarding natural resources exploration, particularly oil. Governance is reflected five indicators following approach World Bank: political stability, regulatory quality, government effectiveness, rule law, and control corruption. We highlight main challenges faced by country which can hinder policy, when they influence oil exploration. The first problem detected interference management. As governments...
Adult T-cell leukemia/lymphoma (ATLL) remains challenging to treat and has dismal outcome. Allogeneic stem-cell transplantation (allo-SCT) promising results, but data remain scarce. In this single-center retrospective analysis of 100 patients with ATLL from north America (67 acute, 22 lymphomatous), 17 underwent allo-SCT 5 autologous SCT (ASCT), a median follow-up 65 months. Post-transplant 3-years relapse incidence (RI) non-relapse mortality (NRM) were 51% 37%, respectively, 3-year...
Adoptive immunotherapy using CD19-targeted Chimeric antigen receptor T cells (CAR-T) has revolutionized the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Data is limited on propensity infections and lymphohematopoietic reconstitution after Day 30 (D30) following CAR-T cell therapy. In this study, we evaluated prevalence nature infectious complications in an expanded cohort DLBCL patients treated with CD19 therapy its association dynamics leukocyte subpopulation...
Abstract It is well established that COVID-19 carries a higher risk of morbidity and mortality in patients with hematologic malignancies, however, very little data on ethnicity specific responses this particular patient population currently exist. We program rapid vaccination evaluation antibody-mediated response to all EUA vaccines an inner city minority determine the factors contribute poor seroconversion population. conducted cross-sectional cohort study 126 malignancies outpatient...
Chimeric antigen receptor (CAR) T-cell therapy is an innovative immunotherapy treatment for hematological malignancies. Some of the challenges in using this are development cytokine release syndrome, immune effector cell-associated neurotoxicity immunosuppression, and hypogammaglobulinemia, which can be prolonged significantly increase patients' risk infection. Cytomegalovirus (CMV) well known to cause disease organ damage immunocompromised hosts, increasing mortality morbidity. We present a...
Autologous stem cell transplantation in an older adult populationOver the past decade there has been a remarkable progress treatment of multiple myeloma (MM) and non-Hodgkin lymphoma (NHL).Nevertheless, autologous transplant (ASCT) remains integral part care for patients with MM, one few curative options relapsed/refractory (R/R) NHL.Historically, arbitrary age 65 used to determine patient's eligibility ASCT.This stems from fact that majority prospective studies evaluating efficacy ASCT MM...