A5100755109- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Natural Compounds in Disease Treatment
- Tryptophan and brain disorders
- Phagocytosis and Immune Regulation
- Biochemical Acid Research Studies
- RNA Interference and Gene Delivery
- Seaweed-derived Bioactive Compounds
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Apelin-related biomedical research
- RNA regulation and disease
- Cholinesterase and Neurodegenerative Diseases
- Tissue Engineering and Regenerative Medicine
- Receptor Mechanisms and Signaling
- Lysosomal Storage Disorders Research
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- Advanced biosensing and bioanalysis techniques
- Axon Guidance and Neuronal Signaling
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
Peking University
2021-2025
Peking University Third Hospital
2021-2025
Capital Medical University
2014-2024
Beijing Ditan Hospital
2024
Shenzhen University Health Science Center
2024
Capital University
2022-2023
Tianjin University
2023
Jinan Central Hospital
2023
Shandong First Medical University
2023
Shandong University
2023
Abstract Background Emerging evidence indicates that inflammasome-induced inflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Several proteins including α-synuclein trigger activation NLRP3 inflammasome. However, few studies examined whether inflammasomes are activated periphery PD patients and their possible value diagnosis or tracking progress PD. The aim this study was to determine association between clinical features Methods There were total 67...
Epigenetic dysregulation, which leads to the alteration of gene expression in brain, is suggested as one key pathophysiological bases ageing and neurodegeneration. Here we found that, late-stage familial Alzheimer's disease (FAD) mouse model, repressive histone H3 dimethylation at lysine 9 (H3K9me2) euchromatic methyltransferases EHMT1 EHMT2 were significantly elevated prefrontal cortex, a cognitive region affected disease. Elevated levels H3K9me2 also detected cortex post-mortem tissues...
Emerging evidence indicates that nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Thus, inhibition NLRP3 inflammasome activation may offer therapeutic benefit treatment PD. Tenuigenin, major active component Polygala tenuifolia, has been shown to have potential anti-inflammatory activity, but underlying mechanisms remain obscure.In present study,...
The α-synuclein aggregates are the main component of Lewy bodies in Parkinson's disease (PD) brain, and they showed immunotherapy could be employed to alleviate aggregate pathology PD. Recently we have generated DNA aptamers that specifically recognize α-synuclein. In this study, further investigated vivo effect these on neuropathological deficits associated with For efficient delivery into mouse modified exosomes neuron-specific rabies viral glycoprotein (RVG) peptide membrane surface. We...
The mitochondrion is susceptible to neurodegenerative disorders such as Parkinson's disease (PD). Mitochondrial dysfunction has been considered play an important role in the dopaminergic degeneration PD. However, there are no effective drugs protect mitochondria from during development. In present study, fucoidan, a sulfated polysaccharide derived Laminaria japonica, was investigated and characterized for its protective effect on dopamine system mitochondrial function of neurons...
TAM tyrosine kinases play multiple functional roles, including regulation of the target genes important in homeostatic cytokine receptors or TLR-mediated signal transduction pathways. In this study, we show that affect adult hippocampal neurogenesis and loss impairs neurogenesis, largely attributed to exaggerated inflammatory responses by microglia characterized increased MAPK NF-κB activation elevated production proinflammatory cytokines are detrimental neuron stem cell proliferation...
Abstract Accumulation of amyloid β (Aβ) peptide, inflammation, and oxidative stress contribute to Alzheimer's disease (AD) trigger complex pathogenesis. The ketone body β‐hydroxybutyrate (BHBA) is an endogenous metabolic intermediate that protects against stroke neurodegenerative diseases, but the underlying mechanisms are unclear. present study aims elucidate protective effects BHBA in early stage AD model investigate molecular mechanisms. Three‐and‐half‐month‐old double‐transgenic mice...
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate pathogenesis and therapy PD. However, behavior associated pathological features long term have not previously described dynamically. In present study, was established by 6‑OHDA injection in striatum. The PD determined 2 weeks following surgery, according apomorphine (APO)‑induced rotations, cylinder, rotarod open field...
Parkinson's disease (PD) is one of the most prevalent forms synucleinopathies, and it characterized neuropathologically by presence intracellular inclusions composed primarily protein α-synuclein (α-syn) in neurons. The previous immunotherapy targeting α-syn PD models with monoclonal antibodies has established as an effective target for neuronal cell death. However, due to essential weaknesses antibody unique features aptamers, aptamers could represent a promising alternative currently used...
Abstract Background Neuronal hyperactivity related to β-amyloid (Aβ) is considered an early warning sign of Alzheimer disease (AD). Although increasing evidence supports this opinion, the underlying mechanisms are still unknown. Methods Here, we recorded whole-cell synaptic currents and membrane potentials using patch clamping acute hippocampal slices from human amyloid precursor protein (APP)/presenilin-1 transgenic (5XFAD) mice their wild-type littermates. Biochemical methods, electron...
The complex pathogenesis of Alzheimer’s disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic strategies for AD are still urgently needed. Triptolide is the major active compound extracted from Tripterygium wilfordii Hook.f., a traditional Chinese medicinal herb that commonly used to treat inflammatory diseases. 5-month-old 5XFAD mice, which carry five familial mutations in β-amyloid...
Summary Aims To explore the effect of fucoidan treatment on oxidative stress‐mediated dopaminergic neuronal damage and its potential mechanisms. Methods The was investigated in a 6‐hydroxydopamine (6‐OHDA) rat model PD, an animal considered appropriate for preclinical studies PD therapy. effects behavior survival ratio neurons were investigated. We further observed microglia NADPH oxidases‐1 (Nox1), family enzymes generating reactive oxygen species ( ROS ). Results found that chronic...
The abnormal amyloid β (Aβ) accumulation and Aβ-related neural network dysfunction are considered central to the pathogenesis of Alzheimer's disease (AD) at early stage. Deep-brain reachable low field magnetic stimulation (DMS), a novel noninvasive approach that was designed intervene activity in brains, has been found alleviate stress-related cognitive impairments.Amyloid precursor protein/presenilin-1 transgenic mice (5XFAD) were treated with DMS, behavior AD-like pathologic changes...
Summary Background Microglia‐mediated inflammation may play an important role in the pathophysiology progression of neurodegenerative diseases, such as Parkinson's disease ( PD ), but molecular mechanisms are poorly understood. Aims This study sought to determine whether E3 ubiquitin ligase c‐Cbl plays a brain and explore relevant mechanism. Methods After BV 2 microglial cells c‐Cbl‐deficient mice were treated with lipopolysaccharide LPS neuroinflammation activation evaluated by...
Objective: This study aimed to conduct a bibliometric analysis of the literature on exoskeleton robot assisted walking rehabilitation for stroke patients in Web Science Core Collection over past decade. Method: Retrieved gait training hemiplegic from 1 January 2014 31 2024. The search method was topic search, and types documents were “article, meeting abstract, review article, early access.” CiteSpace used analyze results countries, institutions, keywords, cited references authors. Result: A...
Alzheimer's disease (AD) is characterized by progressive decline of memory and cognitive functions. Deep magnetic stimulation (DMS), a noninvasive nonpharmacological brain stimulation, has been reported to alleviate stress-related impairment in neuropsychiatric disorders. Our previous study also discovered the preventive effect DMS on an AD mouse model. However, underlying mechanism must be explored further. In this study, we investigated spatial learning functions, neurogenesis dentate...
Alzheimer's disease (AD) is the most prevalent neurodegenerative characterized by aggregation of amyloid-β (Aβ) peptide in hippocampus and cortex brain. Neuroinflammation considered a driving force progression cognitive decline AD. During neuroinflammatory process, activated astrocytes microglia induced Aβ produce pro-inflammatory factors neurotoxins, which promote neurodegeneration AD brain, eventually dementia. Thus, suppression glial over-activation brain might result therapeutic effect....
Summary Background P arkinson's disease ( PD ) is a neurodegenerative disorder characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta SN pc). Aims To study if tenuigenin TEN ), main active component olygala tenuifolia , can protect from inflammation‐mediated damage vivo . Methods We observed effects on lipopolysaccharide LPS induced model behavioral analysis, high‐performance liquid chromatography, immunohistochemistry and enzyme‐linked...