A5115604981- Circular RNAs in diseases
- MXene and MAX Phase Materials
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Cardiac electrophysiology and arrhythmias
- Organ Transplantation Techniques and Outcomes
- Genetic Neurodegenerative Diseases
- Immunotherapy and Immune Responses
- Cardiac Arrhythmias and Treatments
- Wound Healing and Treatments
- Ion channel regulation and function
- Reconstructive Surgery and Microvascular Techniques
- Superconductivity in MgB2 and Alloys
- Periodontal Regeneration and Treatments
- Adenosine and Purinergic Signaling
- interferon and immune responses
- Mesenchymal stem cell research
- Bioinformatics and Genomic Networks
- Cardiovascular Function and Risk Factors
Jiangsu Cancer Hospital
2023-2024
Affiliated Hospital of North Sichuan Medical College
2023
Chinese PLA General Hospital
2023
Zunyi Medical University
2023
Binzhou University
2016-2023
Binzhou Medical University
2016-2023
Sun Yat-sen University
2023
Sichuan University
2023
University of Hong Kong
2023
Southern Medical University
2023
<p>5. cEMSY promotes ICD-driven anti-tumor immune surveillance.</p>
<p>Supplementary Fig. 3. cEMSY induces ICD in vitro.</p>
<div>Abstract<p>Immunogenic cell death (ICD) induces an active immune response. Activating ICD represents a potential approach to boost the antitumor activity of immunotherapy, highlighting need identify effective and safe inducers. In this study, we identified conserved, ICD-related circular RNA cEMSY by systematically screening models induced multiple stressors in lung adenocarcinoma. triggered adenocarcinoma cells both <i>in vitro</i> vivo</i>, leading...
<p>Supplementary Fig. 11. cEMSY expression level affects patient prognosis in multiple clinical cancer cohorts.</p>
<p>Supplementary Fig. 4. cEMSY knockout abrogates the ability of cellular stressors to induce ICD.</p>
<p>Supplementary Fig. 2. Characteristics of cEMSY circRNA and expression profiles in LUAD.</p>
<p>Supplementary Fig. 6. In vitro and in vivo characterization of designed circRNA.</p>
<p>Supplementary Fig. 9. mtDNA mediates the activation of ICD induced by cEMSY in vivo.</p>
<p>Supplementary Fig. 8. cEMSY activates antiviral immune signaling.</p>
<p>Supplementary Fig. 7. In vitro-transcribed cEMSY combined with anti-PD-1 promotes antitumor cure.</p>
<p>Table S1-S5</p>
<p>Supplementary Fig. 10. cEMSY modulates immune responses through facilitating the translocation of TDP-43 into mitochondria.</p>
<p>Supplementary Fig. 1. Filter ICD related circRNAs.</p>
To study the role of miR-138 on repair diabetic foot ulcer (DFU) and further to explore its possible mechanism.miR-138 inhibitor, IGF-1, LY294002 were used in DFU rat mode, mRNA expression was detected. HE staining observe histological changes skin rats. The level inflammation, wound healing, blood vessel formation-related factors detected by ELISA immunohistochemical. VEGF PI3K/AKT pathway-related proteins Western blot. determine underlying mechanism DFU, telomerase inhibitor BIBR-1232...
Abstract Immunogenic cell death (ICD) induces an active immune response. Activating ICD represents a potential approach to boost the anti-tumor activity of immunotherapy, highlighting need identify effective and safe inducers. In this study, we identified conserved, ICD-related circular RNA cEMSY by systematically screening models induced multiple stressors in lung adenocarcinoma (LUAD). triggered LUAD both vitro vivo, leading release damage-associated molecular patterns promoting T...
Abstract Background Chronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after transplantation (LTx), but effective and safe drugs are not available. Metformin exhibits high therapeutic potential due to its antifibrotic immunomodulatory effects; however, it is unclear whether metformin exerts a effect in CLAD. We sought investigate the of on CLAD based rat models. Methods Allogeneic LTx rats were treated with Cyclosporin A (CsA) first week, followed by...
Objective To investigate the methods of repair lateral skin and soft tissue defect middle rear foot with plantar medial flap transferred before achilles tendon. Methods Fifteen cases were repaired pedicled posterior tibia artery tendon from January, 2012 to October, 2015. All 15 patients followed up in way by telephone or back hospital postoperatively 3 months years, including 6 follow-up 9 back-to-hospital follow-up, observe appearance, functions whether survived...
Background: While the evidence from large-scale randomized controlled trials is conflicting, there a paucity of genetic cardiovascular adverse effects sclerostin (SOST) inhibition.Method: We performed pairwise statistical analyses to estimate pleiotropy between circulating SOST and heel bone mineral density (eBMD) as well diseases (CVDs). Additionally, we integrated genetic, transcriptional, proteomic data explore causal relationship proxied inhibition eBMD CVDs risk evaluate therapeutical...