Background: Ultrasound (US) examination is helpful in the differential diagnosis of thyroid nodules (malignant vs. benign), but its accuracy relies heavily on examiner experience. Therefore, aim this study was to develop a less subjective diagnostic model aided by machine learning. Methods: A total 2064 (2032 patients, 695 male; Mage = 45.25 ± 13.49 years) met all following inclusion criteria: (i) hemi- or thyroidectomy, (ii) maximum nodule diameter 2.5 cm, (iii) conventional US and...

Identification of cancer stem cells (CSCs) and their behaviors will provide insightful information for the future control human cancers. This study investigated CD44 CD24 cell surface markers as breast CSC in vitro vivo.Flow cytometry with was used to sort MCF7 scanning electron microscopy (SEM), tumor invasion assay, nude mouse xenograft assay.Flow assay using sorted into four subsets, i.e., CD44+/CD24-/low, CD44-/CD24+, CD44+/CD24+, CD44-/CD24-. The SEM data showed that there were many...

The HPV vaccination is a crucial line of defensing against cervical cancer. As result government support and positive publicity from the majority media, craze for has occurred in China. Besides, intentions to get vaccine among women appropriate age also influenced by families' friends' attitudes perceptions toward vaccine. Therefore, purpose this study was investigate how related information exposure injunctive norms affect young Chinese women's receive vaccine.A structural equation model...

Background Pancreatic cancer is an extremely malignant disease that poses a serious threat to the mental health of patients. Many patients now use social media for online support. However, impact on currently inconsistent in academic community. Therefore, this study aimed examine mediating effects support and psychological resilience relationship between pancreatic Methods Four hundred twenty-five valid questionnaires were collected through convenience sampling. All data processed using SPSS...

Long COVID is a public health problem that cannot be ignored, and it critical to understand the long patients' living situations support this group through their illness narratives. This study based on grounded theory, coded self-produced texts of patients largest online Q&A community in China, Zhihu APP, an attempt explore experiences China how they adapt reconstruct lives. The results show face not only threat pain from itself, but also social stigma discrimination. Patients turn into...

The EarlyCDT®-Lung test was the first autoantibody-based diagnostic tool for lung cancer, which developed with a panel of recombinant protein antigens. To confirm whether antibody linear peptide antigens has similar power to that whole molecules, present work then undertaken develop an in-house enzyme-linked immunosorbent assay derived from annexin A1 (ANXA1) and DEAD box 53 (DDX53), have been used test. A total 272 patients non-small cell cancer (NSCLC) 227 control subjects matched in age...

Kindlin-2 is involved in activating the integrin signaling pathway which plays an important role regulating cancer cell invasion. However, of kindlin-2 may vary among types. The aim this study was to explore possible association between and clear renal carcinoma (ccRCC), its potential prognosis ccRCC. Immunohistochemistry assays were used examine expression levels tissues obtained from 336 patients with correlation pathologic variables then analyzed. In addition, survival time analyzed by...

Background Depression, one of the most frequent non-motor symptoms in Parkinson’s disease (PD), was proposed to be related neural network dysfunction advanced PD patients. However, underlying mechanisms early stage remain unclear. The study aimed explore alterations large-scale networks de novo patients with depression. Methods We performed independent component analysis (ICA) on data resting-state functional magnetic resonance imaging from 21 depression (dPD), 34 without (ndPD), and 43...

The pathogenesis of cognitive impairment in Parkinson's disease (PD) patients remains unclear, and there is no ideal diagnostic tool available at present. We assessed integrated clinical features with plasma multi-modal neuroimaging biomarkers to identify mild (MCI) early drug-naive PD patients. 49 patients, including 26 MCI (PD-MCI) 23 normal cognition (PD-NC), 20 controls were recruited. Plasma markers [α-synuclein, beta-amyloid 1-40 (Aβ40), 1-42 (Aβ42), phosphorylated Tau 181 (p-Tau181)...

Overexpression of the p16 protein has been reported in breast cancer and may trigger secretion antibodies against itself. Circulating anti-p16 that were detected with a recombinant have cancer. The present study was designed to determine whether levels circulating IgG antibody protein-derived linear antigens are altered An enzyme-linked immunosorbent assay (ELISA) developed in-house peptide derived from 152 female patients 160 healthy subjects. Student's T-test revealed exhibited...

Recurrent cervical cancer is a clinically complex disease that difficult to treat. There are numerous treatment options, but the results achieved by each poor. External‑beam radiation therapy of pelvic lymph drainage area, in combination with intracavitary afterloading or interstitial implantation source (i.e., brachytherapy), current standard radiotherapy regimens used high‑risk clinical targets. However, there few reports concerning use iodine‑125 (125I) seed brachytherapy recurrent...

The present study was undertaken to detect circulating IgG antibodies peptide antigens derived from baculoviral IAP repeat-containing protein 5 isoform 2 (BIRC5) and myc proto-oncogene (MYC) in cervical cancer. A total of 107 female patients with cancer stages I II, 130 healthy subjects were recruited for analysis BIRC5 MYC. Student's t-test showed significant differences levels anti-BIRC5 (t = -4.27, df 235, P < 0.0001) anti-MYC 3.51, 232, 0.0005) between the patient group control group....

Objective The thalamus is an integrative hub of motor circuits in Parkinson’s disease (PD). This study aimed to investigate the alterations structure and functional connectivity (FC) thalamic subregions tremor-dominant (TD) subtype postural instability gait difficulty (PIGD) PD. Methods A total 59 drug-naïve patients (24 TD 35 PIGD) 37 healthy controls were recruited. volumes calculated using FreeSurfer. Functional analysis resting-state MRI (rsfMRI) was conducted on subregions. Finally,...

To analyze the main reasons for screening failure in process of healthy subjects phase I clinical trials and coping strategies.We retrospectively collected data from 1,640 12 conducted between April 2019 July 2020 at First Affiliated Hospital Bengbu Medical College. The were statistically analyzed (χ2 test), correlation studies to explore factors associated with failure.Among subjects, 632 (38.5%) successfully passed screening, 1,008 (61.5%) failed screening. Abnormal laboratory test results...

Thymic lymphoma is a highly invasive and even metastatic cancer. This study investigated the effects of mesenchymal stem cells (MSCs) transfusion on cell cycle, proliferation, CD3 expression, mutation frequency T receptor using mouse model thymic lymphoma. C57BL/6J young models thymoma were injected with MSCs. Six months later, thymus was taken for pathological examination flow cytometry studies. The labeled anti-CD4, CD8, CD3, propidium iodide, or CFDA-SE, proliferation kinetics, receptor,...

Objective To provide accurate location for pedicle fixation with the help of computerassisted navigational template in hangman fracture surgery. Methods CT scanning patients Hangman was performed, and three dimensional (3D) model constructed by using software MIMICS 10.01. The 3D then exported STL format, opened a workstation running UG imageware12.0. optimal channel located according to reverse engineering. A virtual established laminar anatomic trait. physical vertebrae were manufactured...

Wnt / β-catenin signaling pathway play an important role in the development of tumor. Here we try to study its tumor through investigating expressions β-catenin, c-myc and cyclin D1 thymic lymphomas mice induced by ionizing radiation. The mouse model irradiation was made according Kaplan' method. were killed thymus removed out 3 6 months. characteristics structure observated histopathology protein expression positions detected immunohistochemistry. pre-cancerous changes lymphoma seen months...