A5080281123- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Transcranial Magnetic Stimulation Studies
- Pancreatic and Hepatic Oncology Research
- Neuroscience and Neural Engineering
- Soft Robotics and Applications
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
- Pancreatitis Pathology and Treatment
- Trauma and Emergency Care Studies
- Vascular Malformations Diagnosis and Treatment
- Muscle activation and electromyography studies
- Genetic Neurodegenerative Diseases
- EEG and Brain-Computer Interfaces
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cerebrospinal fluid and hydrocephalus
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Analysis
National Neuroscience Institute
2012-2022
Duke-NUS Medical School
2017-2022
National University of Singapore
2018-2021
Singapore General Hospital
2014-2020
Singapore College of Traditional Chinese Medicine
2020
Mount Elizabeth Hospital
2020
Medpace (United States)
2020
Northwestern University
2019
SingHealth Duke-NUS Academic Medical Centre
2017
Toronto Western Hospital
2015-2017
Although there is considerable interest in the use of bone morphogenetic protein (BMP) to promote periodontal regeneration, little known its effects on early stages wound healing. The aim this study was investigate recombinant human 2 (rhBMP-2) an stage post-operative healing and following complete (10 38 days, respectively) a rat model regeneration. buccal aspects molar roots were carefully denuded their ligament through bony window created mandibles Wistar rats under general anesthesia....
ABSTRACT Background The ventral intermediate nucleus of the thalamus is not readily visible on structural magnetic resonance imaging. Therefore, a method for its visualization stereotactic targeting desirable. Objective objective this study was to define tractography‐based methodology nucleus. Methods lateral and posterior borders were defined by tracking pyramidal tract medial lemniscus, respectively. A thalamic seed then created 3 mm anterior these borders, connections analyzed....
Anterior nucleus (AN) deep brain stimulation (DBS) is a palliative treatment for medically refractory epilepsy. The long-term efficacy and the optimal target localization AN DBS are not well understood.To analyze of its predictors.We performed retrospective review 16 patients who underwent DBS. We selected only with reliable seizure frequency data at least 1-year follow-up. studied duration reduction after insertion before (the insertional effect) association outcome. modeled volume...
An accurate prognostic model is extremely important in severe traumatic brain injury (TBI) for both patient management and research. Clinical prediction models must be validated internally externally before they are considered widely applicable. Our aim to independently validate two models, one developed by the Corticosteroid Randomization After Significant Head (CRASH) trial investigators, other from International Mission Prognosis Analysis of Trials Traumatic Brain Injury (IMPACT) group....
Chronic subdural hemorrhage (SDH) or hematoma is a condition that affects elderly individuals. With advances in medical care, the number of nonagenarians and centenarians will increase. However, surgical treatments this age group are associated with high rates morbidity mortality. Because no data available on survival among patients chronic SDHs who undergo drainage receive only conservative goal study was to determine 90 years older symptomatic SDHs.The authors conducted retrospective...
OBJECTIVE The ventral intermediate nucleus (VIM) of the thalamus is not visible on structural MRI. Therefore, direct VIM targeting methods for stereotactic tremor surgery are desirable. authors previously described a method visualizing and its connectivity using deterministic tractography. In this combined electrophysiology imaging study, investigated within tractography-defined (T-VIM). METHODS Thalamic neurons were classified based their relative location to T-VIM: dorsal, within, T-VIM....
Intracerebral hemorrhage (ICH) accounts for 10-15% of all first time strokes and with incidence twice as high in the Asian compared to Western population. This study aims investigate gender differences ICH patient outcomes a multi-ethnic population.Data 1,192 patients admitted were collected over four-year period. Multivariate logistic regression was used identify independent predictors odds ratios computed 30-day mortality Glasgow Outcome Scale (GOS) comparing males females.Males suffered...
There is a well-recognised association between hyperlipidaemia and acute pancreatitis. However, the role of in modulating disease course not clear. The aim study was to conduct prospective pancreatitis assess relation severity using current descriptors. population constituted 43 patients with pancreatitis, admitted during calendar year 2001. were 19 (44%) males. median (range) age 50 (21-86) years. Serum triglycerides, cholesterol high-density lipids measured on admission. Patients...
We report the development and implementation of an epi-detected spectral-focusing hyperspectral stimulated Raman scattering (SRS) imaging technique for label-free biomolecular subtyping glioblastomas (GBMs). The SRS developed generates image stacks (from 2800 to 3020 cm–1 at 7 intervals) within 30 s through controlling time delay between chirped pump Stokes beams. images representative shifts (e.g., 2845, 2885, 2935 cm–1) delineate biochemical variations morphological differences proneural...
This paper presents a disposable fiber Bragg grating (FBG) based tridirectional force/torque sensor mountable at the end of tip aspiration instruments for detecting instrument-tissue interaction force/torque. The utilizes an inexpensive three-dimensional (3-D) printed elastomer with annular diaphragm, which is sensitive to axial force (Fz) and torques (Mx My). Four suspended optical fibers inscribed FBG each have been fixed on two ends simultaneously sense decouple force/torque-induced...
The choice of programmable or nonprogrammable shunts for the management hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH) remains undefined. Variable intracranial pressures make optimal difficult. Programmable have been shown to reduce problems with drainage, but at 3 times cost shunts.All patients who underwent insertion a ventriculoperitoneal shunt SAH between 2006 and 2012 were included. Patients divided into those in whom inserted. rates revisions, reasons adjustments settings...
Dexmedetomidine (an alpha-2 adrenergic agonist) sedation is commonly used during subthalamic nucleus (STN) deep-brain stimulation (DBS). Its effects on the electrophysiological characteristics of human STN neurons are largely unknown. We hypothesised that dexmedetomidine modulates firing rates and bursting neurons. analysed microelectrode recording (MER) data from patients with Parkinson's disease who underwent DBS. A 'Dex bolus' group (dexmedetomidine bolus prior to MER; 27 cells seven...
Cathodal-transcranial direct current stimulation induces therapeutic effects in animal ischemia models by preventing the expansion of ischemic injury during hyperacute phase ischemia. However, its efficacy is limited an accompanying decrease cerebral blood flow. On other hand, peripheral sensory can increase flow to specific brain areas resulting rescue neurovascular functions from damage. Therefore, two modalities appear complement each form integrated treatment modality. Our results showed...