A5088325657- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Seaweed-derived Bioactive Compounds
- Metabolism, Diabetes, and Cancer
- Ginkgo biloba and Cashew Applications
- Lysosomal Storage Disorders Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Chinese Institute for Brain Research
2014
Capital Medical University
2013-2014
Summary Aims To explore the effect of fucoidan treatment on oxidative stress‐mediated dopaminergic neuronal damage and its potential mechanisms. Methods The was investigated in a 6‐hydroxydopamine (6‐OHDA) rat model PD, an animal considered appropriate for preclinical studies PD therapy. effects behavior survival ratio neurons were investigated. We further observed microglia NADPH oxidases‐1 (Nox1), family enzymes generating reactive oxygen species ( ROS ). Results found that chronic...
Summary Background and aims Tenuigenin (Ten) is a Chinese herbal extract with antioxidative antiinflammatory effects on toxin‐induced cell models of Parkinson's disease (PD); however, its α‐synuclein toxicity‐based PD remain unknown. hyperphosphorylation key event in pathogenesis potential target therapeutic interventions. We tested whether Ten alleviates α‐synuclein‐induced cytotoxicity via reducing kinases that phosphorylate α‐synuclein. Methods SH‐SY5Y cells transiently transfected...