A5035608912- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Clinical Nutrition and Gastroenterology
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Nosocomial Infections in ICU
- Nutrition and Health in Aging
- Electrolyte and hormonal disorders
- Antibiotics Pharmacokinetics and Efficacy
- Infant Nutrition and Health
- Airway Management and Intubation Techniques
- Renal function and acid-base balance
- Intensive Care Unit Cognitive Disorders
- Emergency and Acute Care Studies
- Bacterial Infections and Vaccines
- Vitamin C and Antioxidants Research
- Trauma and Emergency Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Respiratory and Cough-Related Research
- Ear Surgery and Otitis Media
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Streptococcal Infections and Treatments
University of Crete
2016-2025
University Hospital of Heraklion
2016-2025
Clinical Research Consortium
2023
BioCruces Health research Institute
2021
Children's Hospital of Los Angeles
2021
University Medical Center Groningen
2019-2020
University of Groningen
2019-2020
Crete University Press
2019
Great Ormond Street Hospital
2016
University College London
2016
While the relationship between persistent elevations in intracranial pressure (ICP) and poorer outcomes is well established for patients with traumatic brain injury (TBI), there no consensus on how ICP measurements should drive treatment choices, effectiveness of monitoring remains unknown.To evaluate short- mid-term TBI.CREACTIVE was a prospective cohort study that started March 2014 lasted 5 years. More than 8000 TBI were enrolled at 83 intensive care units (ICUs) from 7 countries who...
One of the mechanisms contributing to protection by breast-feeding newborn against enteric diseases is related ability human milk oligosaccharides prevent attachment pathogenic bacteria duodenual epithelium. Indeed, a variety fucosylated oligosaccharides, specific milk, form part innate immune system. In present study, we demonstrate blocking PA-IIL, fucose-binding lectin pathogen Pseudomonas aeruginosa, oligosaccharides. Two epitopes, Lewis and 3-fucosyl-lactose (Lewis x glucose analogue)...
OBJECTIVES: To describe mechanical ventilation management and factors associated with nonadherence to lung-protective principles in pediatric acute respiratory distress syndrome. DESIGN: A planned ancillary study a prospective international observational study. Mechanical (every 6 hr measurements) during syndrome days 0–3 was described compared Pediatric Acute Lung Injury Consensus Conference tidal volume recommendations (< 7 mL/kg children impaired system compliance, < 9 all other...
The purposes of this study are to examine if the human glucocorticoid receptor (hGR) isoform-α mRNA and hGR protein expressions deficient in acute phase sepsis (S) compared systemic inflammatory response syndrome (SIRS) healthy subjects (H) evaluate hGRα alterations associated with cortisol changes they related (1) extracellular intracellular heat shock proteins (HSP) 72 90α; (2) ACTH, prolactin, interleukins (ILs); (3) outcome.Patients consecutively admitted a university hospital intensive...
Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis. This multicenter prospective observational study was designed to ascertain whether an oxidant/antioxidant imbalance independent sepsis discriminator mortality predictor intensive care unit (ICU) patients with (n = 145), compared non-infectious critically ill 112) healthy individuals 89). Serum total oxidative...
Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared healthy children (H); we assessed relation (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic severity of illness.A total 65 with S, SS, or SIRS 25 H were included. ELISA was used evaluate extracellular HSP72,...
Abstract Background Mechanical power is a composite variable for energy transmitted to the respiratory system over time that may better capture risk ventilator-induced lung injury than individual ventilator management components. We sought evaluate if mechanical ventilation with high associated fewer ventilator-free days (VFD) in children pediatric acute distress syndrome (PARDS). Methods Retrospective analysis of prospective observational international cohort study. Results There were 306...
Abstract Sepsis is a dysregulated host response to infection related devastating outcomes. Recently, interest has been shifted towards apoptotic and antiapoptotic pathobiology. Apoptosis executed through the activation of caspases regulated by number proteins, such as survivin. The survivin caspases’ responses sepsis have not yet elucidated. This multicenter prospective observational study concerning patients with (n = 107) compared traumatic systemic inflammatory syndrome (SIRS) 75) healthy...
Traumatic brain injury (TBI) is currently one of the leading causes mortality and disability worldwide. At present, no reliable inflammatory or specific molecular neurobiomarker exists in any standard models proposed for TBI classification prognostication. Therefore, present study was designed to assess value a group mediators evaluating acute TBI, combination with clinical, laboratory radiological indices prognostic clinical scales. In single-centre, prospective observational study, 109...
Abstract Background Internationally, there is an increasing trend in using Rapid Response Systems (RRS) to stabilize in‐patient deterioration. Despite a growing evidence base, remains limited understanding of the processes place aid early recognition and response deteriorating children hospitals across Europe. Aim/s To describe for deterioration European hospitals. Study Design A cross‐sectional opportunistic multi‐centre study, with paediatric in‐patients, descriptive self‐reported,...
Importance Important advances have been made in extracorporeal blood purification therapies (EBPTs) due to new technologies and biomaterials; however, the lack of established guidelines is a factor great variability clinical practice. This aspect accentuated pediatric intensive care given small number patients with diverse diagnoses treated EBPT technical challenges treating children, potentiating risk adverse events. Objective To understand what experienced users think about its relevant...
Identifying and managing medical emergencies presents challenges in healthcare, where familiarity with established algorithms is essential for high-quality care. This study assessed healthcare professionals' understanding of the latest resuscitation guidelines explored their views on lifelong training models. cross-sectional used two multiple-choice questionnaires 50 questions developed by academic emergency critical care consultants based 2021 Consensus Science Treatment Recommendations...
Background: Genetic susceptibility has a major role in the pathogenesis of acute otitis media (AOM). In present study, we investigated variability 5 cytokine genotypes as related to and outcome AOM early infancy. Methods: Single nucleotide polymorphisms IL-6 (–174 G→C), IL-10 (–592 C→A, –819 C→T –1082 G→A), TNF-α (–308 IFN-γ (+874 A→T) TGF-β1 (codon 10 C→T; codon 25 G→C) genes were clinical course 96 infants younger than 9 months with AOM. Results: Compared wild genotypes, (–592, –1082) 10)...
Background: Surveillance is essential to all aspects of management healthcare-associated infections (HAIs) in critically ill children, where data are limited. We conducted an active surveillance study elucidate epidemiology, resistance, antimicrobial treatment practices and outcomes pediatric intensive care unit-acquired HAIs a southern European country. Methods: Four Greek unit encounters (153 patients, 2183 patient-days) during 6-month period participated using the Centre for Disease...
Aim To describe children with pertussis who required intensive care. Methods This is a retrospective analysis of admissions to all (six) national care units in Greece from 2003 2013. Results A total 31 were included, 28 whom younger than 12 months old. Cough was the most prominent symptom, being present 27 (87%) patients, and on admission, only 7 (22.6%) satisfied case definition. Mechanical ventilation initiated 13 (42%) patients. Six patients died because respiratory failure (two) or...
Interventional trials aimed at pediatric acute respiratory distress syndrome prevention require accurate identification of high-risk patients. In this study, we to characterize the frequency and outcomes children meeting "at risk for syndrome" criteria as defined by Pediatric Acute Lung Injury Consensus Conference.Planned substudy prospective multicenter, international Respiratory Distress Syndrome Incidence Epidemiology study conducted during 10 nonconsecutive weeks (May 2016-June...
Background: Both healthcare-associated infections (HAIs) and antimicrobial resistance are associated with an increased length of stay hospital costs, while they have also been linked to high morbidity mortality rates. In 2016 2017, the latest point prevalence survey (PPS) HAIs use in European acute care hospitals highlighted HAI 6.5%, Greece had a higher 10%. The aim this PPS was record all eight public Crete, during COVID-19 pandemic order highlight types practices that need be prioritized...
The climate emergency presents a profound threat to global health, adversely affecting the health and well-being of children who are projected bear substantial disease burden, as well impacting children’s right food, water, healthcare education. sector strives prioritise preventative policies improving individuals across life course. However, current practices significantly contribute greenhouse gas (GHG) emissions waste generation, in which (medical) nutrition plays an important role....