A5100460913- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- GDF15 and Related Biomarkers
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- MXene and MAX Phase Materials
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Renal and related cancers
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- AI in cancer detection
- Immune Cell Function and Interaction
- biodegradable polymer synthesis and properties
- Nuclear Receptors and Signaling
- Chemistry and Chemical Engineering
- Galectins and Cancer Biology
- Bone Metabolism and Diseases
- RNA regulation and disease
- Lignin and Wood Chemistry
- Atmospheric aerosols and clouds
Second Affiliated Hospital of Nanjing Medical University
2009-2025
Jiangsu Cancer Hospital
2020-2025
Nanjing Medical University
2015-2025
Sichuan Agricultural University
2025
Jiangsu Province Hospital
2020-2024
Tianjin Hospital
2023
Weifang Medical University
2023
Shaanxi University of Technology
2023
Zhengzhou Central Hospital
2023
Ningbo University
2023
Abstract Circular RNAs (circRNA) are a class of covalently closed single-stranded that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated non-small cell lung (NSCLC) tissues, and negatively correlate with NSCLC malignant features. Elevated inhibits growth metastasis cells. Mechanistically, functions as scaffold enhance the interaction between TRIM25 IGF2BPs, positive regulator tumor progression metastasis. This TRIM25/circNDUFB2/IGF2BPs ternary...
Abstract Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role circRNA lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore expression profiles and mRNA 5 paired samples LUSC. By analyzing co-expression network differentially expressed circRNAs dysregulated mRNAs, identify that cycle-related circRNA, circTP63 , is upregulated LUSC tissues its upregulation correlated with larger tumor size higher TNM stage patients....
Abstract Background Emerging evidence indicates that circular RNAs (circRNAs) and m 6 A RNA methylation participate in the pathogenesis metastasis of multiple malignancies including hepatocellular carcinoma (HCC). However, it remains undocumented how circRNAs form a feedback loop with modification contributing to HCC. Methods novel hsa_circ_0017114 (circGPR137B) was identified from three pairs primary HCC adjacent normal tissues by circRNA expression profiling. The association circGPR137B...
Abstract Background Aberrant expression of circular RNAs (circRNAs) contributes to the initiation and progression human malignancies, but underlying mechanisms remain largely elusive. Methods High-throughput sequencing was performed screen aberrantly expressed circRNAs or miRNAs in colorectal cancer (CRC) adjacent normal tissues. A series gain- loss-of-function studies were conducted evaluate biological behaviors CRC cells. RNA pulldown, mass spectrometry, RIP, qRT-PCR, Western blot,...
Aberrant expression of circular RNAs (circRNAs) is involved in cancer progression through interaction with RNA-binding proteins (RBPs). Herein, we screened circRNA A549 cells circBase and the crosslinking immunoprecipitation (CLIP) data human antigen R (HuR), an extensively studied RBP, identified a circRNA, circ-defective cullin neddylation 1 domain containing 4 (circDCUN1D4), originating from DCUN1D4 gene transcript. circDCUN1D4 downregulated tumor samples under mediation DExH-box helicase...
Abstract Background Lung adenocarcinoma (LUAD) is the leading cause of death worldwide. However, roles long noncoding RNAs (lncRNAs) hijacked by super-enhancers (SEs), vital regulatory elements epigenome, remain elusive in progression LUAD metastasis. Methods SE-associated lncRNA microarrays were used to identify dysregulated lncRNAs LUAD. ChIP-seq, Hi-C data analysis, and luciferase reporter assays utilized confirm hijacking LINC01977 SE. The functions mechanisms explored a series vitro...
Accumulating studies have implicated that circular RNAs (circRNAs) play vital roles in the pathogenesis of rheumatoid arthritis (RA). Dysregulation macrophage polarization leads to immune homeostatic imbalance RA. However, altering effects and mechanisms circRNAs on macrophages balance remain largely unclear. We aimed investigate potential role circRNA_17725 The high-throughput sequence was performed identify dysregulated confirmed data by CCK-8, EdU, Annexin V/PI staining elucidate...
Abstract The present study aimed to determine whether apelin-13 could attenuate cardiac fibrosis via inhibiting the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway inhibit reactive oxygen species in heart failure (HF) rats. HF models were established by inducing ischemia myocardial infarction (MI) through ligation of left anterior descending artery Sprague–Dawley (SD) MI-induced changes hemodynamics and function reversed administration. increases levels collagen I, III,...
Abstract Background Biological role and clinical significance of circular RNAs (circRNAs) remain largely unknown. Herein, we aimed to investigate biological function, molecular mechanism, a RNA FOXM1 (circFOXM1) in non-small cell lung cancer (NSCLC). Methods Expression circFOXM1 was measured 48 paired samples NSCLC by qRT-PCR. Functional roles on tumor cells were explored vitro vivo assays. Transcriptome sequencing employed screen the molecules involved regulatory network....
<p>5. cEMSY promotes ICD-driven anti-tumor immune surveillance.</p>
<p>Supplementary Fig. 3. cEMSY induces ICD in vitro.</p>
<div>Abstract<p>Immunogenic cell death (ICD) induces an active immune response. Activating ICD represents a potential approach to boost the antitumor activity of immunotherapy, highlighting need identify effective and safe inducers. In this study, we identified conserved, ICD-related circular RNA cEMSY by systematically screening models induced multiple stressors in lung adenocarcinoma. triggered adenocarcinoma cells both <i>in vitro</i> vivo</i>, leading...
<p>Supplementary Fig. 11. cEMSY expression level affects patient prognosis in multiple clinical cancer cohorts.</p>
<p>Supplementary Fig. 4. cEMSY knockout abrogates the ability of cellular stressors to induce ICD.</p>
<p>Supplementary Fig. 2. Characteristics of cEMSY circRNA and expression profiles in LUAD.</p>
<p>Supplementary Fig. 6. In vitro and in vivo characterization of designed circRNA.</p>
<p>Supplementary Fig. 9. mtDNA mediates the activation of ICD induced by cEMSY in vivo.</p>
<p>Supplementary Fig. 8. cEMSY activates antiviral immune signaling.</p>
<p>Supplementary Fig. 7. In vitro-transcribed cEMSY combined with anti-PD-1 promotes antitumor cure.</p>
<p>Table S1-S5</p>
<p>Supplementary Fig. 10. cEMSY modulates immune responses through facilitating the translocation of TDP-43 into mitochondria.</p>
<p>Supplementary Fig. 1. Filter ICD related circRNAs.</p>