PurposeThe purpose of this study was to determine the risk factors associated with pneumonia, acute respiratory distress syndrome (ARDS), and clinical outcome among patients novel coronavirus disease 2019 (COVID-19).MethodsThis a cross-sectional multicenter study. A total 95 infected COVID-19 were enrolled. The diagnostic standard polymerase chain reaction detection target genes (2019-nCoV). Clinical, laboratory, radiologic results, as well treatment data, obtained. ARDS defined an...

Abstract Osteoporosis is the most common bone metabolic disease that affects health of middle-aged and elderly people, which hallmarked by imbalanced remodeling a deteriorating immune microenvironment. Magnesium calcium are pivotal matrix components participate in formation process, especially microenvironment regulation stages. Nevertheless, how to potently deliver magnesium tissue remains challenge. Here, we have constructed multifunctional nanoplatform composed calcium-based upconversion...

ABSTRACT Dengue, leptospirosis, and malaria are among the most common etiologies of systemic undifferentiated febrile illness (UFI) travelers to developing world, these pathogens all have potential cause life-threatening in returned travelers. The current study describes development an internally controlled multiplex nucleic acid amplification test for detection dengue virus (DENV) Leptospira Plasmodium species, with a specific callout falciparum (referred as UFI assay). During analytical...

Aims This study aims to determine the optimal number of oocytes retrieved so that patients with polycystic ovary syndrome (PCOS) receiving in vitro fertilization (IVF) can obtain best cumulative live birth rate (CLBR) and after fresh embryo transfer. Methods is a retrospective 1,419 PCOS who underwent their first IVF cycle at Second Hospital Hebei Medical University from January 2014 December 2021. Multivariable regression analysis was performed adjust for factors known independently affect...

Abstract Objective To evaluate whether prophylactic chemotherapy (P-chem) increased the drug resistance rate of postmolar GTN and first-line should be different from P-chem. Methods Postmolar received P-Chem was defined as group. without P-chem randomly selected control group according to ratio 1:3 (P-chem:control) matched by age for low risk high separately. Results Totally 455 low-risk 32 high-risk patients were included. WHO score, cycles achieve hCG normalization resistant similar...

Ovarian aging is characterized by a gradual decline in quantity and quality of oocytes lower chance fertility. Better understanding the genetic modulation during ovarian can further address available treatment options for aging-related diseases fertility preservation.A novel technique spatial transcriptomics (ST) was used to investigate transcriptome features rat ovaries. Transcriptomes from ST spots young aged ovaries were clustered using differentially expressed genes. These data analyzed...

We aim to explore the effects of follicular output rate (FORT) on cumulative clinical pregnancy (CCPR) and live birth (CLBR) in polycystic ovary syndrome (PCOS) patients with different characteristics undergoing

Introduction Organ donation after citizens’ death was initiated in the 2010s and great progress had been made since then. But willingness of organ still very low. Our research aimed to investigate knowledge, attitudes medical students identified factors attributing donation. Methods A simple randomized sampling method adopted. Medical who were selected from two universities investigated November 2015 January 2016 Tianjin, China. Numerical data summed up as means standard deviations....

To investigate the significance of lung nodule in hydatidiform mole, we retrospectively compared clinical outcomes those patients treated with different strategies.The were divided into three groups: chemotherapy immediately once was detected (group 1, n=17), delayed until human chorionic gonadotrophin (hCG) level met diagnostic criteria for gestational trophoblastic neoplasia (GTN) 2, n=18), and hCG surveillance alone normalized spontaneously 3, n=18). The parameters these collected...

To analyze the main reasons for screening failure in process of healthy subjects phase I clinical trials and coping strategies.We retrospectively collected data from 1,640 12 conducted between April 2019 July 2020 at First Affiliated Hospital Bengbu Medical College. The were statistically analyzed (χ2 test), correlation studies to explore factors associated with failure.Among subjects, 632 (38.5%) successfully passed screening, 1,008 (61.5%) failed screening. Abnormal laboratory test results...

Tarlov cysts adjacent to the spinal cord are usually asymptomatic and found incidentally via magnetic resonance imaging. On rare occasions, they increase in size produce symptoms resembling disk herniation. We report a case of sacral cyst resulting premature ejaculation 32-year-old man who presented with pelvic pain acquired ejaculation. Spinal nerve root decompression, excision intraspinal cyst, adhesion release surgery significantly improved his at six-month follow-up.

Objective: To analyze the different metabolites and related metabolic pathways in follicular fluid embryo culture of polycystic ovary syndrome (PCOS) non-PCOS groups. Finding markers predictable for clinical outcomes vitro fertilization-embryo transfer (IVF-ET) treatment. Design: Single center cross-sectional study Setting: Center Reproductive Medicine, Zhengzhou University First Affiliated Hospital. From September 2019 to October Population sample: 60 women who underwent IVF-ET were...

The present study aimed to explore the clinicopathological characteristics, potential heterogeneity and prognostic factors in synchronous bilateral breast cancer (SBBC).We performed a retrospective review paired comparison of characteristics 114 patients with SBBC Peking Union Medical College Hospital from January 2008 September 2019. significance triple negativity status coexistence ductal carcinoma situ (DCIS) invasive carcinomas no special type (IDC-NST) was analyzed SBBC.Most lesions on...

Researches in China on the innovation ability and development needs of young scientific research talents is not enough. The survey aimed to shed light status quo, problems, capabilities among researchers terms orientation, atmosphere, platform support, training mechanisms, measures.From January March 2022, a randomly-selected method was used conduct web-based self-made questionnaire 6 university affiliated hospitals 5 provinces China. Intergroup comparisons were based chi-square test or...

Abstract The impact of population mobility is non-negligible on the spread infectious diseases. In this study, we construct a network SIS model that accounts for between regions, using nonlinear infection rate and dividing infected into symptomatic asymptomatic groups. First, study analyses stability equilibrium points by constructing Lyapunov function validating it numerical experiments. Secondly, special form basic regeneration number was attained next generation matrix method. This result...

Abstract Background: Intermediate-risk APE patients usually defined as hemodynamically stable, comprehending a great therapeutic dilemma , since some can deteriorate and eventually require reperfusion therapy .To evaluate the predictive values of short-term prognosis for intermediate-risk acute pulmonary embolism (APE) based on clinical data. Methods : A retrospective cohort 74 confirmed by computed tomography angiography (CTPA) was analyzed in present study. Adverse events outcomes included...