Justin T. Hsieh
A5042530911- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Olfactory and Sensory Function Studies
- Acute Ischemic Stroke Management
- Mosquito-borne diseases and control
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Animal Genetics and Reproduction
- Alzheimer's disease research and treatments
- Intracranial Aneurysms: Treatment and Complications
- Opioid Use Disorder Treatment
- Anesthesia and Pain Management
- S100 Proteins and Annexins
- CRISPR and Genetic Engineering
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Anomalies and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Pain Management and Opioid Use
- Vascular Malformations Diagnosis and Treatment
- RNA regulation and disease
- Mast cells and histamine
- melanin and skin pigmentation
- Spinal Hematomas and Complications
Singapore General Hospital
2024
National University of Singapore
2015-2020
Chonnam National University Hospital
2015
Duke University
2015
Johns Hopkins Medicine
2011
Johns Hopkins University
2011
Carnegie Institution for Science
1999
Department of Embryology
1999
Abstract Japanese encephalitis virus (JEV) is a leading cause of viral encephalitis. However, the mechanisms JEV penetration blood-brain-barrier (BBB) remain poorly understood. Mast cells (MCs) are granulated innate immune sentinels located perivascularly, including at BBB. Here we show that activates MCs, to release granule-associated proteases in vivo. MC-deficient mice display reduced BBB permeability during infection compared congenic wild-type (WT) mice, indicating enhanced vascular...
Jenny Hsieh, Jing Liu, Stephen A. Kostas, Chieh Chang, Paul W. Sternberg, and Andrew Fire Carnegie Institution of Washington, Department Embryology, Baltimore, Maryland 21210 USA; Johns Hopkins University, Biology Graduate Program, 21218 Division Howard Hughes Medical Institute, California Institute Technology, Pasadena, 91125 USA
Intracerebral hemorrhage (ICH) accounts for 10-15% of all first time strokes and with incidence twice as high in the Asian compared to Western population. This study aims investigate gender differences ICH patient outcomes a multi-ethnic population.Data 1,192 patients admitted were collected over four-year period. Multivariate logistic regression was used identify independent predictors odds ratios computed 30-day mortality Glasgow Outcome Scale (GOS) comparing males females.Males suffered...
In models of acute brain injury, progesterone improves recovery through several mechanisms including modulation neuroinflammation. Secondary injury from neuroinflammation is a potential therapeutic target after intracerebral hemorrhage (ICH). For translation as clinical ICH therapeutic, the present study sought to define efficacy exogenous administration in ICH-relevant experimental paradigms. Young and aged C57BL/6 male, female, ovariectomized (OVX) mice underwent left intrastriatal...
<b><i>Background:</i></b> Preclinical evidence suggests that progesterone improves recovery after intracerebral hemorrhage (ICH); however, gonadal hormones have sex-specific effects. Therefore, an experimental model of ICH was used to assess administration in male and female rats. <b><i>Methods:</i></b> induced Wistar rats via stereotactic intrastriatal injection clostridial collagenase (0.5 U). Animals were randomized receive vehicle or 8...
Abstract Background A carotid-cavernous fistula is an abnormal communication between the arteries and veins within cavernous sinus. While conservative management may be prudent in low risk cases, many patients require intervention endovascular embolization has evolved as preferred method of treatment. Embolization can performed via either transarterial or transvenous approach. One major challenge approach complex variable compartmentation sinus, which often requires use profile...
Introduction: Progesterone is known to improve recovery in traumatic and ischemic brain injury models. For potential translation, the present study sought define efficacy of exogenous progesterone administration murine models ICH. Methods: Young aged C57/Bl6 male, female, ovariectomized (OVX) mice underwent left intrastriatal collagenase (0.075U) or autologous whole blood (35ul) injection. Mice were randomized receive at pre-specified doses (4-16 mg/kg), administered SQ 2 5 hours after then...