Objective: The aims of this study were to compare the characteristics three motor subtype classifications in patients with de novo Parkinson's disease (PD) and find most suitable classification for identifying non-motor symptoms (NMSs). Methods: According previous studies, a total 256 PD classified using tremor-dominant/mixed/akinetic-rigid (TD/mixed/AR), TD/indeterminate/postural instability gait disturbance (PIGD), predominantly TD/predominantly PIGD (p-TD/p-PIGD) systems. Results: Among...

Presently, neurotransmitter deficits in GBA-related Parkinson's disease (GBA-PD) and relationships with cognitive impairment are poorly understood. A better understanding of impairments GBA-PD - particularly the newly diagnosed drug-naïve phase may support developing targeted intervention strategies. We aimed to investigate patterns idiopathic PD (iPD) performance correlations.We recruited 189 patients for GBA sequencing. Voxel-wise gray matter volume (GMV) was evaluated a subgroup 17...

Differences in cortical morphology have been reported individuals with Parkinson's disease (PD). However, the pathophysiological mechanism of transcriptomic vulnerability local brain regions remains unclear.

Parkinson's disease (PD) is characterized by olfactory dysfunction (OD) and cognitive deficits at its early stages, yet the link between OD also not well-understood. This study aims to examine changes in network associated with their relationship function de novo PD patients. A total of 116 drug-naïve patients 51 healthy controls (HCs) were recruited for this study. Graph theoretical approaches employed reveal abnormalities topological characteristics network. Network-based statistics (NBS)...

ABSTRACT Background The high heterogeneity of Parkinson's disease (PD) hinders personalized interventions. Brain structure reflects damage and neuroplasticity is one the biological bases symptomatology. Subtyping PD in framework brain helps prediction trajectories optimizes treatment strategies. Methods study included a total 283 de novo 141 healthy controls (HC). Structural between HC was compared, patients were classified using Heterogeneity through Discriminative Analysis. Gray matter...

Circulating microRNAs (miRNAs) have been proposed to be accessible biomarkers for Parkinson's disease (PD). However, there is a lack of known miRNAs that can serve as prodromal PD (pPD). We previously identified miR-31 and miR-214 were dysregulated in PD. The aim this study was explore the roles pPD. recruited 25 pPD patients, 20 patients with de novo (dnPD), 24 advanced (aPD) 21 controls. Next, we investigated expression miR-214. Compared controls, found significantly upregulated while aPD...

Abstract The use of a diagnostic panel comprising multiple biomarkers has the potential to accurately diagnose Parkinson’s disease (PD). However, consisting solely plasma PD is not available. This study aimed examine ability biomarker panels for de novo using novel digital ultrasensitive immunoassay technology. We recruited 45 patients with and 20 healthy controls (HCs). concentrations α‐synuclein (α‐syn), amyloid β‐42 (Aβ42), Aβ40, phosphorylated tau 181 (p‐tau181), neurofilament light...

Substantia nigra (SN) free water has been suggested as a good surrogate marker in Parkinson's disease (PD). However, its usefulness for diagnosing prodromal PD (pPD) and monitoring progression warrants further validation.The aim was to investigate SN values across clinical stages of PD.Four groups were enrolled this study: 48 healthy controls (HC), 43 pPD patients, 50 de novo (dnPD) 49 medicated (mPD) patients. Based on diffusion tensor images, maps calculated, extracted from the anterior...

Objective Variants in the glucocerebrosidase ( GBA ) gene are most common and significant risk factor for Parkinson’s disease (PD). However, impact of variants on PD progression Chinese population remains unclear. This study aimed to explore significance status motor cognitive impairment a longitudinal cohort patients with PD. Methods The entire was screened by long-range polymerase chain reaction (LR-PCR) next generation sequencing (NGS). A total 43 -related -PD) 246 non- -mutated (NM-PD)...

Abstract Background and purpose Variants in the glucocerebrosidase ( GBA ) gene are recognized as a common important genetic risk factor for Parkinson disease (PD). However, impact of variant severity on clinical phenotype PD Chinese population remains unclear. Thus, present study aimed to determine frequency ‐related ‐PD) relationship with characteristics large cohort. Methods Long‐range polymerase chain reaction next generation sequencing were performed entire gene. was classified into...

Little is known about non-motor symptoms (NMSs) associated with the postural instability and gait difficulty (PIGD) phenotype, especially in de novo Parkinson's disease (PD) patients. The aims of this study were to compare NMSs between tremor dominant (TD) PIGD phenotypes PD patients determine factors that are subtype.In a cross-sectional conducted at our single center, 226 median duration 2 years recruited. Data, including comprehensive demographics, motor subtypes obtained. Motor...

Objective Patients with Parkinson’s disease (PD) are commonly classified into subtypes based on motor symptoms. The aims of the present study were to determine consistency between PD subtypes, assess stability over time, and explore variables influencing subtype stability. Methods This was part a longitudinal de novo patients at single center. Based three different classification systems proposed by Jankovic, Schiess, Kang, respectively categorized as tremor-dominant/indeterminate/postural...

Depression is one of the most prevalent and disturbing non-motor symptoms in Parkinson's disease (PD), with few dynamic functional connectivity (dFC) features measured previous studies. Our aim was to investigate alterations dynamics de novo patients PD depression (dPD).We performed dFC analysis on data resting-state MRI from 21 dPD, 34 without (ndPD), 43 healthy controls (HCs). Group independent component analysis, a sliding window approach, followed by k-means clustering were conducted...

Abstract Objective Glucosylceramidase ( GBA ) variants and onset age significantly affect clinical phenotype progression in Parkinson's disease (PD). The current study compared characteristics at baseline cognitive motor over time among patients having ‐related PD ‐PD), early‐onset idiopathic (early‐iPD), late‐onset (late‐iPD). Methods We recruited 88 ‐PD, 167 early‐iPD, 488 late‐iPD this study. A subset of 50 81 223 was followed up least once, with a 3.0‐year mean follow‐up time. Linear...

Parkinson's disease (PD) is a highly heterogeneous neurodegenerative disorder with varying clinical subtypes. Recently, novel classification called MNCD (Motor/Non-motor/Cognition/Dependency) has been proposed, which can also include staging based on severity. We aim to investigate staging, the and or Hoehn Yahr (H&Y) exhibits stronger correlation 39-item Disease Questionnaire (PDQ-39). In cross-sectional study conducted at our single center, 357 PD patients were recruited. Data encompassed...

Background: Subjective cognitive complaints (SCCs) and mild impairment (MCI) are common among patients with Parkinson's disease (PD). However, the relationship between SCCs MCI is not well understood. Herein, we aimed to investigate whether there any differences in prevalence risk factors of early PD without MCI. Methods: Overall, 108 newly diagnosed, untreated underwent comprehensive neuropsychological assessments. (PD-MCI) were diagnosed according level II criteria. Furthermore, measured...

The novel concept of subjective cognitive decline (SCD) in Parkinson's disease (PD) refers to impairment without concurrent objective deficits. This study aimed determine the prevalence and affective correlates SCD de novo PD patients.A total 139 patients underwent comprehensive neuropsychological evaluation. with (PD-SCD) did not meet diagnostic criteria for mild (PD-MCI) based on Movement Disorder Society Level II Criteria were defined by a Domain-5 Score ≥1 Non-Motor Symptoms...

Genetic factors play an important role in the pathogenesis of early-onset Parkinson's disease (EOPD). To date, more than 20 pathogenic genes associated with (PD) have been identified. This study aims to explore mutation spectrum EOPD and clinical characteristics carriers eastern China.We recruited 155 unrelated patients, including 8 familial 147 sporadic (age at onset ≤ 50 years). Overall, 24 known PD-associated were detected by whole exome sequencing multiplex ligation-dependent probe...

The International Parkinson and Movement Disorder Society (MDS) has published research criteria for prodromal Parkinson's disease (pPD), which includes cognitive impairment as a marker. However, the clinical features of mild (MCI) in pPD remain unknown. Our study aimed to evaluate frequency elderly China.The cross-sectional community-based recruited 2688 participants aged ≥50 years. Subjects were diagnosed with according MDS criteria. Overall, 39 22 healthy controls underwent comprehensive...

Abstract Background and objective Zishen Pingchan granule (ZPG), a traditional Chinese herbal recipe for treating Parkinson’s disease (PD), is usually used as an add-on drug with some antiparkinsonian drugs in China. The objectives of this study were to evaluate the efficacy, safety, tolerability ZPG combined pramipexole treatment depression PD (dPD). Methods A 12-week, multicenter, randomized, double-blind, placebo-controlled on was performed total 200 patients who treated but still had...

Background Depression, one of the most frequent non-motor symptoms in Parkinson’s disease (PD), was proposed to be related neural network dysfunction advanced PD patients. However, underlying mechanisms early stage remain unclear. The study aimed explore alterations large-scale networks de novo patients with depression. Methods We performed independent component analysis (ICA) on data resting-state functional magnetic resonance imaging from 21 depression (dPD), 34 without (ndPD), and 43...

The pathogenesis of cognitive impairment in Parkinson's disease (PD) patients remains unclear, and there is no ideal diagnostic tool available at present. We assessed integrated clinical features with plasma multi-modal neuroimaging biomarkers to identify mild (MCI) early drug-naive PD patients. 49 patients, including 26 MCI (PD-MCI) 23 normal cognition (PD-NC), 20 controls were recruited. Plasma markers [α-synuclein, beta-amyloid 1-40 (Aβ40), 1-42 (Aβ42), phosphorylated Tau 181 (p-Tau181)...

Background Depression in Parkinson’s disease (PD) is identified and diagnosed with behavioral observations neuropsychological measurements. Due to the large overlaps of depression PD symptoms clinical manifestations, it challenging for neurologists distinguish diagnose (DPD) early stage PD. The advancement magnetic resonance imaging (MRI) technology provides potential utility diagnosis DPD. This study aimed explore alterations functional structural MRI DPD produce neuroimaging markers...

Although various studies have reported a high prevalence of depression among Parkinson's disease (PD) patients, the pathophysiological mechanism in PD (DPD) is still unclear. The core region reward network, ventral striatum (VS), critical occurrence and development DPD. This study aimed to explore altered functional connectivity (FC) VS subregions We recruited 20 DPD 37 non-depressed (NDPD) 41 healthy controls (HC) matched age, gender, years education. patients' diagnosis with was de-novo....