Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer in adults. Previous studies our laboratory found that long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was upregulated HCC cells, which could affect metastasis and invasion of HCC. However, underlying mechanism remains unknown. Herein, we studied interaction between MALAT1 miR-140 on regulation angiogenesis immunosuppressive properties. We revealed expression VEGF-A significantly...

Abstract Background Acute liver failure (ALF) is a syndrome of severe hepatocyte injury with high rate mortality. Hepatitis B virus (HBV) infection the major cause ALF worldwide, however, underlying mechanism by which HBV leads to has not been fully disclosed. Methods D-GalN-induced model and LPS/D-GalN-induced mice were used investigate effects X protein (HBx) in vitro vivo, respectively. Cell viability levels Glutathione (GSH), malondialdehyde (MDA) iron measured using commercial kits. The...

PurposeThe purpose of this study was to determine the risk factors associated with pneumonia, acute respiratory distress syndrome (ARDS), and clinical outcome among patients novel coronavirus disease 2019 (COVID-19).MethodsThis a cross-sectional multicenter study. A total 95 infected COVID-19 were enrolled. The diagnostic standard polymerase chain reaction detection target genes (2019-nCoV). Clinical, laboratory, radiologic results, as well treatment data, obtained. ARDS defined an...

Increasing evidence supports the significance of long non-coding RNA in cancer development. Several recent studies suggest oncogenic activity metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) hepatocellular carcinoma. In this study, we explored molecular mechanisms by which MALAT1 modulates carcinoma biological behaviors. We found that microRNA-204 was significantly downregulated sh-MALAT1 HepG2 cell and 15 tissues quantitative real-time polymerase chain reaction analysis....

This study focused on the mental health of people living with HIV(PLWHIV) and explored their relationship between loneliness perceived social support, related quality life (HRQoL) a method structural equation model. We collected clinical psychological data from consecutively enrolled PLWHIV. A total 201 PLWHIVs were measured self-reporting survey instruments UCLA Loneliness Scale, Self-Rating Depression Anxiety Social Support Ratio Scale Short Form Health Survey-36. The levels loneliness,...

Abstract We aimed to analyze the efficacy and safety of an inactivated SARS‐CoV‐2 vaccine in people living with HIV (PLWH). A total 143 PLWH 50 healthy individuals were included this study. commercially available magnetic chemiluminescence enzyme immunoassay kit was used detect serum IgG IgM antibodies against SARS‐CoV‐2. Serum levels SARS‐CoV‐2‐specific significantly higher control group than ( p = 0.001). Overall, 76% detected seropositivity compared 58% 0.024). In seropositivity, CD4+...

Background Although the introduction of direct-acting antiviral drugs (DAAs) has greatly enhanced prognosis for hepatitis C, timely diagnosis and treatment C virus (HCV) infection remain a severe challenge in China.

Previous studies have shown changes in gut microbiota after human immunodeficiency virus (HIV) infection, but there is limited research linking the of people living with HIV (PLWHIV) to metabolic diseases. A total 103 PLWHIV were followed for 48 weeks anti-retroviral therapy (ART), demographic and clinical data collected. Gut microbiome analysis was conducted using metagenomic sequencing fecal samples from 12 individuals. Nonalcoholic fatty liver disease (NAFLD) diagnosed based on controlled...

Abstract Talaromyces marneffei (T. marneffei) co-infection remains a significant cause of mortality in people living with HIV (PLWH). Although early detection individuals at high risk is essential, there lack markers to predict outcomes. Our multicenter retrospective study included 282 individuals, 95 treatment-naïve PLWH T. infection and 187 without opportunistic infection. Clinical data were collected six inflammation-related indices calculated: Systemic Immune-Inflammation Index (SII),...

Aim: To evaluate health-related quality of life (HRQoL) chronic hepatitis B (CHB) and virus (HBV) related cirrhosis patients analyzed specific differences in all dimensions HRQoL. Methods: A total 349 met selection criteria were enrolled. The 36-Item Short-Form Health Survey was adopted. Results: Results showed that the physiological HRQoL cirrhotic group significantly lower than non-cirrhotic (P = 0.003), psychological also 0.006). negatively correlated with liver stiffness 0.001). We...

Malnutrition is one of the most critical factors affecting patients' risk infection and length stay, it may affect prognosis patients with sepsis. There have been no studies that applied nutritional screening tools to stratify sepsis according prognosis.We retrospectively analyzed clinical data 425 adult inpatients who were grouped based on (NRS) score, including a nutrition disease severity age score. Prognostic using univariate multivariate regression analyses.Of enrolled patients, 174 had...

The long-term outcomes of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) remain not well known. This study aimed to investigate whether aMAP score can predict re-hospitalization, hepatocellular carcinoma (HCC) occurrence and mortality in HBV-ACLF.A total 82 diagnosed HBV-ACLF survived over 6 months were enrolled. median follow-up period was 105 (75.9, 134.1) months. Cox proportional hazards or logistic regression analysis used determine independent risk...

Long noncoding RNA Mirt2 has been proven to be a suppressor of lipopolysaccharide (LPS) (a key player in sepsis)-induced inflammation responses. Therefore, may also participate sepsis. This study was carried out analyze the interactions between and microRNA-1246 (miR-1246) sepsis, with specific focus on sepsis-induced acute lung injury (sepsis-ALI).

The global prevalence of metabolic syndrome (MetS) in people living with HIV (PLWH) is on the rise post era antiretroviral therapy (ART). Nevertheless, there are no validated predictive models available for assessing risk MetS this specific population. This study included PLWH who participated annual follow-ups at Southern Medical University Nanfang Hospital from September 2022 to November 2023. Participants enrolled were divided into training set and validation based follow-up duration. We...

Abstract Platelets are critical regulators of liver regeneration, but the mechanisms still not fully understood. have been shown to contain a wide variety microRNAs (miRNAs) and play an important role in many diseases. However, mechanism that how platelet microparticles (PMPs)‐derived miRNA regulate hepatocyte proliferation is very clear. In this study, we successfully isolated identified PMPs. We also found PMPs, which could be well integrated into HHL‐5 cells, upregulate level miR‐25‐3p...

Background Tuberculous meningitis (TBM) is one of the most severe forms tuberculosis. Previous studies reported that hepatitis B virus (HBV) infection could increase risk antituberculosis drug-induced liver injury (ATB-DILI) in pulmonary tuberculosis patients. To date, only a few exist on effect HBV TBM.Methods This inpatient study retrospectively analyzed medical records patients who were diagnosed with TBM between June 2002 and 2018. Statistical analysis was used to reveal difference...

This study aims to investigate the relationship between estimated pulse wave velocity (ePWV) and metabolic syndrome (MetS) in people living with HIV (PLWH), proposing a novel convenient predictor for early detection of MetS PLWH.