A5066224258- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Autoimmune and Inflammatory Disorders Research
- Virus-based gene therapy research
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Cancer-related cognitive impairment studies
- Marine Invertebrate Physiology and Ecology
- Venomous Animal Envenomation and Studies
- Silicon Carbide Semiconductor Technologies
- Cancer Immunotherapy and Biomarkers
- CNS Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Advancements in Semiconductor Devices and Circuit Design
- Rabies epidemiology and control
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Treatments and Studies
- Boron Compounds in Chemistry
- Lung Cancer Treatments and Mutations
- Biomedical Ethics and Regulation
- Immunodeficiency and Autoimmune Disorders
- Protein Degradation and Inhibitors
- Biosimilars and Bioanalytical Methods
The University of Texas MD Anderson Cancer Center
2021-2024
Stanford University
2021
Abstract About 70% of patients with large B-cell lymphoma (LBCL) who are treated axicabtagene ciloleucel (axi-cel) and achieve a partial response (PR) or stable disease (SD) on the day 30 (D30) positron emission tomography (PET)–computed (CT) scan progress; however, factors that predictive progression unknown. This retrospective study LBCL were axi-cel at MD Anderson Cancer Center between January 2018 February 2021. Among 50 D30 PR/SD, 13 (26%) converted to complete (CR). 95 CR, 72 (76%)...
A man in his 70s with metastatic colorectal cancer presented worsening clinical symptoms and imaging studies concerning for disease progression. He had received two cycles of pembrolizumab, but due to symptomatic presentation significant decline performance status, there was concern disease. Transitioning hospice briefly considered, given the notable increase tumour size. Despite presence radiographic findings, pseudoprogression—defined as an size(s) and/or visual appearance new lesion(s),...
B7-H3 (CD276), a member of the B7-family immune checkpoint proteins, has been shown to have immunological and non-immunological effects promoting tumorigenesis [1, 2] expression correlates with poor prognosis for many solid tumors, including cervical, ovarian breast cancers [3-6]. We recently identified tumor-cell autochthonous tumorigenic role dimerization 4Ig isoform (4Ig-B7-H3) [7], where 4Ig-B7-H3 in cis activated tumor-intrinsic cellular proliferation pathways, providing novel...
Complications occurring after lymphodepleting chemotherapy (LDC) may delay chimeric antigen receptor (CAR) T-cell infusion. The effect of these delays on clinical outcomes is unclear. We performed a retrospective analysis 240 patients with relapsed/refractory large B-cell lymphoma treated standard-of-care axicabtagene ciloleucel (axi-cel) and identified 40 (16.7%) who had in axi-cel Of these, 85% due to infection. At time LDC initiation, delayed infusion lower absolute neutrophil count...
Cardiac injury is infrequently described as a complication of snake bite envenomation. We present the case 62-year-old male with shortness breath, right lower extremity edema, and elevated cardiac troponin 6 days after Northern Pacific rattlesnake bite.