A5100443117- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- Heat shock proteins research
- Intraocular Surgery and Lenses
- Adipose Tissue and Metabolism
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- RNA regulation and disease
- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Sirtuins and Resveratrol in Medicine
- Fungal and yeast genetics research
Qilu Hospital of Shandong University
2017-2025
Hebei University
2025
Fudan University Shanghai Cancer Center
2019-2025
Shanghai Medical College of Fudan University
2022-2025
University of Liverpool
2013-2025
Nanjing Drum Tower Hospital
2017-2024
Zhengzhou University
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Southern Medical University
2009-2024
Guangdong Medical College
2022-2023
Tamoxifen is the most commonly used endocrine therapy for patients with hormone receptor (HR)-positive breast cancer. Despite its initial therapeutic efficacy, many eventually develop drug resistance, which remains a serious clinical challenge. To investigate roles of circular RNAs (circRNAs) in tamoxifen tamoxifen-resistant MCF-7 cell line was established and screened circRNA expression profile by RNA sequencing. hsa_circ_0025202, that significantly downregulated, selected further...
Abstract Background Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed various cancers. However, the functional of lncRNAs breast cancer remain largely unknown. Methods Based on public databases integrating bioinformatics analyses, overexpression lncRNA BCRT1 tissues was detected further validated a cohort tissues. The effects proliferation, migration, invasion macrophage polarization were determined by vitro vivo experiments. Luciferase...
The tumor microenvironment contributes to progression and metastasis. Cancer-associated fibroblasts (CAFs) form a major cellular component of the microenvironment. In this study, we further explored mechanisms underlying tumor-promoting roles CAFs. Methods: Patient-derived CAFs normal (NFs) were isolated from breast carcinomas adjacent tissue. Exosomes by ultracentrifugation CAF-derived exosomal microRNAs screened using next-generation sequencing technology. MiR-500a-5p expression was...
The protein-coding ability of circular RNAs (circRNAs) has recently been a hot topic, but the expression and roles circRNAs in triple-negative breast cancer (TNBC) remain uncertain. By intersecting circRNA sequencing data from clinical samples cell lines, we identified circRNA, termed circ-EIF6, which predicted poorer prognosis correlated with clinicopathological characteristics cohort TNBC patients. Functionally, showed that circ-EIF6 promoted proliferation metastasis cells vitro vivo....
Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. CircRNAs are expected to be potential diagnostic biomarkers therapeutic targets for variety malignancies. However, the functions underlying mechanisms circRNAs in triple-negative breast cancer (TNBC) largely unknown.
Chemoresistance is one of the major causes therapeutic failure and poor prognosis for breast cancer patients, especially triple-negative patients. However, underlying mechanism remains elusive. Here, we identified novel functional roles heat shock protein beta-1 (HSPB1), regulating chemoresistance ferroptotic cell death in cancer. Based on TCGA GEO databases, HSPB1 expression was upregulated tissues associated with which considered an independent prognostic factor Functional assays revealed...
Adipose tissue expansion during obesity is associated with increased macrophage infiltration. Macrophage-derived factors significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. Identification of the major that mediate detrimental effects macrophages on adipocytes may offer potential therapeutic targets. IL-1β, a proinflammatory cytokine, suggested to be involved in development resistance. This study investigated role IL-1β...
Abstract Triple-negative breast cancer (TNBC) is highly heterogeneous and has a poor prognosis. It therefore important to identify the underlying molecular mechanisms in order develop novel therapeutic strategies. Although emerging research revealed long noncoding RNAs (lncRNA) as vital carcinogenesis progression, their functional involvement TNBC not been well defined. In this study, we utilized The Cancer Genome Atlas (TCGA) database analyzed clinical samples show that antisense transcript...
Recently, long noncoding RNAs (lncRNAs) have become the key gene regulators and prognostic biomarkers in various cancers. Through microarray data, Linc00339 was identified as a candidate oncogenic lncRNA. We compared expression levels of several breast cancer cell lines normal mammary gland epithelial line. The effects on tumor progression were examined both vitro vivo. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays applied to evaluate functions Linc00339, miR-377-3p,...
Abstract Background Lung adenocarcinoma (LUAD) is the leading cause of death worldwide. However, roles long noncoding RNAs (lncRNAs) hijacked by super-enhancers (SEs), vital regulatory elements epigenome, remain elusive in progression LUAD metastasis. Methods SE-associated lncRNA microarrays were used to identify dysregulated lncRNAs LUAD. ChIP-seq, Hi-C data analysis, and luciferase reporter assays utilized confirm hijacking LINC01977 SE. The functions mechanisms explored a series vitro...
Mitophagy, which selectively eliminates the dysfunctional and excess mitochondria by autophagy, is crucial for cellular homeostasis under stresses such as hypoxia. Dysregulation of mitophagy has been increasingly linked to many disorders including neurodegenerative disease cancer. Triple-negative breast cancer (TNBC), a highly aggressive subtype, reported be characterized However, role in hypoxic TNBC well underlying molecular mechanism largely unexplored. Here, we identified GPCPD1...
Abstract Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of that suggested to be associated with hypoxia. This study the first identify novel circular RNA (circRNA), circTBC1D14, whose expression significantly upregulated in TNBC. The authors confirm high circTBC1D14 poor prognosis patients cancer. circTBC1D14‐associated mass spectrometry and RNA‐binding protein‐related bioinformatics strategies indicate FUS can interact which bind downstream flanking sequence induce...
Abstract Breast cancer is the major common malignancy worldwide among women. Previous studies reported that cancer-associated fibroblasts (CAFs) showed pivotal roles in regulating tumor progression via exosome-mediated cellular communication. However, detailed mechanism underlying exosomal circRNA from CAFs breast remains ambiguous. Here, profiling of cancer-derived and normal (NFs) was detected by high-throughput sequencing, upregulated circTBPL1 expression identified CAF exosomes. The...
Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in a number of biological processes; however, further study is still warranted to comprehensively reveal their functions. In this study, we showed the lncRNA non-homologous end joining (NHEJ) pathway 1 (LINP1) was related breast cancer cell proliferation, metastasis and chemoresistance. Loss- gain-of function were used assess role LINP1 promoting progression. knockdown mitigated growth by inducing G1-phase cycle...
Emerging evidence suggests that circular RNAs (circRNAs) have crucial roles in various processes, including cancer development and progression. However, the functional of circRNAs breast remain to be elucidated. In this study, we identified a novel circRNA (named circBMPR2) whose expression was lower tissues with metastasis. Moreover, circBMPR2 negatively associated motility cells significantly downregulated human tissues. Functionally, found knockdown effectively enhanced cell...
Metastasis is a core hallmark of cancer that leads to high mortality patients, especially in hepatocellular carcinoma (HCC). However, the underlying mechanisms long noncoding RNAs (lncRNAs) HCC metastasis remain largely unknown. We found ID2-AS1 expression decreased metastatic cell lines and tissues, lower predicted reduced overall survival patients. significantly suppressed migration, invasion cells vitro vivo. Mechanistically, regulated transcription its adjacent gene inhibitor DNA binding...
Abstract Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in cancerous processes as either oncogenes or tumor suppressor genes. Here, we demonstrated lncRNA-PRLB (progression-associated lncRNA breast cancer) was upregulated human cancer tissues and cell lines. Further evaluation verified positively correlated with the extent of metastasis, its expression shorter survival time patients. We identified microRNA miR-4766-5p an inhibitory target...
Circular RNA (circRNA), as a kind of novel identified non-coding RNA, has become the focus attention for its vital physiological and pathological roles. However, function mechanism circRNAs in regulation cancer progression are largely unknown. In present study we found circRNA termed circHMCU whose expression was associated with poor prognosis. It upregulated cell lines high metastatic potential compared parental line breast tissues normal tissues. vitro results proved that could...