A5048549659- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Trigeminal Neuralgia and Treatments
- Mitochondrial Function and Pathology
- Autism Spectrum Disorder Research
- Ginkgo biloba and Cashew Applications
- Lysosomal Storage Disorders Research
- Facial Nerve Paralysis Treatment and Research
- Sleep and Wakefulness Research
- Neurological and metabolic disorders
- Glycogen Storage Diseases and Myoclonus
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- CRISPR and Genetic Engineering
- Hereditary Neurological Disorders
- Genomic variations and chromosomal abnormalities
- Neuroinflammation and Neurodegeneration Mechanisms
National Neuroscience Institute
2016-2025
Singapore General Hospital
2016-2025
Duke-NUS Medical School
2016-2025
National University of Singapore
2016-2025
Nankai University
2024
Hunan University
2024
Anhui Agricultural University
2024
Zhejiang University
2024
Mudanjiang Medical University
2024
Nanyang Technological University
2023-2024
Background and purpose Non‐motor symptoms ( NMS s) are common amongst patients with Parkinson's disease PD ); however, little is known about their influence on the health‐related quality of life (QoL) over a defined follow‐up period. The study was aimed to establish impact s QoL 2‐year Method A total 227 newly referred were prospectively recruited between 2013 2014. Non‐Motor Symptoms Scale used evaluate burden whilst assessed Disease Questionnaire‐39 items. Motor disabilities using Part III...
Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies performed in just one population at a time. Here we large-scale multi-ancestry meta-analysis of with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals European, East Asian, Latin American African ancestry. In meta-analysis, 78 significant loci, 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2,...
Abstract In face‐to‐face interviews, we examined 157 consecutive individuals aged 55 years and older, selected from the general population in Singapore, 1,000 21 a primary healthcare center. Based on IRLSSG criteria, prevalence of restless leg syndrome (RLS) was 0.6% 0.1%, respectively.
To study the safety and efficacy of botulinum toxin A (BTX) in patients with oromandibular dystonia (OMD) to compare treatment results various subtypes OMD.OMD is one most challenging forms treat. Pharmacologic therapies are generally not effective, there no surgical alternatives.Of 202 diagnosed clinically have OMD a movement disorders clinic over period 10 years, 162 satisfied inclusion criteria. The masseters submentalis complex were only two muscle groups injected BTX this group...
Data from Asian populations on dietary and lifestyle factors associated with Parkinson's disease are sparse. In 1993–2005, the authors examined these in relation to Singapore Chinese Health Study, a prospective cohort of 63,257 men women. Baseline data were collected through in-person interviews using structured questionnaires. All 157 incident cases identified either follow-up or via linkage hospital discharge databases outpatient registries confirmed by review medical records. Current...
Scope The accumulation of misfolded α‐synuclein in dopaminergic neurons is the leading cause Parkinson's disease (PD). Resveratrol (RV), a polyphenolic compound derived from grapes and red wine, exerts wide range beneficial effects via activation sirtuin 1 (SIRT1) induction vitagenes. Here, we assessed role RV 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP) induced mouse model PD explored its potential mechanisms. Methods results EX527, specific inhibitor SIRT1, were administered...
Background The relationship between a number of primary sleep disorders and Parkinson's disease (PD) is still debated. There are limited case control polysomnographic studies in PD most these study sample sizes small. Methodology/Findings We conducted one the largest case-control involving overnight evaluation, with prospective recruitment unselected patients healthy controls from an Asian population. cases were recruited specialized movement disorder outpatient clinics tertiary referral...
Genome-wide association studies (GWAS) on Parkinson's disease (PD) have mostly been done in Europeans and Japanese. No study has Han Chinese, which make up nearly a fifth of the world population. We conducted first Chinese GWAS analysing total 22,729 subjects (5,125 PD cases 17,604 controls) from Singapore, Hong Kong, Malaysia, Korea, mainland China Taiwan. performed imputation, merging logistic regression analyses 2,402,394 SNPs passing quality control filters 779 cases, 13,227 controls,...
Abstract Reactive oxygen species (ROS) and mitophagy are profoundly implicated in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Several studies have suggested that ROS not involved mitochondrial translocation Parkin which primes mitochondria for autophagic elimination. However, whether play a role execution is unknown. In present study, we show carbonyl cyanide m -chlorophenylhydrazone (CCCP) treatment induced both depolarization generation were needed...
Background and purpose The aim of this study was to examine non‐motor symptoms in different Parkinson's disease ( PD ) motor subtypes their associations with quality life (QoL). Methods A total 132 patients early comprehensive examinations symptom assessments were included. Motor classified based on Stebbins’ method. Non‐motor assessed by the Non‐Motor Symptom Scale NMSS validated more instruments, including Pittsburgh Sleep Quality Index PSQI Fatigue Severity FSS ). QoL measured Disease...
The presence of Notch homolog 2 N-terminal-like C (NOTCH2NLC) repeat expansions are associated with neuronal intranuclear inclusion body disease (NIID), varied neurological signs, including neuropathy, ataxia, parkinsonism, and tremor. To date, genetic screening NOTCH2NLC GGC repeats in a cohort typical Parkinson (PD) appears not to have been reported.To investigate if present patients PD controls.This case-control study was conducted tertiary movement disorder centers Singapore....
We utilized human midbrain-like organoids (hMLOs) generated from pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parkinson disease, with the particular aim of recapitulating α-syn- Lewy body-related pathologies process neurodegeneration hMLO model.We characterized hMLOs GBA1-/- SNCA overexpressing isogenic embryonic also body-like inclusions GBA1/SNCA dual perturbation...