A5050152095- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Multimodal Machine Learning Applications
- Advanced Image and Video Retrieval Techniques
- Context-Aware Activity Recognition Systems
- Neurological disorders and treatments
- MRI in cancer diagnosis
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Non-Invasive Vital Sign Monitoring
- Nerve injury and regeneration
- Computer Graphics and Visualization Techniques
- Virus-based gene therapy research
- Heart Rate Variability and Autonomic Control
- Cerebrovascular and Carotid Artery Diseases
- Morphological variations and asymmetry
Hvidovre Hospital
2019-2025
Copenhagen University Hospital
2019-2025
Sun Yat-sen University
2023-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2023-2025
Japan Advanced Institute of Science and Technology
2021-2023
Max Planck Institute for Biological Cybernetics
2015-2022
Data Assurance and Communication Security
2020-2022
Wuhan University of Technology
2022
Huaqiao University
2020-2021
Soochow University
2021
Microglial activation and oxidative stress are significant components of the pathology Parkinson9s disease (PD), but their exact contributions to pathogenesis unclear. We have developed an <i>in vitro</i> model nigral injury, in which lipopolysaccharide-induced microglial leads injury a dopaminergic cell line (MES 23.5 cells) neurons primary mesencephalic cultures. The microglia also activated by PD IgGs presence low-dose dopa-quinone- or H<sub>2</sub>O<sub>2</sub>-modified membranes not...
Continuously monitoring the ECG signals over hours combined with activity status is very important for preventing cardiovascular diseases. A traditional holter often inconvenient to carry because it has many electrodes attached chest and heavy. This work proposes a wearable, low power context-aware system integrated built-in kinetic sensors of smartphone self-designed sensor. The wearable sensor comprised fully analog front-end (AFE), commercial micro control unit (MCU), secure digital (SD)...
Physical activity (PA) recognition has recently become important in monitoring for the public healthcare. Although body-worn sensors are well suited to collect data on patterns long periods of time, users may forget wear special microsensors. On contrary, more and people take smartphone with them almost anytime. At present, most popular smartphones have three built-in kinematic (triaccelerometer, gyroscope, magnetic sensor) which could be utilized recognize PA. This study a PA found out...
Significance The role of astrocytes on brain function is controversial in many aspects. It remains challenging to specify the vivo functional impact astrocytic calcium signal when mediating vasodilation/constriction at varied physiological or pathophysiological conditions. Here, we applied simultaneous fMRI and GCaMP-mediated Ca 2+ optical fiber recording detect distinct signals (evoked vs. intrinsic) coupled positive negative blood-oxygen-level-dependent signals, respectively concurrently,...
Recent studies suggest that motor neuron (MN) death may be non-cell autonomous, with cell injury mediated by interactions involving non-neuronal cells, such as microglia and astrocytes. To help define these interactions, we used primary MN cultures to investigate the effects of activated lipopolysaccharide or IgG immune complexes from patients amyotrophic lateral sclerosis. Following activation, induced injury, which was prevented a microglial iNOS inhibitor well catalase glutathione....
In this study, a fall detection system based on the data acquired from waist-mounted smartphone has been developed in real-time environment. The built-in tri-accelerometer was utilized to collect information about body movement. At same time, is able classify for activity recognition. Body motion can be classified into five different patterns, i.e. vertical activity, lying, sitting or static standing, horizontal and fall. If suspected, an automatic Multimedia Messaging Service (MMS) will...
Abstract The apolipoprotein E ( APOE ) ɛ4 allele is a well‐established genetic risk factor for Alzheimer's disease (AD). Recent research has demonstrated an ɛ4‐mediated modulation of intrinsic functional brain networks in cognitively normal individuals. However, it remains largely unknown whether and how affects the brain's network architecture patients with AD. Using resting‐state MRI graph‐theory approaches, we systematically investigated topological organization whole‐brain 16 carriers 26...
Traditional activity recognition solutions are not widely applicable due to a high cost and inconvenience use with numerous sensors. This paper aims automatically recognize physical the help of built-in sensors widespread smartphone without any limitation firm attachment human body. By introducing method judge whether phone is in pocket, we investigated data collected from six positions seven subjects, chose five signals that insensitive orientation for classification. Decision trees (J48),...
We used diffusion MRI and x-ray synchrotron imaging on monkey mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. compared structure corpus callosum crossing regions investigated differences cuprizone-induced demyelination mouse versus healthy controls. Our findings revealed common principles that apply despite varying patterns observed species; small axonal fasciculi major bundles formed laminar structures with angles, according...
Summary Aims To explore the effect of fucoidan treatment on oxidative stress‐mediated dopaminergic neuronal damage and its potential mechanisms. Methods The was investigated in a 6‐hydroxydopamine (6‐OHDA) rat model PD, an animal considered appropriate for preclinical studies PD therapy. effects behavior survival ratio neurons were investigated. We further observed microglia NADPH oxidases‐1 (Nox1), family enzymes generating reactive oxygen species ( ROS ). Results found that chronic...
Fine-grained Image-text retrieval is challenging but vital technology in the field of multimedia analysis. Existing methods mainly focus on learning common embedding space images (or patches) and sentences words), whereby their mapping features such can be directly measured. Nevertheless, most existing image-text works rarely consider shared semantic concepts that potentially correlated heterogeneous modalities, which enhance discriminative power space. Toward this end, we propose a...
We used diffusion MRI and x-ray synchrotron imaging on monkey mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. compared structure corpus callosum crossing regions investigated differences cuprizone-induced experimental demyelination mouse versus healthy controls. Our findings revealed common principles two species; small axonal fasciculi major bundles formed laminar structures with varying angles, according characteristics pathways....