A5100455424- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Luminescence and Fluorescent Materials
- Hearing, Cochlea, Tinnitus, Genetics
- Enhanced Recovery After Surgery
- Music Therapy and Health
- Cerebral Palsy and Movement Disorders
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Reactions
- Cold Atom Physics and Bose-Einstein Condensates
- Parkinson's Disease Mechanisms and Treatments
- Asymmetric Hydrogenation and Catalysis
- Supramolecular Chemistry and Complexes
- Lung Cancer Treatments and Mutations
- Autophagy in Disease and Therapy
- Body Composition Measurement Techniques
- Calcium signaling and nucleotide metabolism
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Antioxidant Activities
- interferon and immune responses
- Advanced Frequency and Time Standards
Shandong Provincial Hospital
2020-2025
Shandong First Medical University
2021-2025
University of South China
2025
Peking University First Hospital
2025
Peking University
2020-2025
University of Chinese Academy of Sciences
2024
Chinese Academy of Sciences
2024
Shandong Tumor Hospital
2024
Shanghai Institute of Materia Medica
2024
Nanjing Medical University
2019-2023
Introduction Cochlear spiral ganglion neurons (SGNs) could be damaged by ototoxic drug, cisplatin (Cis), during which process autophagy was involved. FAM134B, the first detected endoplasmic reticulum (ER-phagy) receptor, plays an important part in dynamic remodelling of ER, mutation affects sensory and autonomic neurons. However whether FAM134B-mediated ER-phagy involved Cis-induced SGN damage or not unknown. The present study designed to determine FAM134B is expressed SGNs C57BL/6 mice and,...
The bis(silylene)-based SiC(sp3)Si pincer ligand N,N′-bis(LSi:)dipyrromethane [SiCH2Si] (L1; L = PhC(NtBu)2) with a C(sp3) atom anchor was synthesized, and its coordination chemistry to iron studied. Two novel hydride complexes, [SiCHSi]Fe(H)(N2)(PMe3) (1) [SiCHSi]Fe(H)(PMe3)2 (2), were synthesized in the reaction of L1 Fe(PMe3)4 via C(sp3)–H bond activation under different inert atmospheres (N2 argon). To best our knowledge, 1 2 are first examples hydrido complex produced through bond. At...
Abstract Ginkgo biloba extract is reported to have therapeutic effects on aging‐related disorders. However, the specific component responsible for this biological function and its mechanism of action remain largely unknown. This study finds that Ginkgetin, an active ingredient extract, can alleviate cellular senescence improve pathologies in multiple tissues aging mice. To reveal molecular Ginkgetin's anti‐aging effect, a graph convolutional network‐based drug “on‐target” pathway prediction...
Colorectal cancer (CRC) ranks among the highest in incidence and mortality rates globally. A significant portion of cases deaths can be attributed to modifiable risk factors, with smoking, alcohol use, high body mass index (BMI) being three most prominent. However, impact these factors on across regions, genders, age groups remains insufficiently characterized. Utilizing data from Global Burden Disease (GBD) study 2019, restrictive cubic splines (RCS) quantile regression analyses are applied...
Two novel cyclodextrin derivatives were synthesized that could self-assemble into a supramolecular polymer and gel in different solvent environments. Importantly, the obtained self-assemblies, including vesicles, micro-fibers gels, respond to various external stimuli efficiently.
The self-assembly of an aromatic amino acid affords diverse aggregates from flat nanofibers to twist with tunable supramolecular chirality.
This paper reports an interesting type of self-assembly systems based on dynamic covalent bonds. The are pH-responsible and reversible, which could be utilized for controlling the morphology transformation assemblies. In alkaline conditions, amine group 11-aminoundecanoic acid (AUA) can connect with aldehyde benzaldehyde (BA) or 1-naphthaledhyde (NA) by bond to form a small organic building block accompanied morphological from vesicles fibers. When pH is lowered neutral value, bonds (imine...
An air-stable N-heterocyclic PSiP pincer iron hydride FeH(PMe3)2(SiPh(NCH2PPh2)2C6H4) (4) was synthesized by Si–H activation of a Ph-substituted [PSiP] ligand. The analogous strong electron-donating iPr-substituted ligand prepared and introduced into complex to give an nitrogen FeH(N2)(PMe3)(SiPh(NCH2PiPr2)2C6H4) (6). Both 4 6 showed similar high efficiency for catalytic dehydration primary amides nitriles. Air-stable the best catalyst its stabilization convenient preparation. A diverse...
The therapeutic effect of dihydroartemisinin (DHA) against cutaneous squamous cell carcinoma (cSCC) has been previously demonstrated; however, the underlying mechanism remains unclear. This study sought to verify DHA cSCC and explore its in A431 cells. reported that inhibited cells proliferation a time- concentration-dependent manner promoted apoptosis. Moreover, invasion migration Mechanistically, autophagy activation absent melanoma 2 (AIM2) inflammasome pathway NF-κB/HIF-1α/VEGF pathway....
The molecular mechanisms that regulate the proliferation and differentiation of inner ear spiral ganglion cells (SGCs) remain largely unknown. Shikonin (a naphthoquinone pigment isolated from traditional Chinese herbal medicine comfrey root) has anti-oxidation, anti-apoptosis promoting effects on neural progenitor cells. To study protective effect shikonin auditory nerve damage, we neuron (SGNs) Schwann (SGSs) provide nutrients in vitro pretreated them with shikonin. We found can reduce...
As the most frequent fungal pathogen in humans, Candida albicans can develop serious drug resistance because its biofilms are resistant to antifungal agents; this leads an urgent need novel antifungals. Here, we evaluated efficacy of antithrombotic drug, suloctidil, against C. vitro and vivo. We found that suloctidil is effective inhibit biofilm, with a minimum inhibitory concentration (MIC80) 4 μg/mL, biofilm inhibiting (BIC80) 16 μg/mL eradicating (BEC80) 64 μg/mL. Furthermore,...
The dehydration of primary amides to their corresponding nitriles using four [PSiP]‐pincer hydrido iron complexes 1–4 [(2‐Ph 2 PC 6 H 4 ) MeSiFe(H)(PMe 3 ( 1 ), (2‐Ph HSiFe(H)(PMe (2‐(iPr) and )] as catalysts in the presence (EtO) SiH dehydrating reagent was explored good excellent yields. It proved for first time that Lewis acid could significantly promote this catalytic system under milder reaction conditions than other acid‐promoted system, such shorter or lower temperature. This is also...
Vesicles with dynamic membranes provide an ideal model system for investigating biological membrane activities, whereby vesicle aggregation behaviors including adhesion, fusion, fission, and contraction/extension have attracted much attention. In this work we utilize aromatic amino acid (pyrene-appended glutamic acid, PGlu) to prepare nanovesicles that aggregate form clusters selectively induced by Fe3+ or Cu2+, the vesicles transform into irregular nano-objects when interacting Al3+....
Background The primary motor cortex (M1) is an important hub in the circuitry of Parkinson’s disease (PD), but subregions’ function and their correlation to tremor dominant (TD) postural instability gait disturbance (PIGD) with PD remain unclear. This study aimed determine whether functional connectivity (FC) M1 subregions varied between PIGD subtypes. Methods We recruited 28 TD patients, 49 42 healthy controls (HCs). was divided into 12 regions interest using Human Brainnetome Atlas...
Cyanostilbene modified with dimethylaniline (CMD) could self-assemble into vesicles and fibrous morphologies depending on the solvophobic properties. Furthermore, morphology of well-defined nanostructures be changed enhanced emission triggered by photo-isomerization cyanostilbene. The present system has potential for building luminescent color conversion materials.
Macrophages are recognized as vital players in renal fibrosis, with a high degree of heterogeneity and plasticity, the triggering receptor expressed on myeloid cell-2 (TREM-2) is highly macrophages participates progression tissue fibrosis. However, mechanism by which TREM-2 mediates fibrosis still unclear. Our study revealed that exosomes derived from TREM-2-deficient (TREM-2