A5086679939- Clinical Nutrition and Gastroenterology
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Nutrition and Health in Aging
- Electrolyte and hormonal disorders
- Heat shock proteins research
- Intensive Care Unit Cognitive Disorders
- Pneumonia and Respiratory Infections
- Adrenal Hormones and Disorders
- Vitamin C and Antioxidants Research
- Thermal Regulation in Medicine
- Diet and metabolism studies
- Bacterial Infections and Vaccines
- Renal function and acid-base balance
- Nosocomial Infections in ICU
- Emergency and Acute Care Studies
- Childhood Cancer Survivors' Quality of Life
- Antibiotics Pharmacokinetics and Efficacy
- Hormonal Regulation and Hypertension
- Organ Transplantation Techniques and Outcomes
- Infant Nutrition and Health
- Receptor Mechanisms and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
University of Crete
2016-2025
University Hospital of Heraklion
2015-2024
BioCruces Health research Institute
2021
Children's Hospital of Los Angeles
2021
Crete University Press
2019
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2011-2016
National Institutes of Health
2011-2016
Great Ormond Street Hospital
2015-2016
University College London
2015-2016
University of Ioannina
2016
(1) Respiratory distress and seizures developed in an 18-month-old boy following brief exposure to low-strength (17.6%) N,N-diethyl-m-toluamide (DEET). A review of the literature revealed 17 reports DEET-induced encephalopathy children. The objective this study was test hypothesis that potential toxicity DEET is high available repellents containing DEET, irrespective their strength, are not safe when applied children's skin. (2) Although a case report, we used features published children...
Objectives: To measure energy expenditure in critically ill children and compare it with the predicted by recommended formulas, relate measured to nutritional clinical indices. Design: A prospective, study. Setting: Tertiary care pediatric intensive unit a university children's hospital. Patients: total of 37 patients critical illness who were mechanically ventilated for ≥24 hrs studied. Interventions: None. Measurements Main Results: Chronic protein-energy malnutrition (CPEM) acute defined...
It is not known if cytokines, which are cell-derived mediators released during the host immune response to stress, affect metabolic stress critical illness. The aim of this prospective study was determine whether related inflammatory interleukin-6 (IL-6), 10 (IL-10), and other mediators' responses assess their relationships with different feeding patterns, nutritional markers, severity illness as assessed by Multiple Organ System Failure (MOSF), Pediatric Risk Mortality Score (PRISM),...
Traditionally, energy requirements have been calculated using predictive equations. These methods failed to calculate expenditure accurately. Routine indirect calorimetry has suggested, but this method is technically demanding and costly. This study aimed develop a new equation estimate for critically ill children.This prospective, observational on ventilated children included patients with an endotracheal tube leak of < 10% fractional inspired oxygen 60%. An measurement was performed...
The purposes of this study are to examine if the human glucocorticoid receptor (hGR) isoform-α mRNA and hGR protein expressions deficient in acute phase sepsis (S) compared systemic inflammatory response syndrome (SIRS) healthy subjects (H) evaluate hGRα alterations associated with cortisol changes they related (1) extracellular intracellular heat shock proteins (HSP) 72 90α; (2) ACTH, prolactin, interleukins (ILs); (3) outcome.Patients consecutively admitted a university hospital intensive...
OBJECTIVES: To describe mechanical ventilation management and factors associated with nonadherence to lung-protective principles in pediatric acute respiratory distress syndrome. DESIGN: A planned ancillary study a prospective international observational study. Mechanical (every 6 hr measurements) during syndrome days 0–3 was described compared Pediatric Acute Lung Injury Consensus Conference tidal volume recommendations (< 7 mL/kg children impaired system compliance, < 9 all other...
Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis. This multicenter prospective observational study was designed to ascertain whether an oxidant/antioxidant imbalance independent sepsis discriminator mortality predictor intensive care unit (ICU) patients with (n = 145), compared non-infectious critically ill 112) healthy individuals 89). Serum total oxidative...
Abstract Background Critical illness constitutes a serious derangement of metabolism. The aim our study was to compare acute phase metabolic patterns in children with sepsis (S) or severe sepsis/septic shock (SS) those traumatic brain injury (TBI) and healthy controls (C) evaluate their relations neutrophil, lymphocyte monocyte expressions CD64 CD11b. Methods Sixty were enrolled the study. Forty-five systemic inflammatory response syndrome (SIRS) classified into three groups: TBI (n = 15), S...
Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared healthy children (H); we assessed relation (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic severity of illness.A total 65 with S, SS, or SIRS 25 H were included. ELISA was used evaluate extracellular HSP72,...
Abstract Background Mechanical power is a composite variable for energy transmitted to the respiratory system over time that may better capture risk ventilator-induced lung injury than individual ventilator management components. We sought evaluate if mechanical ventilation with high associated fewer ventilator-free days (VFD) in children pediatric acute distress syndrome (PARDS). Methods Retrospective analysis of prospective observational international cohort study. Results There were 306...
Importance Important advances have been made in extracorporeal blood purification therapies (EBPTs) due to new technologies and biomaterials; however, the lack of established guidelines is a factor great variability clinical practice. This aspect accentuated pediatric intensive care given small number patients with diverse diagnoses treated EBPT technical challenges treating children, potentiating risk adverse events. Objective To understand what experienced users think about its relevant...
To analyze the effect of an immune enhancing (IE) diet on infection and metabolic indices in children with severe head injury fed either IE or a regular formula.: Randomized, blinded, controlled study.Pediatric intensive care unit university hospital.A total 40 mechanically ventilated injury.Within 12 hrs pediatric admission, patients were randomized to receive masked formula: formula. Feedings advanced target volume energy intake equal 0.50%, 100%, 125%, 150%, 150% predicted basal rate days...
Abstract Sepsis is a dysregulated host response to infection related devastating outcomes. Recently, interest has been shifted towards apoptotic and antiapoptotic pathobiology. Apoptosis executed through the activation of caspases regulated by number proteins, such as survivin. The survivin caspases’ responses sepsis have not yet elucidated. This multicenter prospective observational study concerning patients with (n = 107) compared traumatic systemic inflammatory syndrome (SIRS) 75) healthy...
Abstract Background Internationally, there is an increasing trend in using Rapid Response Systems (RRS) to stabilize in‐patient deterioration. Despite a growing evidence base, remains limited understanding of the processes place aid early recognition and response deteriorating children hospitals across Europe. Aim/s To describe for deterioration European hospitals. Study Design A cross‐sectional opportunistic multi‐centre study, with paediatric in‐patients, descriptive self‐reported,...
Background: Advances in paediatric critical care have resulted increased survival of critically ill patients, many whom require long-term ventilation as a means life support.