A5041235214- Trauma and Emergency Care Studies
- Parkinson's Disease Mechanisms and Treatments
- Emergency and Acute Care Studies
- Palliative Care and End-of-Life Issues
- Hip and Femur Fractures
- Asthma and respiratory diseases
- Obesity, Physical Activity, Diet
- Frailty in Older Adults
- Behavioral Health and Interventions
- Injury Epidemiology and Prevention
- Ophthalmology and Visual Impairment Studies
- Neurological disorders and treatments
- Family Support in Illness
- Restless Legs Syndrome Research
- Dementia and Cognitive Impairment Research
- Glaucoma and retinal disorders
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Corneal surgery and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Cystic Fibrosis Research Advances
- Eating Disorders and Behaviors
- Inflammatory Bowel Disease
- Patient Dignity and Privacy
- Respiratory viral infections research
Duke-NUS Medical School
2014-2022
National University of Singapore
2015-2019
Singapore General Hospital
2018-2019
Changi General Hospital
2019
Ministry of Health of the Russian Federation
2019
KK Women's and Children's Hospital
2019
University of Wisconsin–Madison
2005-2009
Background and purpose Non‐motor symptoms ( NMS s) are common amongst patients with Parkinson's disease PD ); however, little is known about their influence on the health‐related quality of life (QoL) over a defined follow‐up period. The study was aimed to establish impact s QoL 2‐year Method A total 227 newly referred were prospectively recruited between 2013 2014. Non‐Motor Symptoms Scale used evaluate burden whilst assessed Disease Questionnaire‐39 items. Motor disabilities using Part III...
Understanding goals of care for terminally ill patients at the end life is crucial to ensure that receive consistent with their preferences.
Abstract Immunotherapy for malignant gliomas is being studied as a possible adjunctive therapy this highly fatal disease. Thus far, inadequate understanding of brain tumor immunology has hindered the design such therapies. For instance, role microglia and macrophages, which comprise significant proportion tumor‐infiltrating inflammatory cells, in regulation local anti‐tumor immune response poorly understood. To study macrophages to known activators tumors, we injected CpG...
Abstract Background Frailty has been associated with an increased risk of adverse postoperative outcomes in elderly patients. We examined the impact preoperative frailty on loss functional independence following emergency abdominal surgery elderly. Methods This prospective cohort study was performed at a tertiary hospital, enrolling patients 65 years age and above who underwent from June 2016 to February 2018. Premorbid variables, perioperative characteristics were collected. Two measures...
Background Frailty is associated with adverse outcomes including disability, mortality and risk of falls. Trauma registries capture a broad range injuries. However, frail patients who fall comprise large proportion the injuries occurring in ageing populations are likely to have different compared non-frail injured patients. The effect fallers on under-explored but potentially significant. Currently, many trauma define low falls as less than three metres, height that include non-frailty We...
Anatomy-based injury severity scores are commonly used with physiological for reporting of in a standardized manner. However, there is lack consensus on choice scoring system, the score (ISS) performing poorly certain sub-groups, eg head-injured patients. We hypothesized that adding dichotomous variable polytrauma (yes/no Abbreviated Injury Scale (AIS) 3 or more at least two body regions) to New Severity Score (NISS) would improve prediction in-hospital mortality injured patients, including...
Introduction: This study aims to assess the correlation of age-adjusted Charlson comorbidity index (ACCI) with 5-year mortality in a surgically treated hip fracture population. Materials and Methods: A retrospective analysis was performed on 1057 patients aged 60 years above who underwent surgery for minimum follow-up (92.2% rate) tertiary hospital. Manual review patients’ electronic hospital records record demographic data, comorbidities, length stay. Mortality data were extracted from...
Abstract We hypothesized that deterministic tractography is practical and sensitive to changes in the complex nigrostriatal nigropallidal pathway (NSP) Parkinson’s disease (PD). Using diffusion tensor imaging (DTI) tractography, we investigated NSP evaluate differences between PD patients controls examined their clinico-radiologic correlation. Structural DTI brain scans were obtained 40 subjects (21 19 healthy controls). isolated using a user-friendly toolkit based on brute-force...
Personal mobility devices (PMDs) like skate-scooters, electric bicycles (e-bikes) or motorised scooters (e-scooters) have become widely available globally. There are several studies describing the rising incidence of injury from such devices. The aim our study was to examine PMD user factors between (MotPMDs) vs non-motorised PMDs (NonPMDs) as risk for severe and need hospital admission.We analysed de-identified National Trauma Registry data (2015 2017) all public sector hospitals in...
The underlying causes of presbyopia, and the functional relationship between ciliary muscle lens during aging are unclear. In current study, these relationships were studied in rhesus monkeys, whose accommodative apparatus age-related loss accommodation similar to those humans.Centripetal body equator movements measured 28 eyes 21 monkeys (ages, 5.7-26 years) by goniovideography. Ultrasound biomicroscopy was performed 17 monkeys. Narrowing angle anterior aspect inner cornea used as a...
Advanced cancer significantly impacts quality of life patients and families as they cope with symptom burden, treatment decision-making, uncertainty costs treatment. In Singapore, information about the experiences advanced financial cost incur for end-of-life care is lacking. Understanding this needed to inform practice policy ensure continuity affordability at end life. The primary objectives Cost Medical Care Patients Serious Illness in Singapore (COMPASS) cohort study are describe changes...
Asthma control can be assessed with the Control Test (ACT) and a score of 20 or higher indicates good asthma control. Patients pay for their consultation treatment in fee-for-service primary healthcare system Singapore. We hypothesized that achieving would result lower costs through reduced acute exacerbations, fewer physician consultations lost productivity. The study compared patients who achieved those suboptimal based on ACT scores. Factors influencing expenditure over time were also...
Bronchoalveolar lavage (BAL) is utilized for diagnosing lung infiltrates in immunocompromised. There heterogeneity the data and reported diagnostic yields range from 26 to 69%. Therefore, selection criteria BAL maximize yield minimize complications are unclear. Objectives of this study were determine complication rate immunocompromised patients presenting with infiltrates, identify factors impacting these outcomes. Exploratory aims included characterization pathogens, treatment modification...
To document zonular orientation and suspension of the lens during accommodation, age-related changes circumlental space (CLS) at rest in living iridectomized rhesus monkey eyes.The CLS was measured 34 eyes 24 monkeys, age 5.7 to 26 years, resting accommodated state, zonula accommodation assessed qualitatively.The nonaccommodated decreased significantly with both nasal temporal quadrants tended do so a slightly faster rate quadrant. The correlated accommodative amplitude: greater amplitude....
Socioeconomic status affects survival in patients diagnosed with head and neck squamous cell carcinoma (HNSCC), even health systems universal care. Singapore has a tiered subsidized housing system, which income determines eligibility for subsidies by size of apartment. The objective this study was to assess whether patient's residential type (small/heavily subsidized, medium/moderate subsidy, large/minimal or no subsidy) influenced mortality. A secondary analysis examined smaller apartments...
Research on asthma costs often focuses estimating average costs. Trends in and patterns of medication use, especially for those who have been followed up under treatment, received much less attention. This study's objective was to document over time patients are enrolled an care programme Singapore identify its predictors, using a 10-year longitudinal dataset.The study population comprised different cohorts 939 entering the at times during 2004-2013. Average were estimated trends examined...
Introduction: Given the complex multitude of Parkinson's disease (PD) symptoms, caregiving for PD patients can be highly demanding. Our study was aimed to investigate characteristics related different levels caregiver burden. Methods: This cross-sectional recruited 104 idiopathic patient-caregiver pairs. Patients were evaluated on motor, non-motor and quality life (QoL). Caregiver burden quantified using Zarit Burden Inventory subsequently stratified into 3 subgroups. Statistical analysis...
Survivors of trauma are at increased risk dying after discharge. Studies have found that age, head injury, injury severity, falls and co-morbidities predict long-term mortality. The objective our study was to build a nomogram predictor 1-year 3-year mortality for major blunt adult survivors the index hospitalization. Using data from Singapore National Trauma Registry, 2011–2013, we analyzed adults aged 18 over, admitted with an severity score (ISS) 12 or more, who survived hospitalization,...