A5054250975- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Ginkgo biloba and Cashew Applications
- RNA regulation and disease
- Health Systems, Economic Evaluations, Quality of Life
- Balance, Gait, and Falls Prevention
- Lysosomal Storage Disorders Research
- Nuclear Receptors and Signaling
- Neurological diseases and metabolism
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Restless Legs Syndrome Research
- Genetic Neurodegenerative Diseases
- Dysphagia Assessment and Management
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Organ Donation and Transplantation
- Genetic Associations and Epidemiology
- Alzheimer's disease research and treatments
- RNA and protein synthesis mechanisms
- Genetics and Neurodevelopmental Disorders
- Cellular transport and secretion
- Banana Cultivation and Research
- Autism Spectrum Disorder Research
National Neuroscience Institute
2015-2025
Duke-NUS Medical School
2011-2024
National University of Singapore
2009-2024
Molecular Biology Consortium
2023
Singapore General Hospital
2009-2021
Genome Institute of Singapore
2010-2013
Chang Gung University
2013
Chang Gung Memorial Hospital
2013
Sun Yat-sen University
2013
Agency for Science, Technology and Research
2010-2013
Data from Asian populations on dietary and lifestyle factors associated with Parkinson's disease are sparse. In 1993–2005, the authors examined these in relation to Singapore Chinese Health Study, a prospective cohort of 63,257 men women. Baseline data were collected through in-person interviews using structured questionnaires. All 157 incident cases identified either follow-up or via linkage hospital discharge databases outpatient registries confirmed by review medical records. Current...
Genome-wide association studies (GWAS) on Parkinson's disease (PD) have mostly been done in Europeans and Japanese. No study has Han Chinese, which make up nearly a fifth of the world population. We conducted first Chinese GWAS analysing total 22,729 subjects (5,125 PD cases 17,604 controls) from Singapore, Hong Kong, Malaysia, Korea, mainland China Taiwan. performed imputation, merging logistic regression analyses 2,402,394 SNPs passing quality control filters 779 cases, 13,227 controls,...
Background and purpose The aim of this study was to examine non‐motor symptoms in different Parkinson's disease ( PD ) motor subtypes their associations with quality life (QoL). Methods A total 132 patients early comprehensive examinations symptom assessments were included. Motor classified based on Stebbins’ method. Non‐motor assessed by the Non‐Motor Symptom Scale NMSS validated more instruments, including Pittsburgh Sleep Quality Index PSQI Fatigue Severity FSS ). QoL measured Disease...
We and others found two polymorphic LRRK2 (leucine-rich repeat kinase 2) variants (rs34778348:G>A; p.G2385R rs33949390:G>C; p.R1628P) associated with Parkinson disease (PD) among Chinese patients, but the common worldwide rs34637584:G>A; p.G2019S mutation, was absent. Focusing exclusively on Han Chinese, we first sequenced coding regions in young onset familial PD patients identified 59 variants. then examined these 250 control subjects. Among 17 variants, five demonstrated different...
Background and purpose There have been few long‐term studies that characterized charted the clinical progression of Parkinson's disease ( PD ). This study was therefore undertaken to understand natural evolution treated patients identify variables predict greater in these patients. Methods A longitudinal linear mixed model analysis motor score performed on 576 derived from National Neuroscience Institute Movement Disorders Database. Clinical demographic were taken at baseline formed...
<h3>Background and objectives</h3> The neuroanatomical substrates underlying cognitive impairment in Parkinson9s disease (PD) remain poorly understood. To address this gap, we compared the grey matter atrophy patterns PD patients with mild (PD-MCI) having no (PD-NCI), examined relationships between atrophic regions performance specific domains. <h3>Methods</h3> 90 non-demented (64.95±7.54 years, Hoehn Yahr=1.88±0.39) were classified using formal diagnostic criteria as PD-MCI (n=23) or PD-NCI...
<b>Objective:</b> A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on <i>1q32 (PARK16)</i> (OMIM 613164) and <i>BST1</i>. We analyzed single nucleotide polymorphism (SNPs) located at GWAS-linked (<i>PARK16, PARK8, PARK1</i>, <i>BST1</i>) a Chinese also conducted meta-analysis Asians by pooling independent replication studies from Japan. <b>Methods:</b> an analysis of 13 SNPs associated with PD case-control cohorts...
Mild cognitive impairment (MCI) is associated with pronounced grey matter atrophy in various brain regions. However, the association between patterns and progression from no (NCI) to Parkinson's disease (PD)-MCI not clearly known. We investigated pattern of subcortical structures its impact on cognition patients mild PD.Sixty-five PD baseline longitudinal clinical neuropsychological assessments, structural magnetic resonance imaging scans were studied. Movement Disorder Society Task Force...
West Nile virus (WNV) is a re-emerging pathogen responsible for outbreaks of fatal meningoencephalitis in humans. Previous studies have suggested protective role monocytes mouse model WNV infection, but the molecular mechanisms remained unclear. In this study, we show that genetic deficiency Ccr2, chemokine receptor on Ly6c<sup>hi</sup> inflammatory and other leukocyte subtypes, markedly increases mortality due to encephalitis C57BL/6 mice; was associated with large selective reduction...
This study quantified the total brain and periventricular white matter hyperintensity (WMH) burdens in patients with early Parkinson's disease (PD) explored their associations cardiovascular risk factors cognitive performance.A of 175 non-demented PD who had undergone baseline magnetic resonance imaging were included. Comprehensive neurocognitive testing was conducted to identify mild impairment (PD-MCI) evaluate performances individual domains. Cardiovascular expressed as a modified...
The biological underpinnings of the PD clusters remain unknown as existing lacks biomarker characterization. We try to identify clinical subtypes Parkinson Disease (PD) in an Asian cohort and characterize them by comparing assessments, genetic status blood biochemical markers. A total 206 patients were included from a multi-centre cohort. Hierarchical clustering was performed generate subtypes. Clinical characterization allelic distributions related gene (SNCA, LRRK2, Park16, ITPKB, SV2C)...
A broad list of variables associated with mild cognitive impairment (MCI) in Parkinson disease (PD) have been investigated separately. However, there is as yet no study including all them to assess variable importance. Shapley importance cloud (ShapleyVIC) can robustly while accounting for correlation between variables. Objectives this were (i) prioritize the important PD-MCI and (ii) explore new blood biomarkers related PD-MCI.ShapleyVIC-assisted selection was used identify a subset from 41...
Abstract It has been reported that patients on pergolide and carbergoline have an increased risk of developing valvular heart disease. is uncertain if bromocriptine, ergot‐derived dopamine agonist (DA) with partial 5‐HT 2B activity, associated a similar risk. We assessed the frequency disease in Parkinson's (PD) bromocriptine compared to control group PD who had not treated any DA. Seventy‐two 21 pergolide, 47 were recruited. Transthoracic echocardiographic studies performed reviewed by...
Background and purpose: This cross‐sectional study was carried out to identify factors predicting health‐related quality of life (HRQoL) amongst Asian patients with Parkinson’s disease (PD). Methods: A total 183 PD (mean age: 61 years, male: 68.9%) attending a tertiary neuroscience clinic in Singapore completed the English or Chinese version 8‐item Disease Questionnaire (PDQ‐8). Patients’ socio‐demographic characteristics their clinical variables were analysed influencing PDQ‐8 Summary Index...
Guidelines for medical management are now part of life. A fool - loosely defined as someone who does not know much about a particular area medicine will do well to follow guidelines when treating patients, but wise man (again, the disease in question) might better them slavishly. The problem is that evidence on which based seldom very good. Clinical trials have variety problems often make their relevance 'real world' dubious. interpretation trial results depends heavily opinion, and...
Background: Lipid biomarkers have potential neuroprotective effects in Parkinson’s disease (PD) and there is limited evidence the field. Objective: This study aims to investigate association between comprehensive blood lipid PD. Methods: A total of 205 PD patients 102 non-PD subjects were included from Early Longitudinal Singapore (PALS) cohort. We investigated 6 serum including cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), apolipoprotein A1 (Apo A1), low-density...
Genome-wide association studies have identified SV2C as a Parkinson's disease (PD) risk locus, with common missense variant p.Asp543Asn in the synaptic vesicle glycoprotein 2C (SV2C) protein significantly associated PD. We examined if other rare variants also influence PD risk. analyzed sequencing data of 9810 East Asian individuals comprising 4298 patients and 5512 controls 55 nonsynonymous variants. There was no significant or loss-of-function Our findings show that besides p.Asp543Asn,...
This study was carried out to evaluate the economic burden of Parkinson's disease (PD) and factors independently associated with individual components total cost in Singapore.A consecutive sample 195 patients PD (mean age: 68.2, men: 51.8%) attending a tertiary neuroscience clinic were identified interviewed using standardized questionnaires including financial questionnaire, two Health Related Quality Life (HRQoL) Beck Depression Inventory questionnaire.Annual from societal perspective...