A5100448067- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Myasthenia Gravis and Thymoma
- Restless Legs Syndrome Research
- Nuclear Receptors and Signaling
- Ginkgo biloba and Cashew Applications
- Epilepsy research and treatment
- Balance, Gait, and Falls Prevention
- Nerve injury and regeneration
- Parkinson's Disease and Spinal Disorders
- RNA Interference and Gene Delivery
- Neurotransmitter Receptor Influence on Behavior
- Acute Ischemic Stroke Management
- Neurological diseases and metabolism
- Vestibular and auditory disorders
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Drug Transport and Resistance Mechanisms
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Immune Cell Function and Interaction
XinHua Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
First Affiliated Hospital of Zhengzhou University
2022
Sun Yat-sen University Cancer Center
2017
Ruijin Hospital
2004
Uncertainty exists over the size of potential beneficial effects medical treatments targeting hematoma growth in intracerebral hemorrhage (ICH). We report associations parameters on clinical outcomes pilot phase, Intensive Blood Pressure Reduction Acute Cerebral Hemorrhage Trial (INTERACT1) (ClinicalTrials.gov NCT00226096).In randomized patients with both baseline and 24-hour brain CT (n = 335), between measures absolute relative 90-day poor death dependency (modified Rankin Scale score 3-5)...
This study investigated the influence of lockdown during 2019 coronavirus disease (COVID-19) pandemic on quality life patients with Parkinson's (PD).We conducted a questionnaire survey involving 113 PD from Xihu District, Hangzhou, Zhejiang. During epidemic prevention and control period (February 1 to March 31, 2020), enrolled were asked fill out questionnaires, including "COVID-19 Questionnaire for Patients Period Epidemic Prevention Control" "39-item Disease (PDQ-39)." phase gradual...
Abstract Background Due to the outbreak and rapid spread of coronavirus disease 2019 (COVID-19), more than 160 million patients have become convalescents worldwide date. Significant alterations occurred in gut oral microbiome metabonomics with COVID-19. However, it is unknown whether their characteristics return normal after 1-year recovery. Methods We recruited 35 confirmed provide specimens at discharge one year later, as well healthy controls. A total 497 samples were prospectively...
to explore the association between cerebral small-vessel diseases (CSVDs) and motor symptoms in Parkinson's disease (PD).137 PD patients were recruited into study. Detailed symptoms, including tremor, rigidity, bradykinesia, axial impairment, evaluated using Unified Rating Scale (UPDRS). Non-motor cognition, anxiety, depression, Montreal Cognitive Assessment (MoCA), Hamilton anxiety scale (HAMA), depression (HAMD). Brain MRI was used assess subtypes of CSVDs, lacunes, enlarged perivascular...
Postoperative myasthenic crisis (POMC), which occurs specifically after thymectomy in myasthenia gravis (MG) patients, is a serious complication with known risk factors such as prior crisis. However, the predictive value of perioperative blood lactic acid levels (BLAL) for POMC remains unclear. This study aims to determine whether changes BLAL can predict MG patients undergoing thymectomy. A total 340 diagnosed and at First Affiliated Hospital Sun Yat-sen University were enrolled (January...
Background: Levodopa remains the most effective drug in treatment of Parkinson's disease. However, long-term administration levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying dyskinesia are not fully understood. Methods: In this study, we prepared methyl ester (LDME)/benserazide-loaded nanoparticles, which can release LDME and benserazide a sustained manner. Dyskinesia was induced rats by repeated then treated with plus or same dose...
Background and Purpose— We aimed to develop a risk score (intracerebral hemorrhage–associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated (SAP) after ICH. Methods— The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) validation (40%) cohorts. Variables routinely collected at presentation used SAP For testing added value of hematoma volume measure, we separately 2...
Abstract Background Paroxysmal kinesigenic dyskinesia is a spectrum of involuntary dyskinetic disorders with high clinical and genetic heterogeneity. Mutations in proline‐rich transmembrane protein 2 have been identified as the major pathogenic factor. Objectives We analyzed 600 paroxysmal patients nationwide who were by China Dyskinesia Collaborative Group to summarize phenotypes features provide new thoughts on diagnosis therapy. Methods The was composed departments neurology from 22...
Chronic levodopa (L-dopa) treatment in Parkinson's disease (PD) is often associated with the development of motor complications, but corresponding epidemiological data rare Chinese PD patients. The present survey was to investigate prevalence rate wearing-off (WO) and dyskinesia among patients China. From May 2012 October 2012, a 3-step registry for wearing off receiving therapy performed simultaneously at 28 movement disorders clinics There were 1,558 fulfilling inclusion criteria. Among...
Objective Myasthenic crisis (MC) is considered the most severe adverse event in patients with myasthenia gravis. The present retrospective study was performed to evaluate predictors of clinical outcomes MC. Methods medical charts 33 (19 women, 14 men) 76 MC attacks from 2002 2014 were retrospectively reviewed. Early extubation (≤7 days) and prolonged ventilation (>15 during used assess patient outcomes. Results Among patients, 24 (72.7%) had positive acetylcholine receptor antibody test...
Objective Parkinson’s disease (PD) is marked not only by motor symptoms but also neuropsychiatric manifestations, including demoralization, apathy, and depression. Understanding the clinical distribution characteristics of these co-occurring crucial for improving quality life PD patients. Methods This study enrolled 195 Chinese patients from Xinhua Hospital affiliated to Shanghai Jiao Tong University School Medicine. The involved analyzing related simultaneous presence depression in Linear...
Abstract Background Parkinson’s disease (PD) is a slowly progressive neurodegenerating that may eventually lead to disabling condition and pose threat the health of aging populations. This study aimed explore association two potential risk factors, selenium cadmium, with prognosis as well their interaction effect. Methods Data were obtained from National Health Nutrition Examination Survey (NHANES) 2005–2006 2015–2016 Death Index (NDI). Participants classified patients by self-reported...
Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) has been shown to confer strong neuroprotective effects in acute ischemic stroke (AIS). However, as the vast majority of research findings date are based its functions microglia, precise role TREM2 astrocytes after AIS is unknown. Here, both loss‐ and gain‐of‐function experiments were employed investigate how astrocytic influences pathogenesis vivo vitro. Our results demonstrated that cerebral ischemia triggered induction...
Objective. To investigate the current use of integrative therapies (IT) in treatment patients with amyotrophic lateral sclerosis (ALS). Methods. A cross-sectional, multicenter clinical epidemiological survey was conducted 12 hospitals Shanghai. We investigated type and frequency IT determined whether correlated demographic, social, or disease-specific characteristics our patient population. Results. total 231 (89.5%) 258 ALS were eligible for study 229 (99% all) reported at least one ALS....