A5100688602- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Housing Market and Economics
- Complex Systems and Time Series Analysis
- Nuclear Receptors and Signaling
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Financial Risk and Volatility Modeling
- Monetary Policy and Economic Impact
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Complex Network Analysis Techniques
- Neurological diseases and metabolism
- Advanced Breast Cancer Therapies
- Banking stability, regulation, efficiency
- Financial Markets and Investment Strategies
- Botulinum Toxin and Related Neurological Disorders
- Advanced Graph Neural Networks
- Market Dynamics and Volatility
- Medical Research and Treatments
- Gut microbiota and health
- Insurance and Financial Risk Management
- Global Financial Crisis and Policies
- RNA regulation and disease
- Dysphagia Assessment and Management
Daping Hospital
2024-2025
Army Medical University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
University of Hull
2012-2025
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Air Force Medical University
2024
Shanghai East Hospital
2018-2024
University of Aberdeen
2008-2024
Baotou Medical College
2024
The most common inherited form of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting adult motoneurons, is caused by dominant mutations in the ubiquitously expressed Cu 2+ /Zn superoxide dismutase (SOD1). Recent studies suggest that glia may contribute to motoneuron injury animal models familial ALS. To determine whether expression mutant SOD1 (mSOD1 G93A ) CNS microglia contributes injury, PU.1 −/− mice are unable develop myeloid and lymphoid cells received bone...
Abstract Objective Gut microbiota changes before the onset of Alzheimer's disease (AD) and alterations could be detected in stage mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers dementia. Background AD is most common cause dementia, MCI predementia state. Recent studies suggest gut microbial communities associated with AD, whereas dementia has not been discovered characterized humans. New/Updated Hypothesis We hypothesize that dysbiosis happens stage. Patients...
Abstract Recent studies suggest that microglia over‐expressing mutant human superoxide dismutase (mSOD1 G93A ) may contribute to motoneuron death in a transgenic mouse model of familial amyotrophic lateral sclerosis. To further assess the relative neurotoxicity wild‐type microglia, mSOD1 and SOD1, we used primary cultures motoneurons presence absence lipopolysaccharide stimulation. Following activation with lipopolysaccharide, released more nitric oxide, superoxide, less insulin‐like growth...
Identification of the gut microbiome compositions associated with disease has become a research focus worldwide. Emerging evidence revealed presence microbiota dysbiosis in Parkinson's disease. In this study, we aimed to identify and subsequently screen validate potential diagnostic biomarkers This case-control study investigated microbial genes faeces from 40 volunteer Chinese patients their healthy spouses using shotgun metagenomic sequencing. Furthermore, identified specific gene markers...
Parkinson's disease (PD) is a common neurodegenerative characterized by motor issues and range of non-motor symptoms. Microbial therapy may be useful approach for the treatment PD. However, comprehensive analyses impact probiotic supplementation on symptoms are still lacking mechanisms whereby works remain unclear. This study investigated Lacticaseibacillus paracasei strain Shirota (LcS) clinical responses, gut microbiota faecal metabolites in PD patients. Patients (n = 128) were randomised...
A growing body of evidence showed that gut microbiota dysbiosis might be associated with the pathogenesis Parkinson's disease (PD). Microbiota-targeted interventions could play a protective role in PD by regulating microbiota-gut-brain axis. Sodium butyrate (NaB) improve and other neuropsychiatric disorders. However, potential mechanism complex interaction between NaB communication needs further investigation.C57BL/6 mice were subjected to rotenone-induced model treated intragastrically for...
Recent studies suggest that motor neuron (MN) death may be non-cell autonomous, with cell injury mediated by interactions involving non-neuronal cells, such as microglia and astrocytes. To help define these interactions, we used primary MN cultures to investigate the effects of activated lipopolysaccharide or IgG immune complexes from patients amyotrophic lateral sclerosis. Following activation, induced injury, which was prevented a microglial iNOS inhibitor well catalase glutathione....
Abstract Microglia‐mediated cytotoxicity has been implicated in models of neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease, but few studies have documented how neuroprotective signals might mitigate cytotoxicity. To explore the mechanism anti‐inflammatory cytokines, we applied interleukin‐4 (IL‐4) to primary microglial cultures activated by lipopolysaccharide well microglia cocultured with motoneurons. increased nitric oxide...
Curcumin,a natural polyphenol obtained from turmeric,has been implicated to be neuroprotective in a variety of neurodegenerative disorders although the mechanism remains poorly understood. The results our recent experiments indicated that curcumin could protect dopaminergic neurons apoptosis 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model Parkinson's disease (PD). death and loss axon striatum were significantly suppressed by MPTP model. Further studies showed inhibited JNKs...
Microglia in the central nervous system (CNS) were reported to play crucial role neurodegeneration. Previous studies showed that P2Y6 receptor (P2Y6R) mainly contributed microglia activation and phagocytosis CNS. However, level of P2Y6R Parkinson's disease (PD) patients is unclear. Therefore, we measured PD speculated whether it could be a potential biomarker for PD. Given on basis was higher patients, further explored mechanisms underlying pathogenesis We tested expression peripheral blood...
Emerging evidence suggests that the microbiota present in feces plays a role Parkinson's disease (PD). However, alterations of microbiome blood PD patients remain unknown. To test this hypothesis, we conducted case-control study to explore compositions Chinese patients. Microbiota communities 45 and their healthy spouses were investigated using high-throughput Illumina HiSeq sequencing targeting V3-V4 region 16S ribosomal RNA (rRNA) gene. The relationships between clinical characteristics...
<h3>Background and Objectives</h3> Interindividual variability in levodopa efficacy is a challenge for the personalized treatment of Parkinson disease (PD). Gut microbiota might represent new approach medicine. Recently, novel microbial metabolism pathway was identified, which mediated by tyrosine decarboxylase mainly encoded gene (<i>tyrDC</i>) <i>Enterococcus faecalis</i>. In this study, we aimed to identify whether abundance <i>tyrDC</i> <i>E faecalis</i> associated with responsiveness...
Loss of function mutations DJ-1 (PARK7) have been linked to the pathogenesis Parkinson's disease. Antioxidative stress is one multi-protective functions DJ-1, and oxidation cysteine 106 has proposed regulate protective activity DJ-1. Uncoupling protein 4 (UCP4) located in inner membrane mitochondria protect against oxidative stress. In this study, we used neuronal (SH-SY5Y) cells knockout mice elucidate whether regulated via modulating expression UCP4, underlying mechanism. The downstream...